Drug-Drug Interactions with Antiretroviral Drugs in Pregnant Women Living with HIV: Are They Different from Non-Pregnant Individuals?

Autor: Bukkems, VE, Colbers, A, Marzolini, C, Molto, J, Burger, DM

Publikováno v: Clinical Pharmacokinetics
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Background and Objective Although the separate effects of drug-drug interactions and pregnancy on antiretroviral drug pharmacokinetics have been widely studied and described, their combined effect is largely unknown. Physiological changes during preg

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Prediction of Maternal and Fetal Doravirine Exposure by Integrating Physiologically Based Pharmacokinetic Modeling and Human Placenta Perfusion Experiments.

Autor: Bukkems VE; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud university medical center, Nijmegen, the Netherlands. Vera.Bukkems@radboudumc.nl., van Hove H; Department of Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands., Roelofsen D; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud university medical center, Nijmegen, the Netherlands.; Department of Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands., Freriksen JJM; Department of Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands., van Ewijk-Beneken Kolmer EWJ; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud university medical center, Nijmegen, the Netherlands., Burger DM; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud university medical center, Nijmegen, the Netherlands., van Drongelen J; Department of Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, The Netherlands., Svensson EM; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud university medical center, Nijmegen, the Netherlands.; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Greupink R; Department of Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands., Colbers A; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud university medical center, Nijmegen, the Netherlands.

Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2022 Aug; Vol. 61 (8), pp. 1129-1141. Date of Electronic Publication: 2022 May 17.

Effect of Pregnancy and Concomitant Antiretrovirals on the Pharmacokinetics of Tenofovir in Women With HIV Receiving Tenofovir Disoproxil Fumarate-Based Antiretroviral Therapy Versus Women With HBV Receiving Tenofovir Disoproxil Fumarate Monotherapy.

Autor: Bukkems VE; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands., Smolders EJ; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Pharmacy, Isala Hospital, Zwolle, The Netherlands., Jourdain G; French National Research Institute for Sustainable Development (IRD), Marseille, France.; PHPT/IRD UMI 174, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand., Burger DM; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands., Colbers AP; Department of Pharmacy, Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands., Cressey TR; French National Research Institute for Sustainable Development (IRD), Marseille, France.; PHPT/IRD UMI 174, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.; Department of Molecular & Clinical Pharmacology, University of Liverpool, Liverpool, UK.

Publikováno v: Journal of clinical pharmacology [J Clin Pharmacol] 2021 Mar; Vol. 61 (3), pp. 388-393. Date of Electronic Publication: 2020 Sep 22.

Drug-Drug Interactions with Antiretroviral Drugs in Pregnant Women Living with HIV: Are They Different from Non-Pregnant Individuals?

Autor: Bukkems VE; Department of Pharmacy, Radboud University Medical Center and Radboud Institute for Health Sciences (RIHS), Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands., Colbers A; Department of Pharmacy, Radboud University Medical Center and Radboud Institute for Health Sciences (RIHS), Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands. Angela.Colbers@radboudumc.nl., Marzolini C; Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital of Basel and University of Basel, Basel, Switzerland.; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK., Molto J; Fundació Lluita Contra La Sida, Badalona, Spain.; Infectious Diseases Department, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Burger DM; Department of Pharmacy, Radboud University Medical Center and Radboud Institute for Health Sciences (RIHS), Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands.

Publikováno v: Clinical pharmacokinetics [Clin Pharmacokinet] 2020 Oct; Vol. 59 (10), pp. 1217-1236.

Current opinion: antiretrovirals during pregnancy and breastfeeding.

Autor: Nijboer L; Department of Pharmacy, Radboud Institute for Medical Innovations (RIMI), Radboud University Medical Center, Nijmegen, The Netherlands., van der Wekken-Pas L; Department of Pharmacy, Radboud Institute for Medical Innovations (RIMI), Radboud University Medical Center, Nijmegen, The Netherlands., Aebi-Popp K; Department of Infectious Diseases, Bern University Hospital.; Department of Obstetrics and Gynecology, Lindenhofspital, Bern, Switzerland., van Leeuwen E; Department of Obstetrics, Amsterdam Reproduction and Development, Amsterdam University Medical Center, Amsterdam, The Netherlands., Colbers A; Department of Pharmacy, Radboud Institute for Medical Innovations (RIMI), Radboud University Medical Center, Nijmegen, The Netherlands.

Publikováno v: Current opinion in HIV and AIDS [Curr Opin HIV AIDS] 2024 Nov 01; Vol. 19 (6), pp. 305-315. Date of Electronic Publication: 2024 Sep 20.