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Akademický článek

Commonly used anesthetics modify alcohol and (-)-trans-delta9-tetrahydrocannabinol in vivo effects on rat cerebral arterioles

Autor: Steven Mysiewicz, Brianne Hibl, Alex Dopico, Anna Bukiya

Publikováno v: BMC Anesthesiology, Vol 23, Iss 1, Pp 1-15 (2023)

Abstract Background Ethyl alcohol and cannabis are widely used recreational substances with distinct effects on the brain. These drugs increase accidental injuries requiring treatment under anesthesia. Moreover, alcohol and cannabis are often used in

Externí odkaz: https://doaj.org/article/67f947eaeeda40dcba5ccf119bc5079d

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Akademický článek

Progesterone activation of β1-containing BK channels involves two binding sites

Autor: Kelsey C. North, Andrew A. Shaw, Anna N. Bukiya, Alex M. Dopico

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Progesterone (≥1 µM) is used in recovery of cerebral ischemia, an effect likely contributed to by cerebrovascular dilation. The targets of this progesterone action are unknown. We report that micromolar (µM) progesterone activates mouse

Externí odkaz: https://doaj.org/article/0cdd746863a54d70aef7f6c8c45441d0

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Akademický článek

Alcohol and pregnenolone interaction on cerebral arteries through targeting of vascular smooth muscle Ca2+- and voltage-gated K+ channels of big conductance

Autor: Kelsey C. North, Andrew A. Shaw, Luiz Moreira, Anna N. Bukiya, Alex M. Dopico

Publikováno v: Advances in Drug and Alcohol Research, Vol 3 (2023)

Despite the significant number of people who may be taking pregnenolone supplements while drinking alcohol (ethanol), the widely documented cerebrovascular actions of pregnenolone and ethanol, and the critical dependence of cerebrovascular function o

Externí odkaz: https://doaj.org/article/8d09a388bacd4d38acebd4ee393c978c

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