Collagen for brain repair: therapeutic perspectives

Autor: Buket Ucar, Christian Humpel

Publikováno v: Neural Regeneration Research, Vol 13, Iss 4, Pp 595-598 (2018)

Biomaterials have increasingly become a focus of research on neuroprotection and neuroregeneration. Collagen, in terms of brain repair, presents many advantages such as being remarkably biocompatible, biodegradable, versatile and non-toxic. Collagen

Externí odkaz: https://doaj.org/article/c3229051484b472ab4a2ebffd1ab607c

Biomaterial based strategies to reconstruct the nigrostriatal pathway in organotypic slice co-cultures

Autor: Abhay Pandit, Joëlle Bizeau, Christian Humpel, Katherine R. Long, Carsten Werner, Ben Newland, Buket Ucar, Dimitri Eigel, Janko Kajtez, Bettina M. Foidl, Jenny Emnéus, Mihai Lomora

Publikováno v: Ucar, B, Kajtez, J, Foidl, B M, Eigel, D, Werner, C, Long, K R, Emnéus, J, Bizeau, J, Lomora, M, Pandit, A, Newland, B & Humpel, C 2021, ' Biomaterial based strategies to reconstruct the nigrostriatal pathway in organotypic slice co-cultures ', Acta Biomaterialia, vol. 121, pp. 250-262 . https://doi.org/10.1016/j.actbio.2020.11.035

Protection or repair of the nigrostriatal pathway represents a principal disease-modifying therapeutic strategy for Parkinson's disease (PD). Glial cell line-derived neurotrophic factor (GDNF) holds great therapeutic potential for PD, but its efficac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbe57c837e02262d93fb887f43630fc
https://doi.org/10.1016/j.actbio.2020.11.035

Collagen hydrogels loaded with fibroblast growth factor-2 as a bridge to repair brain vessels in organotypic brain slices

Autor: Christian Humpel, Buket Ucar, Sedef Yusufogullari

Publikováno v: Experimental Brain Research

Vessel damage is a general pathological process in many neurodegenerative disorders, as well as spinal cord injury, stroke, or trauma. Biomaterials can present novel tools to repair and regenerate damaged vessels. The aim of the present study is to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db58dab3840fc4fea3e62379fd77722
https://doi.org/10.1007/s00221-020-05907-7

Nerve growth factor released from collagen scaffolds protects axotomized cholinergic neurons of the basal nucleus of Meynert in organotypic brain slices

Autor: Alina Schwarz, Abhay Pandit, Bettina M. Foidl, Christian Humpel, Ana Lúcia Rebelo, Buket Ucar

Publikováno v: Journal of Neuroscience Methods

Background Alzheimeŕs disease is accompanied by cell death of cholinergic neurons, resulting in cognitive impairment and memory loss. Nerve growth factor (NGF) is the most potent protein to support survival of cholinergic neurons. New Method Organot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2e9351b4dcc91b4ebf2ded988f6651