Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer.

Autor: Kayhanian H; UCL Cancer Institute, University College London, London, UK., Cross W; UCL Cancer Institute, University College London, London, UK.; Cancer Mechanisms and Biomarker Discovery Group, School of Life Sciences, University of Westminster, London, UK., van der Horst SEM; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Barmpoutis P; UCL Cancer Institute, University College London, London, UK.; UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK., Lakatos E; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden., Caravagna G; Department of Mathematics, Informatics and Geosciences, University of Trieste, Trieste, Italy., Zapata L; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Van Hoeck A; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Middelkamp S; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Litchfield K; UCL Cancer Institute, University College London, London, UK., Steele C; UCL Cancer Institute, University College London, London, UK., Waddingham W; UCL Cancer Institute, University College London, London, UK., Patel D; UCL Cancer Institute, University College London, London, UK., Milite S; Department of Mathematics, Informatics and Geosciences, University of Trieste, Trieste, Italy., Jin C; UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK., Baker AM; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Alexander DC; UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK., Khan K; Department of Oncology, UCL Cancer Institute, University College London, London, UK., Hochhauser D; UCL Cancer Institute, University College London, London, UK.; Department of Oncology, UCL Cancer Institute, University College London, London, UK., Novelli M; UCL Cancer Institute, University College London, London, UK.; Department of Pathology, University College London Hospital, London, UK., Werner B; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., van Boxtel R; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Hageman JH; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Buissant des Amorie JR; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Linares J; HSL-AD, London, UK., Ligtenberg MJL; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Nagtegaal ID; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Laclé MM; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Moons LMG; Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands., Brosens LAA; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Pillay N; UCL Cancer Institute, University College London, London, UK., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Graham TA; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Rodriguez-Justo M; UCL Cancer Institute, University College London, London, UK.; Department of Pathology, University College London Hospital, London, UK., Shiu KK; UCL Cancer Institute, University College London, London, UK.; Department of Oncology, UCL Cancer Institute, University College London, London, UK., Snippert HJG; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. h.j.g.snippert@umcutrecht.nl., Jansen M; UCL Cancer Institute, University College London, London, UK. m.jansen@ucl.ac.uk.; Department of Pathology, University College London Hospital, London, UK. m.jansen@ucl.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2024 Jul; Vol. 56 (7), pp. 1420-1433. Date of Electronic Publication: 2024 Jul 03.

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling.

Autor: Ponsioen B; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Post JB; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Buissant des Amorie JR; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Laskaris D; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., van Ineveld RL; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Kersten S; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Bertotti A; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy., Sassi F; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy., Sipieter F; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; Institut Jacques Monod, CNRS UMR 7592, Université Paris Diderot, Paris, France., Cappe B; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium., Mertens S; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Verlaan-Klink I; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Boj SF; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands., Vries RGJ; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands., Rehmann H; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Vandenabeele P; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium., Riquet FB; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; University of Lille, Villeneuve d'Ascq, France., Trusolino L; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy., Bos JL; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Snippert HJG; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl.; Oncode Institute, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl.

Publikováno v: Nature cell biology [Nat Cell Biol] 2021 Apr; Vol. 23 (4), pp. 377-390. Date of Electronic Publication: 2021 Apr 01.