Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Buhm Han"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background Meta-analysis is a statistical method that combines the results of multiple studies to increase statistical power. When multiple studies participating in a meta-analysis utilize the same public dataset as controls, the summary sta
Externí odkaz:
https://doaj.org/article/4750f38444de47ecadc17e717fda1690
Publikováno v:
HGG Advances, Vol 4, Iss 4, Pp 100223- (2023)
Summary: Accurate imputation of tissue-specific gene expression can be a powerful tool for understanding the biological mechanisms underlying human complex traits. Existing imputation methods can be grouped into two categories according to the types
Externí odkaz:
https://doaj.org/article/e34342f724d1456b971fb801483ef01d
Autor:
Hanbin Lee, Buhm Han
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-6 (2022)
Abstract Most genomic cohorts are retrospective where the exposures and outcomes are predetermined prior to sample collection. Therefore, a spurious association between an exposure and an outcome can arise if both variables affect study participation
Externí odkaz:
https://doaj.org/article/e20f5c014e6c456aa8cbafd1cfc2787f
Autor:
Hyung-Don Kim, Sun Young Kim, Jihun Kim, Jeong Eun Kim, Yong Sang Hong, Buhm Han, Eunyoung Tak, Yeon-Mi Ryu, Sang-Yeob Kim, Tae Won Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract We aimed to investigate the dynamic changes of gene expression profiles and immune microenvironment linked to resistance to cetuximab-based treatments in patients with metastatic colorectal cancer (mCRC). A total of 106 patients with RAS-wil
Externí odkaz:
https://doaj.org/article/7a3caa9bb1ae488ab126362d5cd4a784
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Although B cells and T cells are integral players of the adaptive immune system and act in co-dependent ways to orchestrate immune responses, existing methods to study the immune repertoire have largely focused on separate analyses of B cell receptor
Externí odkaz:
https://doaj.org/article/7c73bddd165d42cd8f296b1c92825171
Autor:
Seungho Cook, Wanson Choi, Hyunjoon Lim, Yang Luo, Kunhee Kim, Xiaoming Jia, Soumya Raychaudhuri, Buhm Han
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Human leukocyte antigen (HLA) genes influence many immune phenotypes, however methods to impute HLA type have been limited in accuracy. Here, the authors present an HLA imputation method, CookHLA, which uses locally embedded prediction markers to ada
Externí odkaz:
https://doaj.org/article/004f4796d69f4d56bd2fd5ed3d50b1b1
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009596 (2021)
The rapid decrease in sequencing cost has enabled genetic studies to discover rare variants associated with complex diseases and traits. Once this association is identified, the next step is to understand the genetic mechanism of rare variants on how
Externí odkaz:
https://doaj.org/article/1ecd002ea1c34e409a4edb230dba15e1
Autor:
Dong Ha Kim, HyeongRyul Kim, Yun Jung Choi, Seon Ye Kim, Jung-Eun Lee, Ki Jung Sung, Young Hoon Sung, Chan-Gi Pack, Min-kyo Jung, Buhm Han, Kunhee Kim, Woo Sung Kim, Soo Jeong Nam, Chang-Min Choi, Miyong Yun, Jae Cheol Lee, Jin Kyung Rho
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 8, Pp 1-13 (2019)
Lung cancer: Immune suppressant protein promotes tumor growth An immune suppressant protein expressed by non-small cell lung cancer cells (NSCLC) to facilitate tumor growth could be a valuable therapeutic target. NSCLC is often diagnosed at advanced
Externí odkaz:
https://doaj.org/article/6cca9d9f469c4be3ba044ab1c3244399
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-5 (2019)
Abstract Genomic global positioning system (GPS) applies the multilateration technique commonly used in the GPS to genomic data. In the framework we present here, investigators calculate genetic distances from their samples to reference samples, whic
Externí odkaz:
https://doaj.org/article/af8914e1720943659b1326e62d039f08
Publikováno v:
The Korean Journal of Internal Medicine, Vol 36, Iss Suppl 1, Pp S142-S150 (2021)
Background/Aims Lung function is an objective indicator of diagnosis and prognosis of respiratory diseases. Many common genetic variants have been associated with lung function in multiple ethnic populations. We looked for coding variants associated
Externí odkaz:
https://doaj.org/article/0a8687e87a95405db83d76375bb1d4e6