The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates.

Autor: Buhigas, Claudia¹ (AUTHOR), Warren, Anne Y.² (AUTHOR), Leung, Wing-Kit³ (AUTHOR), Whitaker, Hayley C.^3,4 (AUTHOR), Luxton, Hayley J.^3,4 (AUTHOR), Hawkins, Steve³ (AUTHOR), Kay, Jonathan^3,4 (AUTHOR), Butler, Adam⁵ (AUTHOR), Xu, Yaobo⁵ (AUTHOR), Woodcock, Dan J.⁶ (AUTHOR), Merson, Sue⁷ (AUTHOR), Frame, Fiona M.⁸ (AUTHOR), Sahli, Atef⁶ (AUTHOR), Abascal, Federico⁵ (AUTHOR), CRUK-ICGC Prostate Cancer Group (AUTHOR), Gihawi, Abraham (AUTHOR), Lambert, Adam (AUTHOR), Thompson, Alan (AUTHOR), Futreal, Andrew (AUTHOR), Menzies, Andrew (AUTHOR)

Publikováno v: Molecular Cancer. 9/22/2022, Vol. 21 Issue 1, p1-16. 16p.

Single-cell multi-omic analysis profiles defective genome activation and epigenetic reprogramming associated with human pre-implantation embryo arrest

Autor: Hernandez Mora, Jose Ramon, Buhigas, Claudia, Clark, Stephen, Gallego Bonilla, Raquel del, Daskeviciute, Dagne, Monteagudo Sánchez, Ana, Poo Llanillo, Maria Eugenia, Medrano, Jose Vicente, Simón, Carlos, Meseguer, Marcos, Kelsey, Gavin, Monk, David

During pre-implantation stages of mammalian development, maternally stored material promotes both the erasure of the sperm and oocyte epigenetic profiles and is responsible for concomitant genome activation. Here, we have utilized single-cell methylo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc1a0fa0a74a6292fa2f8f69208eea5
https://ueaeprints.uea.ac.uk/id/eprint/91262/

Additional file 2 of The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

Autor: Buhigas, Claudia, Warren, Anne Y., Leung, Wing-Kit, Whitaker, Hayley C., Luxton, Hayley J., Hawkins, Steve, Kay, Jonathan, Butler, Adam, Xu, Yaobo, Woodcock, Dan J., Merson, Sue, Frame, Fiona M., Sahli, Atef, Abascal, Federico, Martincorena, Iñigo, Bova, G. Steven, Foster, Christopher S., Campbell, Peter, Maitland, Norman J., Neal, David E., Massie, Charlie E., Lynch, Andy G., Eeles, Rosalind A., Cooper, Colin S., Wedge, David C., Brewer, Daniel S.

Additional file 2: Supplementary Figure 1. Age vs number of SNVs detected for normal tissue from Prostate cancer patients and non-prostate cancer donors. For the non-cancer donors, the number of SNVs detected is remarkably consistent (range: 104 to 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6b26aa8979649c9f5c4d759e9555bb

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Single-cell multi-omic analysis profiles defective genome activation and epigenetic reprogramming associated with human pre-implantation embryo arrest.

Autor: Hernandez Mora JR; Bellvitge Institute for Biomedical Research, 08908 Barcelona, Spain., Buhigas C; Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7JT, UK., Clark S; The Babraham Institute, Babraham, Cambridge CB22 3AT, UK., Del Gallego Bonilla R; IVI-RMA Global and Health Research Institute la Fe, 46026 Valencia, Spain., Daskeviciute D; Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7JT, UK., Monteagudo-Sánchez A; Bellvitge Institute for Biomedical Research, 08908 Barcelona, Spain., Poo-Llanillo ME; Igenomix SL, 46980 Valencia, Spain., Medrano JV; IVI-RMA Global and Health Research Institute la Fe, 46026 Valencia, Spain; Department of Obstetrics and Gynecology, Valencia University and INCLIVA, 46010 Valencia, Spain., Simón C; Department of Obstetrics and Gynecology, Valencia University and INCLIVA, 46010 Valencia, Spain; Department of Obstetrics and Gynecology, BIDMC, Harvard University, Boston, MA 02215, USA., Meseguer M; IVI-RMA Global and Health Research Institute la Fe, 46026 Valencia, Spain., Kelsey G; The Babraham Institute, Babraham, Cambridge CB22 3AT, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EL, UK; Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories, Cambridge CB2 0QQ, UK., Monk D; Bellvitge Institute for Biomedical Research, 08908 Barcelona, Spain; Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7JT, UK. Electronic address: d.monk@uea.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2023 Feb 28; Vol. 42 (2), pp. 112100. Date of Electronic Publication: 2023 Feb 09.