Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Buffy S, Ellsworth"'
Autor:
Julian Martinez-Mayer, Michelle L. Brinkmeier, Sean P. O’Connell, Arnold Ukagwu, Marcelo A. Marti, Mirta Miras, Maria V. Forclaz, Maria G. Benzrihen, Leonard Y. M. Cheung, Sally A. Camper, Buffy S. Ellsworth, Lori T. Raetzman, Maria I. Pérez-Millán, Shannon W. Davis
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Congenital hypopituitarism (CH) and its associated syndromes, septo-optic dysplasia (SOD) and holoprosencephaly (HPE), are midline defects that cause significant morbidity for affected people. Variants in 67 genes are associated w
Externí odkaz:
https://doaj.org/article/0bbc158ef495443f94e7c8846687f0bb
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
Gonadotrope cells of the anterior pituitary are characterized by their ability to mount a cyclical pattern of gonadotropin secretion to regulate gonadal function and fertility. Recent in vitro and in vivo evidence suggests that gonadotropes exhibit d
Externí odkaz:
https://doaj.org/article/6f39f7aacef04ca689e915897f437192
Publikováno v:
Endocrinology
Understanding the molecular mechanisms underlying pituitary organogenesis and function is essential for improving therapeutics and molecular diagnoses for hypopituitarism. We previously found that deletion of the forkhead factor, Foxo1, in the pituit
Autor:
Michael J Calderon, Adam G Ploegman, Brock Bailey, Deborah O Jung, Amy M Navratil, Buffy S Ellsworth
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128942 (2015)
FOXM1, a member of the forkhead box transcription factor family, plays a key role in cell cycling progression by regulating the expression of critical G1/S and G2/M phase transition genes. In vivo studies reveal that Foxm1 null mice have a 91% lethal
Externí odkaz:
https://doaj.org/article/78ba624a8ef942638fed184002948526
Publikováno v:
Journal of the Endocrine Society
Growth hormone (GH) is a well-known metabolic factor secreted by pituitary somatotropes. Transcription factors such as POU1F1 and NEUROD4 promote somatotrope differentiation, maturation, and function. The forkhead transcription factor, FOXO1, is nece
Autor:
Jason H Gumbel, Elizabeth M Patterson, Sarah A Owusu, Brock E Kabat, Deborah O Jung, Jasmine Simmons, Torin Hopkins, Buffy S Ellsworth
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52156 (2012)
The pituitary gland regulates numerous physiological functions including growth, reproduction, temperature and metabolic homeostasis, lactation, and response to stress. Pituitary organogenesis is dependent on signaling factors that are produced in an
Externí odkaz:
https://doaj.org/article/a87e55049ddc461ca4d89bed469c7cc1
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52136 (2012)
Congenital pituitary hormone deficiencies have been reported in approximately one in 4,000 live births, however studies reporting mutations in some widely studied transcription factors account for only a fraction of congenital hormone deficiencies in
Externí odkaz:
https://doaj.org/article/62bcbd516a034ddfa38f882f316fab5a
Autor:
Alexandre Z. Daly, Stacey McGee, Buffy S. Ellsworth, Akima S. George, Michelle L. Brinkmeier, Leonard Y.M. Cheung, Sally A. Camper
Publikováno v:
Endocrinology. 159:3910-3924
Transcription factors and signaling pathways that regulate stem cells and specialized hormone-producing cells in the pituitary gland have been the subject of intense study and have yielded a mechanistic understanding of pituitary organogenesis and di
Publikováno v:
Trends in Endocrinology & Metabolism. 29:510-523
Pituitary somatotropes secrete growth hormone (GH), which is essential for normal growth and metabolism. Somatotrope defects result in GH deficiency (GHD), leading to short stature in childhood and increased cardiovascular morbidity and mortality in
Publikováno v:
Journal of the Endocrine Society
Pituitary gland function is regulated by the activity of various transcription factors which control cell fate decisions leading to cellular differentiation and hormone production. FOXO1 is necessary for the proper timing of somatotrope differentiati