A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

Autor: Diane Cote, Jeri Sieren, Alex Rajput, James W. Tetrud, Paul J. Tuite, Christopher T. Ingvoldstad, Cheryl Waters, Shari Niswonger, Roger Kurlan, David D. Song, Jennifer Young, Samuel Markind, Alicia Palao, Munira Sultana, Christine Hunter, Karen Williams, Sandra K. Kostyk, John G. Nutt, Andrew Feigin, Dragos Mihaila, Karen Blindauer, Abraham Lieberman, Annette Robinson, Adrienna Winters, Michelle Cines, Mattson Ogg, Robert A. Hauser, Ira Shoulson, Julia Spears, Jorge L. Juncos, William G. Ondo, David Simon, Mark Stacy, Stacy Merritt, Barbara Shannon, Un Jung Kang, Katie Kompoliti, Cheryl Deeley, Joanne Field, Arthur Watts, Buff Farrow, Karen Helles, Katharine Smith, Karen Thomas, Rajan Prakash, Joel S. Perlmutter, Rajeev Kumar, Mandar Jog, Pamela King, Neal Hermanowicz, Stephen G. Reich, Mark Chilton, Lawrence Severt, Vanessa K. Hinson, Kapil D. Sethi, Mark F. Lew, Pinky Agarwal, Clifford M Shults, Natividad Stover, Richard H. Haas, Jayaraman Rao, Thomas Mayer, Thyagarajan Subramanian, Althea Silver, Richard M. Zweig, Lin Zhang, Hubert H. Fernandez, Linda Cole, Charles H. Adler, Jean Rivest, Marye Kellermann, Marlene Lind, Stephanie Wilson, Jennifer Conway, Ray L. Watts, Monica Beland, Joseph H. Friedman, Michael S. Okun, Maureen Cook, Stephen Grill, Cindy Zadikoff, Irene Litvan, Donna Stuppy Ford, Karen Frei, L Pepper Lumina, David Grimes, Sofya Glazman, Edward Drasby, Wendy R. Galpern, Susan Rolandelli, Sharon Evans, Bernard Ravina, Robert W. Hamill, Jo Bergholte, Andrew Siderowf, W.R. Wayne Martin, Rajesh Pahwa, Sanja Obradov, April Langhammer, Lorelei Derwent, Barbara Sommerfeld, M. Flint Beal, Alok Sahay, Anita Blenke, Liza Reys, Melisa Pelikan, Amy Duffy, Holly A. Shill, Eric Molho, Ivan Bodis-Wollner, Candace Cotto, Marilyn Cowper, Marian L. Evatt, Ani Arkun, Johanna M Hartlein, Nancy Zappala, Clara Schindler Propsom, Matthew Brodsky, Colette Lynn Hilliard, Stephanie Lessig, Stephanie Guthrie, Joanne Wojcieszek, Deborah Fontaine, Irene H. Richard, Zoltan Mari, Kathy Davis, Carlos Singer, Samuel A. Ellias, Lawrence Elmer, Julie So, Louisette Bond, Janis M. Miyasaki, Camille Swartz, Ranjit Ranawaya, Brian Griebner, Ramon L. Rodriguez, Ronald F. Pfeiffer, Becky Dunlop, David Oakes, Michel Panisset, Tiffini Voss, Joohi Jimenez-Shahed, Karyn Boyar, Cathi-Ann Thomas, Victoria Snively, Claire Henchcliffe, Margaret C. Lannon, Maureen Gartner, Cherissa Sia, Maureen A. Leehey, Joan Young, Anwar Ahmed, David S. Russell, Melissa J. Nirenberg, Emmanuelle Pourcher, James T. Boyd, Lauren Kraics, Ted M. Dawson, Ergun Y. Uc, Shan Gao, Angel Figueroa

Publikováno v: JAMA Neurology. 71:543

Importance Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbaa699332e1164a6e43ffbb175898c5
https://doi.org/10.1001/jamaneurol.2014.131