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Role of CD3gamma and CD3delta cytoplasmic domains in cytolytic T lymphocyte functions and TCR/CD3 down-modulation

Autor: Luton F, Buferne M, Legendre V, Chauvet E, Boyer C, Anne-Marie Schmitt-Verhulst

Publikováno v: Europe PubMed Central

TCR engagement leads to down-modulation of TCR/CD3 complexes from the T cell surface. The importance of this effect in T cell physiology is unknown. Here, we characterized a CTL clone deficient in TCR/CD3 surface expression that had lost both CD3delt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86bd9ed7811507b318d97d9d31bad1c
https://doi.org/10.4049/jimmunol.158.9.4162

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Developmental control of T-cell receptor internalization

Autor: Luton F, Buferne M, Anne-Marie Schmitt-Verhulst, Boyer C

Publikováno v: Europe PubMed Central

Since TCR/CD3 modulation may be involved in induction of T cell tolerance to self antigens, we compared ligand-induced TCR/CD3 internalization by a CTL clone and by immature thymocytes and mature T cells from mice bearing the same TCR alpha beta as t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::638811a2ca182c18345265787aa77d27
https://pubmed.ncbi.nlm.nih.gov/7863544

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