Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Budralazine"'
Autor:
Masato Eto, Kazuaki Shimamoto, Seturou Ibayashi, Mikihiro Takasaki, Katuhiko Kohara, Shigeto Morimoto, Kunio Hiwada, T. Nakamura, Atushi Masuda, Isao Abe, Yoshitoki Takagawa, Yutaka Kiyohara, Hiroshi Mikami, Hiroaki Matsuoka, Toshio Ogihara, Masayuki Matsumoto, Satoshi Takizawa, Masatoshi Fujishima, Toshihiko Ishimitsu, Takeshi Nakahashi, Yasuyoshi Onchi, Junnichi Munehira
Publikováno v:
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 36:342-352
Although calcium-channel blockers and angiotensin-I-converting enzyme inhibitors are often used for treatment of hypertension in the elderly in Japan compared to those in the United States and in European countries, there have been few investigations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c998263f38f037851c8a51c12895d6
https://doi.org/10.3143/geriatrics.36.342
https://doi.org/10.3143/geriatrics.36.342
Publikováno v:
Clinical and Experimental Hypertension. Part A: Theory and Practice. 13:1107-1114
The present study was undertaken to elucidate the anti-tachycardic effect of a direct-acting vasodilator, budralazine, using an electrophysiological technique. Normotensive male Wistar rats were used. Rats were anesthetized intraperitoneally with ure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165b7247fa140e7c07280c43dc438452
https://doi.org/10.3109/10641969109042116
https://doi.org/10.3109/10641969109042116
Publikováno v:
Japanese Journal of Pharmacology. 53:502-505
The effects of antihypertensive drugs on ischemic cerebral damage were investigated using the bilateral carotid artery occlusion (BCAO) model in SHR. Oral budralazine and nifedipine, at doses that increased cerebral blood flow (CBF) in SHR in our pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888eb7f1426903305b18e001f981a291
https://doi.org/10.1254/jjp.53.502
https://doi.org/10.1254/jjp.53.502
Autor:
Tsunehiro Kawamura, Teruo Kitani, Mitsuro Watada, Yasushi Okajima, Kenhiro Rin, Shunyo Kanayama, Yoshiharu Maeda, Masao Nakagawa, Kichiro Osamura, Hamao Ijichi
Publikováno v:
Blood & Vessel. 14:65-69
Vasodilator drugs have often been applied clinically to the patients with ischemic heart disease or hypertension, and their antiplatelet activity have been evaluated recently. This paper reports the effects of Hydralazine, Budralazine, Verapamil and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5910b8c5cdf9b9605a4320614bf83b3
https://doi.org/10.2491/jjsth1970.14.65
https://doi.org/10.2491/jjsth1970.14.65
Publikováno v:
Xenobiotica. 9:227-236
1. [14C]Budralazine (I) administered orally to normotensive and spontaneously hypertensive rats showed no significant difference in metabolic fate between the two groups. 2. Peak plasma levels of 14C were 3.6 microgram equiv. of I per ml in both norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fbdb34f17a355de816d0002c5f2e11
https://doi.org/10.3109/00498257909038725
https://doi.org/10.3109/00498257909038725
Publikováno v:
Folia Pharmacologica Japonica. 87:301-311
Budralazine was evaluated for its effects on glucose and lipid metabolism in diabetic SHR. SHR treated with 10% sucrose solution as drinking water for 3 months exhibited an impaired glucose tolerance with higher serum insulin levels and a reduction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade4c70fc36c5d39b36f11b5b441b4c8
https://doi.org/10.1254/fpj.87.301
https://doi.org/10.1254/fpj.87.301
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 421:367-371
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc29e5bf912f25a565e5586af601f9d1
https://doi.org/10.1016/0378-4347(87)80418-8
https://doi.org/10.1016/0378-4347(87)80418-8
Publikováno v:
Toxicology and Applied Pharmacology. 44:431-439
Budralazine, 1-[2-(1,3-dimethyl-2-butylidene)-hydrazino]-phthalazine, an antihypertensive drug, has been evaluated toxicologically in mice and rats. The acute oral toxicity of budralazine was 10 and 2 times lower in mice and rats, respectively, than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31548e88f55b0d5fcafd06d987c85a77
https://doi.org/10.1016/0041-008x(78)90251-x
https://doi.org/10.1016/0041-008x(78)90251-x
Autor:
Naoko Mikuriya, Keiichi Tanaka, Hisashi Miyazaki, Masahisa Hashimoto, Akira Kagemoto, Yutaka Sekine, Hideki Amejima, Toshihiko Fujii, Toshiyuki Negoro
Publikováno v:
Drug Metabolism and Pharmacokinetics. 2:613-624
For elucidation of common characteristics in disposition of hydralazine vasodilators, distribution of [14C]hydralazine and [14C]budralazine was studied in normal rats at the time points of their maximal tissue levels and at 24 hr after single and 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f3185318030b7442dac8d7ea04ba175
https://doi.org/10.2133/dmpk.2.613
https://doi.org/10.2133/dmpk.2.613
Publikováno v:
Drug Metabolism and Pharmacokinetics. 2:487-496
Three new metabolites of budralazine, an antihypertensive drug, were isolated from urine, bile and liver-perfusion effluent of rats, and their structures were identified by direct comparison with authentic samples. A major urinary metabolite was iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86153b4d94bcafd81f115f527d09d1d6
https://doi.org/10.2133/dmpk.2.487
https://doi.org/10.2133/dmpk.2.487