Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Buddy Ullman"'
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152715 (2016)
Trypanosoma cruzi is incapable of synthesizing putrescine or cadaverine de novo, and, therefore, salvage of polyamines from the host milieu is an obligatory nutritional function for the parasite. A high-affinity diamine transporter (TcPOT1) from T. c
Externí odkaz:
https://doaj.org/article/662f53e96bb548e490c9c2e6aca2b154
Publikováno v:
Molecular and Biochemical Parasitology. 208:74-83
Purine acquisition is an essential nutritional process for Leishmania. Although purine salvage into adenylate nucleotides has been investigated in detail, little attention has been focused on the guanylate branch of the purine pathway. To characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2342a9922bc57b1d43424cd3f8e7442
https://doi.org/10.1016/j.molbiopara.2016.06.008
https://doi.org/10.1016/j.molbiopara.2016.06.008
Autor:
Jessica L. Martin, Nicola S. Carter, Audrey L. Fulwiler, Buddy Ullman, Maria B. Cassera, Dennis R. Koop, Jan M. Boitz, Phillip A. Yates
Publikováno v:
Molecular Microbiology. 101:299-313
Purine salvage by Leishmania is an obligatory nutritional process that impacts both cell viability and growth. Previously, we have demonstrated that the removal of purines in culture provokes significant metabolic changes that enable Leishmania to su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4aadb00baf7f7188b5f9aed0d2bfdf4d
https://doi.org/10.1111/mmi.13390
https://doi.org/10.1111/mmi.13390
Autor:
Sigrid C. Roberts, Buddy Ullman
Publikováno v:
Current pharmaceutical design. 23(23)
There is an urgent need for the identification and validation of new therapeutic targets in protozoan parasites because currently available drugs are limited in number and usefulness, and no vaccines are available. The discovery that alpha-difluorome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5ea200541de68532a8a62b672f57d7
https://pubmed.ncbi.nlm.nih.gov/28571553
https://pubmed.ncbi.nlm.nih.gov/28571553
Autor:
Buddy Ullman, Phillip A. Yates, Isaac P. Forquer, Zachary N. Wilson, Johannes Elferich, Ujwal Shinde, Radika Soysa, Michael K. Riscoe
Publikováno v:
Journal of Biological Chemistry. 288:29954-29964
The pathogenic protozoan parasite Leishmania donovani is capable of both de novo pyrimidine biosynthesis and salvage of pyrimidines from the host milieu. Genetic analysis has authenticated L. donovani uracil phosphoribosyltransferase (LdUPRT), an enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674cfd976686c4182d722f223e96b7de
https://doi.org/10.1074/jbc.m113.478826
https://doi.org/10.1074/jbc.m113.478826
Autor:
Buddy Ullman, Jan M. Boitz
Publikováno v:
Molecular and Biochemical Parasitology. 190:51-55
6-aminopurine metabolism in Leishmania is unique among trypanosomatid pathogens since this genus expresses two distinct routes for adenine salvage: adenine phosphoribosyltransferase (APRT) and adenine deaminase (AAH). To evaluate the relative contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061ed67700cf71d40c2f12344e7bf161
https://doi.org/10.1016/j.molbiopara.2013.06.005
https://doi.org/10.1016/j.molbiopara.2013.06.005
Publikováno v:
Journal of Biological Chemistry. 288:8977-8990
Leishmania are auxotrophic for purines, and consequently purine acquisition from the host is a requisite nutritional function for the parasite. Both adenylosuccinate synthetase (ADSS) and adenylosuccinate lyase (ASL) have been identified as vital com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5ec0d84d52c05faaa7f79929854d84
https://doi.org/10.1074/jbc.m112.431486
https://doi.org/10.1074/jbc.m112.431486
Publikováno v:
Biochemical Journal, 452, 423-32
Biochemical Journal, 452, 3, pp. 423-32
Biochemical Journal, 452, 3, pp. 423-32
Contains fulltext : 117693.pdf (Publisher’s version ) (Closed access) The TcPOT1.1 gene from Trypanosoma cruzi encodes a high affinity putrescine-cadaverine transporter belonging to the APC (amino acid/polyamine/organocation) transporter superfamil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046303463e1def2e4c8019124f7bea3e
https://hdl.handle.net/2066/117693
https://hdl.handle.net/2066/117693
Autor:
Diana Ortiz, Isaac P. Forquer, Audrey L. Fulwiler, Aaron Nilsen, Radika Soysa, Tamsen Polley, Buddy Ullman, Scott M. Landfear, Carolyn Elya, Michael K. Riscoe, Jan M. Boitz
Endochin-like quinolones (ELQs) are potent and specific inhibitors of cytochrome bc 1 from Plasmodium falciparum and Toxoplasma gondii and show promise for novel antiparasitic drug development. To determine whether the mitochondrial electron transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c2d14f14cd4d4e95a1637f359d23a6
https://europepmc.org/articles/PMC4958202/
https://europepmc.org/articles/PMC4958202/
Autor:
Buddy Ullman, Tamara Olenyik, Sigrid C. Roberts, Kristie Dearman, Yuexin Li, Caslin Gilroy, Dustin K Paradis, Phillip A. Yates, Michael K. Riscoe, Jan M. Boitz, Jasmine Perdeh, Madison Davis
Publikováno v:
Infection and Immunity
Studies of Leishmania donovani have shown that both ornithine decarboxylase and spermidine synthase, two enzymes of the polyamine biosynthetic pathway, are critical for promastigote proliferation and required for maximum infection in mice. However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcd603ab3019aa4588e518756750cbc
https://pubmed.ncbi.nlm.nih.gov/27795357
https://pubmed.ncbi.nlm.nih.gov/27795357