Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Buddy Pouw"'
Publikováno v:
Pharmacology Biochemistry and Behavior. 86:86-91
Earlier studies have demonstrated that antagonism of sigma1 receptors attenuates the convulsive, lethal, locomotor stimulatory and rewarding actions of cocaine in mice. In contrast, the contribution of sigma2 receptors is unclear because experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63076741864209b6ec5426fe3d1b2457
https://doi.org/10.1016/j.pbb.2006.12.011
https://doi.org/10.1016/j.pbb.2006.12.011
Publikováno v:
Neuropharmacology. 49:638-645
Methamphetamine interacts with sigma (sigma) receptors, suggesting that the drug produces some of its physiological and behavioral effects through these sites. Therefore, in the present report, receptor binding and pharmacological studies were perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7894d54f506caa603fbfef09788019e1
https://doi.org/10.1016/j.neuropharm.2005.04.016
https://doi.org/10.1016/j.neuropharm.2005.04.016
Autor:
Buddy Pouw, Ying Zhang, Florence Hourcade Potelleret, Rae R. Matsumoto, Aisha L. Mack, Wayne D. Bowen
Publikováno v:
Pharmacology Biochemistry and Behavior. 77:775-781
Earlier studies show that antagonism of sigma receptors using high to moderate affinity compounds or antisense oligodeoxynucleotides targeting the sigma(1) subtype significantly attenuates the behavioral effects of cocaine in mice. In this study, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a977bc022eeddb121662ecb75a414285
https://doi.org/10.1016/j.pbb.2004.01.014
https://doi.org/10.1016/j.pbb.2004.01.014
Autor:
Michele J Friedman, Buddy Pouw, Brian R. de Costa, Wayne D. Bowen, Kari A. McCracken, Rae R. Matsumoto
Publikováno v:
European Journal of Pharmacology. 419:163-174
Cocaine's ability to interact with sigma receptors suggests that these proteins mediate some of its behavioral effects. Therefore, three novel sigma receptor ligands with antagonist activity were evaluated in Swiss Webster mice: BD1018 (3S-1-[2-(3,4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfed305305303566aa4c3a4fc0a6e73
https://doi.org/10.1016/s0014-2999(01)00968-2
https://doi.org/10.1016/s0014-2999(01)00968-2
Autor:
Rae R. Matsumoto, Buddy Pouw
Publikováno v:
European Journal of Pharmacology. 401:155-160
Acute dystonic reactions are motor side effects that occur soon after the initiation of neuroleptic treatment. Although earlier studies indicate that these abnormal movements can be induced in animals and humans via activation of sigma receptors, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4c7208f334b18db270c91872a30753
https://doi.org/10.1016/s0014-2999(00)00430-1
https://doi.org/10.1016/s0014-2999(00)00430-1
Publikováno v:
European Journal of Pharmacology. 386:181-186
Prior studies demonstrate that NMDA receptor antagonists attenuate cocaine-induced convulsions and lethality. Since glutamate is the primary neurotransmitter for NMDA receptors, pharmacological interventions to lower glutamatergic activity through no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803115236e409f3583aa5afd273e1625
https://doi.org/10.1016/s0014-2999(99)00740-2
https://doi.org/10.1016/s0014-2999(99)00740-2
Publikováno v:
Journal of Medicinal Chemistry. 41:2380-2389
A series of 2beta-substituted analogues of 4'-iodococaine (3) was synthesized and evaluated in an in vitro dopamine transporter (DAT) binding assay. Selective hydrolysis at the 2beta-position of 3 gave the carboxylic acid 15 that served as the interm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b19ad2e1239596e4f238c7f7ba34163
https://doi.org/10.1021/jm980061w
https://doi.org/10.1021/jm980061w
Publikováno v:
Journal of Medicinal Chemistry. 40:2474-2481
Four analogs and two homologs of cocaine, designed as potent cocaine antagonists, were synthesized. The SN2 reaction between ecgonine methyl ester (13) or appropriately substituted piperidinol (19, 21) and appropriately substituted 4-iodobenzoyl chlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ef29f46b04493dc39078a2b71a10e9
https://doi.org/10.1021/jm970121i
https://doi.org/10.1021/jm970121i
Publikováno v:
ChemInform. 28
Four analogs and two homologs of cocaine, designed as potent cocaine antagonists, were synthesized. The SN2 reaction between ecgonine methyl ester (13) or appropriately substituted piperidinol (19, 21) and appropriately substituted 4-iodobenzoyl chlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::601896cb60a39d691339224ebb21fe10
https://doi.org/10.1002/chin.199748264
https://doi.org/10.1002/chin.199748264
Autor:
Amina Kausar, Buddy Pouw, Wanda Williams, Deborah L. Gilmore, Andrew Coop, Wayne D. Bowen, Rae R. Matsumoto
Publikováno v:
European journal of pharmacology. 492(1)
Previous studies have shown that BD1008 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine) and related analogs attenuate the toxicity and stimulant effects of cocaine through antagonism of σ receptors. In the present study, six
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75030744db0c2d70f47cf4b43a48514
https://pubmed.ncbi.nlm.nih.gov/15145701
https://pubmed.ncbi.nlm.nih.gov/15145701