Výsledky vyhledávání - "Buddy E. Cantrell"

Rapid parallel synthesis applied to the optimization of a series of potent nonpeptide neuropeptide Y-1 receptor antagonists

Autor: Dennis M. Zimmerman, Miles Goodman Siegel, Gary A. Koppel, David C. Hunden, Patric James Hahn, Michael P. Clay, Robert F. Bruns, Anne M. Van Abbema, Donald R. Gehlert, Paul L. Ornstein, Douglas W. Johnson, Hamideh Zarrinmayeh, Douglas A. Schober, Michael O. Chaney, Buddy E. Cantrell

Publikováno v: Tetrahedron. 55:11619-11639

This study describes the integrated application of parallel synthesis and computational chemistry to the design of potent nonpeptide antagonists for the neuropeptide Y-1 (NPY1) receptor. A lead molecule was modeled in the active site of the NPY1 rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::316f9687be5a7143efde2baaa0d17744
https://doi.org/10.1016/s0040-4020(99)00683-3

Zobrazit plný text záznamu

A stereoselective synthetic approach to N-alkyl-4β-methyl-5-phenylmorphans

Autor: S. Wayne Mascarella, Kenneth M. Gigstad, Jason P. Burgess, Buddy E. Cantrell, Scott E. Fix, James B. Thomas, Julie B. Cooper, F. Ivy Carroll, Dennis M. Zimmerman

Publikováno v: Tetrahedron Letters. 40:403-406

A convergent, highly stereoselective synthetic approach to N-alkyl-4β-methyl-5-phenylmorphans has been developed utilizing alkylation of the metalloenamine of N-alkyl-1,2,3,6-tetrahydro-4-phenylpyridines with 2-(chloromethyl)-3,5-dioxahex-1-ene (Oka

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::519fd4410b49ab8ad950d03e37f98dca
https://doi.org/10.1016/s0040-4039(98)02402-2

Zobrazit plný text záznamu

Synthesis of 9β-methyl-2-alkyl-7-oxo-5-arylmorphans

Autor: Jason P. Burgess, Xiaoling Zheng, Buddy E. Cantrell, Dennis M. Zimmerman, F. Ivy Carroll, Scott E. Fix, Lawrence E. Brieaddy, James B. Thomas, S. Wayne Mascarella

Publikováno v: Tetrahedron Letters. 39:7001-7004

A convergent synthetic approach to 9β-methyl-2-alkyl-7-oxo-5-arylmorphans has been developed utilizing alkylation of the metalloenamine of 1,2,3,6-tetrahydro-4-aryl-1-alkylpyridines with 2-(chloromethyl)-3,5-dioxahex-1-ene (Okahara's reagent).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9242a7e3143c1d5c1ebab9d043e03127
https://doi.org/10.1016/s0040-4039(98)01549-4

Zobrazit plný text záznamu

Synthesis of a Series of Aryl Kainic Acid Analogs and Evaluation in Cells Stably Expressing the Kainate Receptor humGluR6

Autor: Dennis M. Zimmerman, Joseph P. Tizzano, Rajender K. Kamboj, Louise N. Farrell, Ken H. Hoo, David Bleakman, James A. Monn, Buddy E. Cantrell, Ian A. Pullar

Publikováno v: Journal of Medicinal Chemistry. 39:3617-3624

The synthesis and pharmacological characterization of a novel series of 4-aryl-substituted kainic acid analogs are described. Receptor affinities were determined on recombinantly expressed humGluR6 kainate receptors and on [3H]kainate binding to rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50931c9a23742a936d57753d418cca31
https://doi.org/10.1021/jm960155a

Zobrazit plný text záznamu

Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility Disorders

Autor: Darryle Darwin Schoepp, Buddy E. Cantrell, J. S. Gidda, Dennis M. Zimmerman, J. D. Leander, B G Johnson

Publikováno v: Journal of Medicinal Chemistry. 37:2262-2265

Structure-activity relationship studies were pursued within N-substituted-trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines in an effort to discover a peripherally selective opioid antagonist with high activity following systemic administration. Alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b5e69bdcbb57290260d230f90eb356
https://doi.org/10.1021/jm00041a003

Zobrazit plný text záznamu

3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity

Autor: Laurane G. Mendelsohn, B G Johnson, A E Takemori, J D Leander, W N Shaw, J D Snoddy, Jon K. Reel, David T.W. Wong, Buddy E. Cantrell, Charles H. Mitch

Publikováno v: Journal of Medicinal Chemistry. 36:2842-2850

A series of (3R*,4R*)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists with varying substituents on the nitrogen were evaluated for their effect on food consumption in obese Zucker rats. Opioid affinity (mu, kappa, and delta for selected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22faa681e06223eecbccf3101cfbb93a
https://doi.org/10.1021/jm00072a002

Zobrazit plný text záznamu