Genomic investigations of unexplained acute hepatitis in children

Autor: Morfopoulou, S, Buddle, S, Torres Montaguth, OE, Atkinson, L, Guerra-Assunção, JA, Moradi Marjaneh, M, Zennezini Chiozzi, R, Storey, N, Campos, L, Hutchinson, JC, Counsell, JR, Pollara, G, Roy, S, Venturini, C, Antinao Diaz, JF, Siam, A, Tappouni, LJ, Asgarian, Z, Ng, J, Hanlon, KS, Lennon, A, McArdle, A, Czap, A, Rosenheim, J, Andrade, C, Anderson, G, Lee, JCD, Williams, R, Williams, CA, Tutill, H, Bayzid, N, Martin Bernal, LM, Macpherson, H, Montgomery, K-A, Moore, C, Templeton, K, Neill, C, Holden, M, Gunson, R, Shepherd, SJ, Shah, P, Cooray, S, Voice, M, Steele, M, Fink, C, Whittaker, TE, Santilli, G, Gissen, P, Kaufer, BB, Reich, J, Andreani, J, Simmonds, P, Alrabiah, DK, Castellano, S, Chikowore, P, Odam, M, Rampling, T, Houlihan, C, Hoschler, K, Talts, T, Celma, C, Gonzalez, S, Gallagher, E, Simmons, R, Watson, C, Mandal, S, Zambon, M, Chand, M, Hatcher, J, De, S, Baillie, K, Semple, MG, DIAMONDS Consortium, PERFORM Consortium, ISARIC 4C Investigators, Martin, J, Ushiro-Lumb, I, Noursadeghi, M, Deheragoda, M, Hadzic, N, Grammatikopoulos, T, Brown, R, Kelgeri, C, Thalassinos, K, Waddington, SN, Jacques, TS, Thomson, E, Levin, M, Brown, JR, Breuer, J

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::6795ba5b71c0ade985a1f9cf7bd26084
http://hdl.handle.net/10044/1/105327

Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses.

Autor: Buddle S; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Forrest L; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Akinsuyi N; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Martin Bernal LM; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Brooks T; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Venturini C; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Miller C; Department of Microbiology, Virology and Infection Prevention & Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Brown JR; Department of Microbiology, Virology and Infection Prevention & Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Storey N; Department of Microbiology, Virology and Infection Prevention & Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Atkinson L; Department of Microbiology, Virology and Infection Prevention & Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Best T; Department of Microbiology, Virology and Infection Prevention & Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Roy S; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Goldsworthy S; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Castellano S; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Simmonds P; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Harvala H; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Division of Infection and Immunity, University College London, London, UK.; Microbiology Services, NHS Blood and Transplant, Colindale, UK., Golubchik T; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Sydney Infectious Diseases Institute, Faculty of Medicine and Health, University of Sydney, Sydney, Australia., Williams R; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Breuer J; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK. j.breuer@ucl.ac.uk.; Department of Microbiology, Virology and Infection Prevention & Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. j.breuer@ucl.ac.uk., Morfopoulou S; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK. sofia.morfopoulou.10@ucl.ac.uk.; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK. sofia.morfopoulou.10@ucl.ac.uk., Torres Montaguth OE; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK. oscar.torres@ucl.ac.uk.

Publikováno v: Genome medicine [Genome Med] 2024 Sep 09; Vol. 16 (1), pp. 111. Date of Electronic Publication: 2024 Sep 09.

Genomic investigations of unexplained acute hepatitis in children.

Autor: Morfopoulou S; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK.; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Buddle S; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Torres Montaguth OE; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Atkinson L; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Guerra-Assunção JA; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Moradi Marjaneh M; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK.; Section of Virology, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Zennezini Chiozzi R; University College London Mass Spectrometry Science Technology Platform, Division of Biosciences, University College London, London, UK., Storey N; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Campos L; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Hutchinson JC; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Counsell JR; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Pollara G; Division of Infection and Immunity, University College London, London, UK., Roy S; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Venturini C; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Antinao Diaz JF; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Siam A; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK.; Gene Transfer Technology Group, EGA-Institute for Women's Health, University College London, London, UK., Tappouni LJ; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Asgarian Z; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Ng J; Gene Transfer Technology Group, EGA-Institute for Women's Health, University College London, London, UK., Hanlon KS; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Lennon A; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., McArdle A; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Czap A; Division of Infection and Immunity, University College London, London, UK., Rosenheim J; Division of Infection and Immunity, University College London, London, UK., Andrade C; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Anderson G; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Lee JCD; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Williams R; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Williams CA; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Tutill H; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Bayzid N; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Martin Bernal LM; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Macpherson H; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, UK., Montgomery KA; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, UK., Moore C; Wales Specialist Virology Centre, Public Health Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK., Templeton K; Department of Medical Microbiology, Edinburgh Royal Infirmary, Edinburgh, UK., Neill C; Public Health Agency Northern Ireland, Belfast, UK., Holden M; School of Medicine, University of St. Andrews, St. Andrews, UK.; Public Health Scotland, Edinburgh, UK., Gunson R; West of Scotland Specialist Virology Centre, Glasgow, UK., Shepherd SJ; West of Scotland Specialist Virology Centre, Glasgow, UK., Shah P; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Cooray S; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Voice M; Micropathology Ltd, University of Warwick Science Park, Coventry, UK., Steele M; Micropathology Ltd, University of Warwick Science Park, Coventry, UK., Fink C; Micropathology Ltd, University of Warwick Science Park, Coventry, UK., Whittaker TE; Molecular and Cellular Immunology, Great Ormond Street Institute of Child Health, University College London, London, UK., Santilli G; Molecular and Cellular Immunology, Great Ormond Street Institute of Child Health, University College London, London, UK., Gissen P; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Kaufer BB; Institute of Virology, Freie Universität Berlin, Berlin, Germany., Reich J; Institute of Virology, Freie Universität Berlin, Berlin, Germany., Andreani J; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre Hospitalier Universitaire (CHU) Grenoble-Alpes, Grenoble, France., Simmonds P; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Alrabiah DK; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.; National Centre for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Castellano S; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.; University College London Genomics, University College London, London, UK., Chikowore P; Roslin Institute, University of Edinburgh, Edinburgh, UK., Odam M; Roslin Institute, University of Edinburgh, Edinburgh, UK., Rampling T; Division of Infection and Immunity, University College London, London, UK.; UK Health Security Agency, London, UK.; Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK., Houlihan C; Division of Infection and Immunity, University College London, London, UK.; UK Health Security Agency, London, UK.; Department of Clinical Virology, University College London Hospitals, London, UK., Hoschler K; UK Health Security Agency, London, UK., Talts T; UK Health Security Agency, London, UK., Celma C; UK Health Security Agency, London, UK., Gonzalez S; UK Health Security Agency, London, UK., Gallagher E; UK Health Security Agency, London, UK., Simmons R; UK Health Security Agency, London, UK., Watson C; UK Health Security Agency, London, UK., Mandal S; UK Health Security Agency, London, UK., Zambon M; UK Health Security Agency, London, UK., Chand M; UK Health Security Agency, London, UK., Hatcher J; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., De S; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Baillie K; Roslin Institute, University of Edinburgh, Edinburgh, UK., Semple MG; Pandemic Institute, University of Liverpool, Liverpool, UK.; Respiratory Medicine, Alder Hey Children's Hospital NHS Foundation Trust, Liverpool, UK., Martin J; Centre for Genomics and Child Health, The Blizard Institute, Queen Mary University of London, London, UK., Ushiro-Lumb I; NHS Blood and Transplant, Bristol, UK., Noursadeghi M; Division of Infection and Immunity, University College London, London, UK., Deheragoda M; King's College Hospital, London, UK., Hadzic N; King's College Hospital, London, UK., Grammatikopoulos T; King's College Hospital, London, UK., Brown R; Department of Cellular Pathology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Kelgeri C; Liver Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK., Thalassinos K; University College London Mass Spectrometry Science Technology Platform, Division of Biosciences, University College London, London, UK.; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK.; Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, UK., Waddington SN; Gene Transfer Technology Group, EGA-Institute for Women's Health, University College London, London, UK.; Medical Research Council Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witswatersrand, Johannesburg, South Africa., Jacques TS; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; Developmental Biology and Cancer Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Thomson E; Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK., Levin M; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Brown JR; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Breuer J; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK. j.breuer@ucl.ac.uk.; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. j.breuer@ucl.ac.uk.

Publikováno v: Nature [Nature] 2023 May; Vol. 617 (7961), pp. 564-573. Date of Electronic Publication: 2023 Mar 30.