Myoferlin: A Potential Marker of Response to Radiation Therapy and Survival in Locally Advanced Rectal Cancer.

Autor: Fowler H; Department of Colorectal Surgery, Countess of Chester National Health Service Foundation Trust, Chester, United Kingdom; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, William Henry Duncan Building, Liverpool, United Kingdom. Electronic address: Hayleyfowler@doctors.org.uk., Clifford RE; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, William Henry Duncan Building, Liverpool, United Kingdom., Bowden D; Department of Colorectal Surgery, Countess of Chester National Health Service Foundation Trust, Chester, United Kingdom., Sutton PA; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, William Henry Duncan Building, Liverpool, United Kingdom., Govindarajah N; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, William Henry Duncan Building, Liverpool, United Kingdom., Fok M; Department of Colorectal Surgery, Countess of Chester National Health Service Foundation Trust, Chester, United Kingdom; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, William Henry Duncan Building, Liverpool, United Kingdom., Glenn M; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, William Henry Duncan Building, Liverpool, United Kingdom., Wall M; Department of Colorectal Surgery, Countess of Chester National Health Service Foundation Trust, Chester, United Kingdom., Rubbi C; Faculty of Health, Social Care & Medicine, Edge Hill University, St Helens Road, Ormskirk, Lancashire, L39 4QP., Buczacki SJA; Nuffield Department of Surgical Sciences (NDS), University of Oxford, Oxford, United Kingdom., Mandal A; Nuffield Department of Surgical Sciences (NDS), University of Oxford, Oxford, United Kingdom., Francies H; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Hughes J; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Parsons JL; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom., Vimalachandran D; Department of Colorectal Surgery, Countess of Chester National Health Service Foundation Trust, Chester, United Kingdom; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, William Henry Duncan Building, Liverpool, United Kingdom.

Publikováno v: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2024 Nov 15; Vol. 120 (4), pp. 1111-1123. Date of Electronic Publication: 2024 Jun 10.

Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in neighbouring wildtype cells.

Autor: Chan DKH; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, Singapore, Singapore., Mandal A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Hester S; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK., Yu Z; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.; Nuffield Department of Medicine, Chinese Academy for Medical Sciences Oxford Institute, University of Oxford, Oxford, UK., Higgins GS; Department of Oncology, University of Oxford, Oxford, UK., Kessler BM; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.; Nuffield Department of Medicine, Chinese Academy for Medical Sciences Oxford Institute, University of Oxford, Oxford, UK., Fischer R; Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.; Nuffield Department of Medicine, Chinese Academy for Medical Sciences Oxford Institute, University of Oxford, Oxford, UK., Buczacki SJA; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. simon.buczacki@nds.ox.ac.uk.

Publikováno v: Cell death discovery [Cell Death Discov] 2023 Jun 29; Vol. 9 (1), pp. 200. Date of Electronic Publication: 2023 Jun 29.

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

Autor: Brevini T; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. tb647@cam.ac.uk., Maes M; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Webb GJ; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., John BV; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA., Fuchs CD; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Buescher G; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Wang L; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Griffiths C; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Brown ML; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Scott WE 3rd; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Pereyra-Gerber P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Gelson WTH; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Brown S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Dillon S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Muraro D; Wellcome Sanger Institute, Hinxton, UK., Sharp J; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Neary M; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Box H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Tatham L; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Stewart J; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Curley P; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Pertinez H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Forrest S; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Mlcochova P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA., Varankar SS; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Darvish-Damavandi M; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Mulcahy VL; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK., Kuc RE; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Williams TL; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Heslop JA; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Rossetti D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Tysoe OC; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Galanakis V; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Vila-Gonzalez M; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Crozier TWM; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Bargehr J; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Sinha S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Fear C; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Swift L; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Davies SE; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Wester A; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden., Hagström H; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden., Melum E; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Hybrid Technology Hub Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway., Clements D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Humphreys P; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Herriott J; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Kijak E; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Cox H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Bramwell C; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Valentijn A; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Illingworth CJR; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.; Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK., Dahman B; Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA., Bastaich DR; Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA., Ferreira RD; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA., Marjot T; Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK., Barnes E; Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK., Moon AM; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA., Barritt AS 4th; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA., Gupta RK; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Baker S; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Davenport AP; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Corbett G; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Gorgoulis VG; Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Buczacki SJA; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Lee JH; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.; NHS Blood and Transplant, Cambridge, UK., Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Fisher AJ; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Gibbs P; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Butler AJ; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Watson CJE; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre, and the NIHR Blood and Transplant Research Unit (BTRU) at the University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT), Cambridge, UK., Mells GF; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK., Dougan G; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Owen A; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Lohse AW; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Vallier L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. ludovic.vallier@bih-charite.de.; Wellcome Sanger Institute, Hinxton, UK. ludovic.vallier@bih-charite.de.; Berlin Institute of Health (BIH), BIH Centre for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Berlin, Germany. ludovic.vallier@bih-charite.de.; Max Planck Institute for Molecular Genetics, Berlin, Germany. ludovic.vallier@bih-charite.de., Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. fs347@cam.ac.uk.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. fs347@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. fs347@cam.ac.uk.

Publikováno v: Nature [Nature] 2023 Mar; Vol. 615 (7950), pp. 134-142. Date of Electronic Publication: 2022 Dec 05.

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.

Autor: Robinson PS; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK., Thomas LE; Institute of Life Science, Swansea University, Swansea, SA28PP, UK., Abascal F; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Jung H; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Harvey LMR; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., West HD; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Olafsson S; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lee BCH; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Coorens THH; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lee-Six H; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Butlin L; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Lander N; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Truscott R; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Sanders MA; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Haematology, Erasmus University Medical Centre, 3015 CN, Rotterdam, The Netherlands., Lensing SV; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Buczacki SJA; Nuffield Department of Surgical Sciences, Medical Sciences Division, University of Oxford, Oxford, UK., Ten Hoopen R; Department of Oncology, University of Cambridge, Cambridge, UK., Coleman N; Department of Pathology, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Brunton-Sim R; Norfolk and Norwich University Hospital, Norwich, UK., Rushbrook S; Norfolk and Norwich University Hospital, Norwich, UK.; Norwich Medical School, University of East Anglia, Norwich, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.; Cambridge NIHR Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Lalloo F; Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Oxford Road, Manchester, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Martincorena I; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Sampson JR; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Stratton MR; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK. mrs@sanger.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Jul 08; Vol. 13 (1), pp. 3949. Date of Electronic Publication: 2022 Jul 08.

Mutational landscape of normal epithelial cells in Lynch Syndrome patients.

Autor: Lee BCH; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Robinson PS; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK., Coorens THH; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Yan HHN; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Olafsson S; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lee-Six H; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Sanders MA; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Siu HC; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Hewinson J; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Yue SSK; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Tsui WY; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Chan ASY; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Chan AKW; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Ho SL; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Campbell PJ; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Martincorena I; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Buczacki SJA; Nuffield Department of Surgical Sciences, University of Oxford, Headington, Oxford, OX3 7DQ, UK., Yuen ST; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Leung SY; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong. suetyi@hku.hk.; Centre for PanorOmic Sciences, The University of Hong Kong, Pokfulam, Hong Kong. suetyi@hku.hk., Stratton MR; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK. mrs@sanger.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 May 17; Vol. 13 (1), pp. 2710. Date of Electronic Publication: 2022 May 17.