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Macrophages form a protective cellular barrier in joints

Autor: Buckley, CD

Publikováno v: Nature. 572:590-592

Inflammation and the repair of damaged tissues are regulated by immune cells called macrophages. The finding that they form a layer that shields mouse joints from damage has implications for the treatment of arthritis. A cell layer in joints forms a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f414329744230abde3f78ea72ae68e9
https://doi.org/10.1038/d41586-019-02340-x

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11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy

Autor: Fenton, CG, Doig, CL, Fareed, S, Naylor, A, Morrell, AP, Addison, O, Wehmeyer, C, Buckley, CD, Cooper, MS, Lavery, GG, Raza, K, Hardy, RS

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019)
Arthritis Research & Therapy

Background Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects including glucocorticoid-induced osteoporosis (GIOP). 11β-Hydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::58978ca16230f1d7aa3c6ebf9c9d9cab
https://publications.aston.ac.uk/id/eprint/40152/1/trabecular_bone_loss.pdf

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11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

Autor: Hardy, RS, Fenton, C, Croft, AP, Naylor, AJ, Begum, R, Desanti, G, Buckley, CD, Lavery, G, Cooper, MS, Raza, K

Publikováno v: Journal of Autoimmunity

Objective In rheumatoid arthritis, the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is highly expressed at sites of inflammation, where it converts inactive glucocorticoids (GC) to their active counterparts. In conditions of GC exce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d89ee43216355dedf474d246904878a5
https://ora.ox.ac.uk/objects/uuid:4a4f9eee-29d7-43ac-bf1e-c516da321835

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Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Autor: Zhang, F, Wei, K, Slowikowski, K, Fonseka, CY, Rao, DA, Kelly, S, Goodman, SM, Tabechian, D, Hughes, LB, Salomon-Escoto, K, Watts, GFM, Jonsson, AH, Rangel-Moreno, J, Meednu, N, Rozo, C, Apruzzese, W, Eisenhaure, TM, Lieb, DJ, Boyle, DL, Mandelin, AM, Albrecht, J, Bridges, SL, Buckley, CD, Buckner, JH, Dolan, J, Guthridge, JM, Gutierrez-Arcelus, M, Ivashkiv, LB, James, EA, James, JA, Keegan, J, Lee, YC, McGeachy, MJ, McNamara, MA, Mears, JR, Mizoguchi, F, Nguyen, JP, Noma, A, Orange, DE, Rohani-Pichavant, M, Ritchlin, C, Robinson, WH, Seshadri, A, Sutherby, D, Seifert, J, Turner, JD, Utz, PJ, Boyce, BF, Dicarlo, E, Gravallese, EM, Gregersen, PK, Moreland, L, Firestein, GS, Hacohen, N, Nusbaum, C, Lederer, JA, Perlman, H, Pitzalis, C, Filer, A, Holers, VM, Bykerk, VP, Donlin, LT, Anolik, JH, Brenner, MB, Raychaudhuri, S

Publikováno v: Nature immunology

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibrobl

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http://ora.ox.ac.uk/objects/uuid:

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Endogenous Galectin-9 Suppresses Apoptosis in Human Rheumatoid Arthritis Synovial Fibroblasts

Autor: Pearson, MJ, Bik, MA, Ospelt, C, Naylor, AJ, Wehmeyer, C, Jones, SW, Buckley, CD, Gay, S, Filer, A, Lord, JM

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports

Galectin-9 (Gal9) has been postulated to have anti-inflammatory properties based on the ability of exogenous Gal9 to induce apoptosis in synovial fibroblasts in animal models of rheumatoid arthritis (RA). Here we aimed to assess the potential role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7105d125991e49678ffb6836f1cddbed
https://www.zora.uzh.ch/id/eprint/153499/

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Patients' perceptions of their relatives' risk of developing rheumatoid arthritis and of the potential for risk communication, prediction, and modulation

Autor: Falahee, M, Simons, G, Buckley, CD, Hansson, M, Stack, RJ, Raza, K

Objectives To understand the perspectives of patients with rheumatoid arthritis (RA) about the risk of their relatives developing RA in the future, and about communicating with their relatives about risk and its modulation. Methods Twenty-one RA pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f6885fe9513c45c224488dd93d05849f
https://ora.ox.ac.uk/objects/uuid:abf3fd21-a193-49f9-aab1-310b3438f8be

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A qualitative exploration of physical, mental and ocular fatigue in patients with primary Sjögren's Syndrome

Autor: Stack, RJ, Southworth, S, Fisher, BA, Barone, F, Buckley, CD, Rauz, S, Bowman, SJ

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0187272 (2017)
PLoS ONE

Introduction Primary SjoÈgren's Syndrome (pSS) affects exocrine glands such as those producing the tear film, leading to dry and painful eyes, but is also associated with fatigue. The experience of fatigue in pSS, and its relationship with sicca sym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::177d459501434571ceb53ab35bae53dc
https://doaj.org/article/aba0f17e1c3f41d48df9bdf38e9143dd

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