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pro vyhledávání: '"Buchanan Ki"'
Autor:
Jeremy J. Lambert, McPhail P, John A. Peters, Sansbury Fh, Muntoni A, Hutchinson Ej, Bennett Dj, Donald F. M. Stevenson, Maurice S. Maidment, Alison Anderson, Feilden H, Miller S, Ross McGuire, Cooke A, Delia Belelli, Buchanan Ki, Casula A, Sundaram H, Gemmell Dk, Hamilton Nm
Publikováno v:
Journal of medicinal chemistry. 44(22)
In the search for a novel water-soluble general anesthetic agent the activity of an alpha-amino acid phenolic ester lead, identified from patent literature, was markedly improved. In addition to improving in vivo activity in mice, good in vitro activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87da07924e6ad3ef11ef0fa697b565d
https://pubmed.ncbi.nlm.nih.gov/11606122
https://pubmed.ncbi.nlm.nih.gov/11606122
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Akademický článek
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Autor:
Green SR; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Davis SH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Damerow S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Engelhart CA; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Mathieson M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Baragaña B; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Robinson DA; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Tamjar J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Dawson A; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Tamaki FK; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Buchanan KI; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Post J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Dowers K; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Shepherd SM; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Jansen C; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Zuccotto F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Epemolu O; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Riley J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Stojanovski L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Osuna-Cabello M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Pérez-Herrán E; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Rebollo MJ; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Guijarro López L; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Casado Castro P; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Camino I; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Kim HC; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Bean JM; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Nahiyaan N; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Rhee KY; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Wang Q; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD, USA., Tan VY; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD, USA., Boshoff HIM; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD, USA., Converse PJ; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Li SY; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Chang YS; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Fotouhi N; Global Alliance for TB Drug Development, New York, NY, USA., Upton AM; Global Alliance for TB Drug Development, New York, NY, USA., Nuermberger EL; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Schnappinger D; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Read KD; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Encinas L; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Bates RH; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Wyatt PG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Cleghorn LAT; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK. l.a.t.cleghorn@dundee.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2022 Oct 11; Vol. 13 (1), pp. 5992. Date of Electronic Publication: 2022 Oct 11.
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
Autor:
Soares de Melo C; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Singh V; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa., Myrick A; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa., Simelane SB; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Taylor D; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa., Brunschwig C; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa., Lawrence N; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa., Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States., Engelhart CA; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States., Kumar A; Infectious Disease Research Institute, 1616 Eastlake Ave E, Suite 400, Seattle, Washington 98102, United States., Parish T; Infectious Disease Research Institute, 1616 Eastlake Ave E, Suite 400, Seattle, Washington 98102, United States., Su Q; Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Myers TG; Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Boshoff HIM; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Barry CE 3rd; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Sirgel FA; South African Medical Research Council Centre for Tuberculosis Research/DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Science, Stellenbosch University, Tygerberg 7505, South Africa., van Helden PD; South African Medical Research Council Centre for Tuberculosis Research/DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Science, Stellenbosch University, Tygerberg 7505, South Africa., Buchanan KI; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Bayliss T; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Green SR; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Ray PC; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Wyatt PG; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Basarab GS; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa., Eyermann CJ; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Chibale K; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa., Ghorpade SR; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2021 Jan 14; Vol. 64 (1), pp. 719-740. Date of Electronic Publication: 2021 Jan 04.
Autor:
Park Y; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States., Pacitto A; Department of Biochemistry, University of Cambridge , Cambridge CB2 1GA, United Kingdom., Bayliss T; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Cleghorn LA; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Wang Z; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College , New York, New York 10065, United States., Hartman T; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College , New York, New York 10065, United States., Arora K; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States., Ioerger TR; Department of Computer Science and Engineering, Texas A&M University , College Station, Texas 77843, United States., Sacchettini J; Department of Biochemistry & Biophysics, Texas A&M University , College Station, Texas 77843, United States., Rizzi M; Dipartimento di Scienze del Farmaco, University of Piemonte Orientale , Via Bovio 6, 28100 Novara, Italy., Donini S; Dipartimento di Scienze del Farmaco, University of Piemonte Orientale , Via Bovio 6, 28100 Novara, Italy., Blundell TL; Department of Biochemistry, University of Cambridge , Cambridge CB2 1GA, United Kingdom., Ascher DB; Department of Biochemistry, University of Cambridge , Cambridge CB2 1GA, United Kingdom., Rhee K; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College , New York, New York 10065, United States., Breda A; Department of Biochemistry & Biophysics, Texas A&M University , College Station, Texas 77843, United States., Zhou N; Department of Biochemistry & Biophysics, Texas A&M University , College Station, Texas 77843, United States., Dartois V; Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey , Newark, New Jersey 07103, United States., Jonnala SR; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States., Via LE; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States.; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Rondebosch 7700, South Africa., Mizrahi V; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Rondebosch 7700, South Africa., Epemolu O; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Stojanovski L; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Simeons F; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Osuna-Cabello M; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Ellis L; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., MacKenzie CJ; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Smith AR; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Davis SH; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Murugesan D; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Buchanan KI; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Turner PA; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Huggett M; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Zuccotto F; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Rebollo-Lopez MJ; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Lafuente-Monasterio MJ; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Sanz O; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Diaz GS; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Lelièvre J; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Ballell L; Diseases of the Developing World, GlaxoSmithKline , Calle Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain., Selenski C; GlaxoSmithKline , 5 Crescent Drive, Philadelphia, Pennsylvania 19112, United States., Axtman M; GlaxoSmithKline , 5 Crescent Drive, Philadelphia, Pennsylvania 19112, United States., Ghidelli-Disse S; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Pflaumer H; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Bösche M; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Drewes G; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Freiberg GM; AbbVie Molecular Characterization , 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kurnick MD; AbbVie Molecular Characterization , 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Srikumaran M; AbbVie Molecular Characterization , 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Kempf DJ; AbbVie Molecular Characterization , 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Green SR; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Ray PC; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Read K; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Wyatt P; Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee , Dundee DD1 5EH, United Kingdom., Barry CE 3rd; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States.; MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Rondebosch 7700, South Africa., Boshoff HI; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health , Bethesda, Maryland 20892-3206, United States.
Publikováno v:
ACS infectious diseases [ACS Infect Dis] 2017 Jan 13; Vol. 3 (1), pp. 18-33. Date of Electronic Publication: 2016 Oct 17.
Autor:
Cowley PM; Department of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK. phillip.cowley@tppgd.com, Baker J, Buchanan KI, Carlyle I, Clark JK, Clarkson TR, Deehan M, Edwards D, Kiyoi Y, Martin I, Osbourn D, Walker G, Ward N, Wishart G
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Apr 01; Vol. 21 (7), pp. 2034-9. Date of Electronic Publication: 2011 Feb 19.
Autor:
Cowley PM; Department of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK. phillip.cowley@merck.com, Baker J, Barn DR, Buchanan KI, Carlyle I, Clark JK, Clarkson TR, Deehan M, Edwards D, Goodwin RR, Jaap D, Kiyoi Y, Mort C, Palin R, Prosser A, Walker G, Ward N, Wishart G, Young T
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Jan 01; Vol. 21 (1), pp. 497-501. Date of Electronic Publication: 2010 Oct 26.