Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer

Autor: Lascorz Jesus, Bevier Melanie, Schönfels Witigo V, Kalthoff Holger, Aselmann Heiko, Beckmann Jan, Egberts Jan, Buch Stephan, Becker Thomas, Schreiber Stefan, Hampe Jochen, Hemminki Kari, Försti Asta, Schafmayer Clemens

Publikováno v: BMC Medical Genetics, Vol 13, Iss 1, p 31 (2012)

Abstract Background Currently, the TNM classification of malignant tumours based on clinicopathological staging remains the standard for colorectal cancer (CRC) prognostication. Recently, we identified the mitochondrial oxidative phosphorylation chai

Externí odkaz: https://doaj.org/article/56b10cb0f53e4e999ff78242bac8b6a3

Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany

Autor: Fändrich Fred, Fölsch Ulrich R, Kremer Bernd, Timm Birgit, Seeger Markus, Buch Stephan, Völzke Henry, Freitag Sandra, Albers Stefan, Tepel Jürgen, Hartleb Jürgen, Schafmayer Clemens, Krawczak Michael, Schreiber Stefan, Hampe Jochen

Publikováno v: BMC Gastroenterology, Vol 6, Iss 1, p 36 (2006)

Abstract Background Gallstones represent a prevalent and costly health problem. The changing epidemiology and the emerging non-surgical interventions for gallstone disease necessitate the definition of target populations for future therapies. This st

Externí odkaz: https://doaj.org/article/e69d675be9294e7592b2e96ab16e6aac

Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects

Autor: Guo, Xingyi, Lin, Weiqiang, Wen, Wanqing, Huyghe, Jeroen, Bien, Stephanie, Cai, Qiuyin, Harrison, Tabitha, Chen, Zhishan, Qu, Conghui, Bao, Jiandong, Long, Jirong, Yuan, Yuan, Wang, Fangqin, Bai, Mengqiu, Abecasis, Goncalo R., Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bishop, D. Timothy, Brenner, Hermann, Buch, Stephan, Burnett-Hartman, Andrea, Campbell, Peter T., Castellví-Bel, Sergi, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Cho, Sang Hee, Conti, David V., Chapelle, Albert de la, Feskens, Edith J.M., Gallinger, Steven J., Giles, Graham G., Goodman, Phyllis J., Gsur, Andrea, Guinter, Mark, Gunter, Marc J., Hampe, Jochen, Hampel, Heather, Hayes, Richard B., Hoffmeister, Michael, Kampman, Ellen, Kang, Hyun Min, Keku, Temitope O., Kim, Hyeong Rok, Le Marchand, Loic, Lee, Soo Chin, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane, Milne, Roger L., Moreno, Victor, Murphy, Neil, Newcomb, Polly A., Nickerson, Deborah A., Offit, Kenneth, Pearlman, Rachel, Pharoah, Paul D.P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Schumacher, Fredrick R., Slattery, Martha L., Su, Yu-Ru, Tangen, Catherine M., Ulrich, Cornelia M., van Duijnhoven, Franzel J.B., Van Guelpen, Bethany, Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Wang, Xiaoliang, White, Emily, Wolk, Alicja, Woods, Michael O., Casey, Graham, Hsu, Li, Jenkins, Mark A., Gruber, Stephen B., Peters, Ulrike, Zheng, Wei

Publikováno v: In Gastroenterology March 2021 160(4):1164-1178

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study

Autor: Buch, Stephan, Innes, Hamish, Lutz, Philipp Ludwig, Nischalke, Hans Dieter, Marquardt, Jens U., Fischer, Janett, Weiss, Karl Heinz, Rosendahl, Jonas, Marot, Astrid, Krawczyk, Marcin, Casper, Markus, Lammert, Frank, Eyer, Florian, Vogel, Arndt, Marhenke, Silke, von Felden, Johann, Sharma, Rohini, Atkinson, Stephen Rahul, McQuillin, Andrew, Nattermann, Jacob, Schafmayer, Clemens, Franke, Andre, Strassburg, Christian, Rietschel, Marcella, Altmann, Heidi, Sulk, Stefan, Thangapandi, Veera Raghavan, Brosch, Mario, Lackner, Carolin, Stauber, Rudolf E, Canbay, Ali, Link, Alexander, Reiberger, Thomas, Mandorfer, Matthias, Semmler, Georg, Scheiner, Bernhard, Datz, Christian, Romeo, Stefano, Corradini, Stefano Ginanni, Irving, William Lucien, Morling, Joanne R, Guha, Indra Neil, Barnes, Eleanor, Ansari, M Azim, Quistrebert, Jocelyn, Valenti, Luca, Müller, Sascha A, Morgan, Marsha Yvonne, Dufour, Jean-François, Trebicka, Jonel, Berg, Thomas, Deltenre, Pierre, Mueller, Sebastian, Hampe, Jochen, Stickel, Felix

Objective: Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence

Externí odkaz: https://tud.qucosa.de/id/qucosa%3A89012
https://tud.qucosa.de/api/qucosa%3A89012/attachment/ATT-0/

Variants in PCSK7, PNPLA3 and TM6SF2 are risk factors for the development of cirrhosis in hereditary haemochromatosis.

Autor: Buch, Stephan¹ (AUTHOR), Sharma, Aneesh² (AUTHOR), Ryan, Eleanor³ (AUTHOR), Datz, Christian⁴ (AUTHOR), Griffiths, William J. H.⁵ (AUTHOR), Way, Michael² (AUTHOR), Buckley, Thomas W. M.² (AUTHOR), Ryan, John D.³ (AUTHOR), Stewart, Stephen³ (AUTHOR), Wright, Callum⁵ (AUTHOR), Dongiovanni, Paola⁶ (AUTHOR), Fracanzani, Anna⁶ (AUTHOR), Zwerina, Jochen^7,8 (AUTHOR), Merle, Uta⁹ (AUTHOR), Weiss, Karl Heinz⁹ (AUTHOR), Aigner, Elmar⁴ (AUTHOR), Krones, Elisabeth¹⁰ (AUTHOR), Dejaco, Christian^10,11 (AUTHOR), Fischer, Janett¹² (AUTHOR), Berg, Thomas¹² (AUTHOR)

Publikováno v: Alimentary Pharmacology & Therapeutics. Apr2021, Vol. 53 Issue 7, p830-843. 14p. 3 Charts, 4 Graphs.