Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Buc-Calderon P"'
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103404- (2024)
Healthy cells have developed a sophisticated network of antioxidant molecules to prevent the toxic accumulation of reactive oxygen species (ROS) generated by diverse environmental stresses. On the opposite, cancer cells often exhibit high levels of R
Externí odkaz:
https://doaj.org/article/8acf265d03074f3db8674694aad7be6c
Autor:
Christophe Glorieux, Cinthya Enríquez, Constanza González, Gabriela Aguirre-Martínez, Pedro Buc Calderon
Publikováno v:
Antioxidants, Vol 13, Iss 1, p 70 (2024)
Physiological concentrations of reactive oxygen species (ROS) play vital roles in various normal cellular processes, whereas excessive ROS generation is central to disease pathogenesis. The nuclear factor erythroid 2-related factor 2 (NRF2) is a crit
Externí odkaz:
https://doaj.org/article/3bb5b5c3677f4c80b64cfa479345457e
Autor:
Julio Benites, Jaime A. Valderrama, Álvaro Contreras, Cinthya Enríquez, Ricardo Pino-Rios, Osvaldo Yáñez, Pedro Buc Calderon
Publikováno v:
Molecules, Vol 28, Iss 11, p 4323 (2023)
A series of 2-phenylamino-3-acyl-1,4-naphtoquinones were evaluated regarding their in vitro antiproliferative activities using DU-145, MCF-7 and T24 cancer cells. Such activities were discussed in terms of molecular descriptors such as half-wave pote
Externí odkaz:
https://doaj.org/article/6d0ac64f46104f319b3147f8ab682f3a
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009854 (2022)
Adaptive sequential behavior is a hallmark of human cognition. In particular, humans can learn to produce precise spatiotemporal sequences given a certain context. For instance, musicians can not only reproduce learned action sequences in a context-d
Externí odkaz:
https://doaj.org/article/95df48191aa14812ad46f53a29668244
Autor:
Jaime A. Valderrama, Andrea Pérez-Herrera, Giulio G. Muccioli, Edmundo A. Venegas-Casanova, Rafael Jara-Aguilar, Pedro Buc Calderon, Julio Benites
Publikováno v:
Journal of Chemistry, Vol 2022 (2022)
Oximes are known for their anti-inflammatory, antimicrobial, antioxidant, and anticancer activities. Frequently, modification of biologically active carbonyl compounds into oximes leads to increased activity. The present study reports the reactivity
Externí odkaz:
https://doaj.org/article/896959ef273b400cb700e199f407e506
Autor:
Patricia Minchán-Herrera, Roberto O. Ybañez-Julca, Ivan M. Quispe-Díaz, Edmundo A. Venegas-Casanova, Rafael Jara-Aguilar, Felipe Salas, Liz Zevallos-Escobar, Osvaldo Yáñez, Ricardo Pino-Rios, Pedro Buc Calderon, Julio Benites
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1337 (2022)
Valeriana pilosa is usually employed in Peruvian folk medicine in the form of infusion to treat stomach pain, and has antispasmodic, relaxing, sleep-promoting, and sedative properties, as well as is an anti-inflammatory. In this study, Valeriana pilo
Externí odkaz:
https://doaj.org/article/49f7ae9475db45cea646a6f0f1b7187f
Autor:
David Ríos, Jaime A. Valderrama, Gonzalo Quiroga, Jonathan Michea, Felipe Salas, Eduardo Álvarez Duarte, Edmundo A. Venegas-Casanova, Rafael Jara-Aguilar, Carlos Navarro-Retamal, Pedro Buc Calderon, Julio Benites
Publikováno v:
Molecules, Vol 27, Iss 9, p 3035 (2022)
The high rates of morbidity and mortality due to fungal infections are associated with a limited antifungal arsenal and the high toxicity of drugs. Therefore, the identification of novel drug targets is challenging due to the several resemblances bet
Externí odkaz:
https://doaj.org/article/a20861244a1348beaf115a8aca16e743
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Pro-oxidant drugs have been proposed for treating certain cancers but the resistance developed by cancer cells to oxidative stress limits its potential use in clinics. To understand the mechanisms underlying resistance to oxidativ
Externí odkaz:
https://doaj.org/article/ce2e4987f30c4bcda50baa888562cb17
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Publikováno v:
Molecules, Vol 25, Iss 4, p 953 (2020)
A series of benzo[g]benzothiazolo[2,3-b]quinazoline-7,12-quinones were prepared from 2-acylnaphthohydroquinones and 2-aminobenzothiazoles and were evaluated for their in vitro antiproliferative activity. After screening using the MTT reduction assay,
Externí odkaz:
https://doaj.org/article/dc6b0c6360d54048894d547078d16a3d