Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus

Autor: Dong, J, Levine, DM, Buas, MF, Zhang, R, Onstad, L, Fitzgerald, RC, Stomach and Oesophageal Cancer Study (SOCS) Consortium, Corley, DA, Shaheen, NJ, Lagergren, J, Hardie, LJ, Reid, BJ, Iyer, PG, Risch, HA, Caldas, C, Caldas, I, Pharoah, PD, Liu, G, Gammon, MD, Chow, W-H, Bernstein, L, Bird, NC, Ye, W, Wu, AH, Anderson, LA, MacGregor, S, Whiteman, DC, Vaughan, TL, Thrift, AP

Publikováno v: Dong, J, Levine, D, Buas, M, Zhang, R, Onstad, L, Fitzgerald, R C, consortium, S A O C S, Corley, D A, Shaheen, N J, Lagergren, J, Hardie, L J, Reid, B J, Iyer, P G, Risch, H A, Caldas, C, Caldas, I, Pharoah, P D, Liu, G, Gammon, M D, Chow, W-H, Bernstein, L, Bird, N C, Ye, W, Wu, A H, Anderson, L A, Macgregor, S, Whiteman, D C, Vaughan, T L & Thrift, A 2018, ' Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus ', Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association . https://doi.org/10.1016/j.cgh.2018.03.007

Background & Aims: Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for esophageal adenocarcinoma (EA) and Barrett’s esophagus (BE). However, variants in these loci account for a small fraction of cases of EA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::447fd3561641347d5c536d75bbaee328
https://pure.qub.ac.uk/en/publications/2a42322e-0183-4f59-9170-608e0e4fa6bb

GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level.

Autor: Schröder J; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Chegwidden L; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Maj C; Center for Human Genetics, University Hospital of Marburg, Marburg, Germany., Gehlen J; Center for Human Genetics, University Hospital of Marburg, Marburg, Germany., Speller J; Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), Medical Faculty, University of Bonn, Bonn, Germany., Böhmer AC; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Borisov O; Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Bonn, Germany., Hess T; Center for Human Genetics, University Hospital of Marburg, Marburg, Germany., Kreuser N; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Venerito M; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany., Alakus H; Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany., May A; Department of Gastroenterology, Oncology and Pneumology, Asklepios Paulinen Clinic Wiesbaden, Wiesbaden, Germany., Gerges C; Department of Internal Medicine II, Evangelisches Krankenhaus Dusseldorf, Dusseldorf, Germany., Schmidt T; Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany., Thieme R; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Heider D; Department of Mathematics and Computer Science, University of Marburg, Marburg, Germany., Hillmer AM; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University Hospital Cologne, Cologne, Germany., Reingruber J; Center for Human Genetics, University Hospital of Marburg, Marburg, Germany., Lyros O; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Dietrich A; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Hoffmeister A; Department of Gastroenterology, University of Leipzig, Leipzig, Germany., Mehdorn M; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Lordick F; University Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Leipzig, Germany., Stocker G; University Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Leipzig, Germany., Hohaus M; Department for General and Visceral Surgery, Städt. Klinikum Dresden Friedrichstadt, Dresden, Germany., Reim D; Department of Surgery, Technical University of Munich, School of Medicine, Klinikum Rechts der Isar, München, Germany., Kandler J; Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Dusseldorf, Medical Faculty of Heinrich Heine University Dusseldorf, Dusseldorf, Germany., Müller M; Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, University Hospital Marburg and Philipps University, Marburg, Germany., Ebigbo A; Department of Gastroenterology, University Hospital Augsburg, Augsburg, Germany., Fuchs C; Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany., Bruns CJ; Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany., Hölscher AH; Department for General, Visceral and Trauma Surgery, Elisabeth-Krankenhaus-Essen GmbH, Essen, Germany., Lang H; Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany., Grimminger PP; Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany., Dakkak D; Department of Internal Medicine and Gastroenterology, Elisabeth Hospital Essen, Essen, Germany., Vashist Y; Medias Klinikum, Burghausen, Germany., May S; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Görg S; Institute of Transfusion Medicine, University Hospital of Schleswig-Holstein, Lübeck/Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Ellinghaus D; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Galavotti S; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Veits L; Institute of Pathology, Friedrich-Alexander-Universiät Erlangen-Nürnberg, Klinikum Bayreuth, Bayreuth, Germany., Weismüller J; Gastroenterologische Gemeinschaftspraxis, Koblenz, Germany., Dommermuth J; Gastroenterologische Gemeinschaftspraxis, Koblenz, Germany., Benner U; Gastroenterologische Gemeinschaftspraxis, Koblenz, Germany., Rösch T; Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Messmann H; Department of Gastroenterology, University Hospital Augsburg, Augsburg, Germany., Schumacher B; Department of Internal Medicine and Gastroenterology, Elisabeth Hospital Essen, Essen, Germany., Neuhaus H; Department of Internal Medicine II, Evangelisches Krankenhaus Dusseldorf, Dusseldorf, Germany., Schmidt C; Medical Clinic II (Gastroenterology, Hepatology, Endocrinology, Diabetology and Infektiology), Klinikum Fulda, University Medicine Marburg-Campus Fulda, Fulda, Germany.; Medical Faculty, Friedrich Schiller University Jena, Jena, Germany., Wissinowski TT; Center for Inner Medicine II, Klinikum Chemnitz gGmbH, Chemnitz, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Dong J; Division of Hematology and Oncology, Department of Medicine, Cancer Center, and Genomic Sciences & Precision Medicine Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Ong JS; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Buas MF; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., Thrift AP; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA., Vaughan TL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA., Tomlinson I; Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh, UK., Whiteman DC; Cancer Control, Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Fitzgerald RC; Medical Research Council (MRC) Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, Cambridgeshire, UK., Jankowski J; Comprehensive Clinical Trials Unit, University College London, London, UK., Vieth M; Institute of Pathology, Friedrich-Alexander-Universiät Erlangen-Nürnberg, Klinikum Bayreuth, Bayreuth, Germany., Mayr A; Institute of Medical Biometrics, Informatics and Epidemiology (IMBIE), Medical Faculty, University of Bonn, Bonn, Germany., Gharahkhani P; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., MacGregor S; Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Gockel I; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Palles C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Schumacher J; Center for Human Genetics, University Hospital of Marburg, Marburg, Germany johannes.schumacher@uni-marburg.de.

Publikováno v: Gut [Gut] 2023 Apr; Vol. 72 (4), pp. 612-623. Date of Electronic Publication: 2022 Jul 26.

eQTL Set-Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma.

Autor: Wang X; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., Gharahkhani P; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Levine DM; Department of Biostatistics, University of Washington, School of Public Health, Seattle, Washington., Fitzgerald RC; Medical Research Council (MRC) Cancer Unit, Hutchison-MRC Research, Centre, University of Cambridge, Cambridge, UK., Gockel I; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Corley DA; Division of Research, Kaiser Permanente Northern California, Oakland, California.; San Francisco Medical Center, Kaiser Permanente Northern California, San Francisco, California., Risch HA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut., Bernstein L; Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California., Chow WH; Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas., Onstad L; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., Shaheen NJ; Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina., Lagergren J; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Hardie LJ; Division of Epidemiology, University of Leeds, Leeds, UK., Wu AH; Department of Population and Public Health Sciences, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California., Pharoah PDP; Department of Oncology, University of Cambridge, Cambridge, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Liu G; Pharmacogenomic Epidemiology, Ontario Cancer Institute, Toronto, Ontario, Canada., Anderson LA; Department of Epidemiology and Public Health, Queen's University of Belfast, Royal Group of Hospitals, Northern Ireland., Iyer PG; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Gammon MD; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina., Caldas C; Cancer Research UK, Cambridge Institute, Cambridge, UK., Ye W; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden., Barr H; Department of Upper GI Surgery, Gloucestershire Royal Hospital, Gloucester, UK., Moayyedi P; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Harrison R; Department of Pathology, Leicester Royal Infirmary, Leicester, UK., Watson RGP; Department of Medicine, Institute of Clinical Science, Royal Victoria Hospital, Belfast, UK., Attwood S; Department of General Surgery, North Tyneside General Hospital, North Shields, UK., Chegwidden L; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Love SB; Centre for Statistics in Medicine and Oxford Clinical Trials Research Unit, Oxford, UK., MacDonald D; Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada., deCaestecker J; Digestive Diseases Centre, University Hospitals of Leicester, Leicester, UK., Prenen H; Oncology Department, University Hospital Antwerp, Edegem, Belgium., Ott K; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.; Department of General, Visceral and Thorax Surgery, RoMed Klinikum Rosenheim, Rosenheim, Germany., Moebus S; Institute for Urban Public Health, University Hospitals, University of Duisburg-Essen, Essen, Germany., Venerito M; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany., Lang H; Department of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany., Mayershofer R; Gastroenterologie am Burgweiher, Bonn, Germany., Knapp M; Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany., Veits L; Institute of Pathology, Friedrich-Alexander-University Erlangen-Nuremberg, Klinikum Bayreuth, Bayreuth, Germany., Gerges C; Department of Internal Medicine, Evangelisches Krankenhaus, Düsseldorf, Germany., Weismüller J; Gastroenterologische Gemeinschaftspraxis, Koblenz, Germany., Reeh M; Department of General, Visceral and Thoracic Surgery, Asklepios Harzklinik Goslar, Goslar, Germany., Nöthen MM; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany., Izbicki JR; General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Manner H; Department of Internal Medicine II, Frankfurt Hoechst Hospital, Frankfurt, Germany., Neuhaus H; Department of Internal Medicine, Evangelisches Krankenhaus, Düsseldorf, Germany., Rösch T; Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Böhmer AC; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany., Hölscher AH; Clinic for General, Visceral and Trauma Surgery, Contilia Center for Esophageal Diseases, Elisabeth Hospital Essen, Germany., Anders M; Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany.; Department of Gastroenterology and Interdisciplinary Endoscopy, Vivantes Wenckebach-Klinikum, Berlin, Germany., Pech O; Department of Gastroenterology and Interventional Endoscopy, St. John of God Hospital, Regensburg, Germany., Schumacher B; Department of Internal Medicine, Evangelisches Krankenhaus, Düsseldorf, Germany.; Department of Internal Medicine and Gastroenterology, Elisabeth Hospital, Essen, Germany., Schmidt C; Department of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany., Schmidt T; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany., Noder T; Department of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Lorenz D; Department of General and Visceral Surgery, Sana Klinikum, Offenbach, Germany., Vieth M; Institute of Pathology, Friedrich-Alexander-University Erlangen-Nuremberg, Klinikum Bayreuth, Bayreuth, Germany., May A; Department of Gastroenterology, Oncology and Pneumology, Asklepios Paulinen Klinik, Wiesbaden, Germany., Hess T; Center for Human Genetics, University Hospital of Marburg, Marburg, Germany., Kreuser N; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany., Becker J; Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany., Ell C; Department of Medicine II, Sana Klinikum, Offenbach, Germany., Tomlinson I; Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh, UK., Palles C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Jankowski JA; Comprehensive Clinical Trials Unit, University College London, London, UK., Whiteman DC; Cancer Control, QIMR Berghofer Medical Research Institute, Brisbane, Australia., MacGregor S; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Schumacher J; Center for Human Genetics, University Hospital of Marburg, Marburg, Germany., Vaughan TL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Department of Epidemiology, University of Washington, School of Public Health, Seattle, Washington., Buas MF; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Dai JY; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Department of Biostatistics, University of Washington, School of Public Health, Seattle, Washington.

Publikováno v: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2022 Sep 02; Vol. 31 (9), pp. 1735-1745.

Prioritization and functional analysis of GWAS risk loci for Barrett's esophagus and esophageal adenocarcinoma.

Autor: Chen J, Ali MW, Yan L, Dighe SG, Dai JY, Vaughan TL, Casey G, Buas MF

Publikováno v: Human molecular genetics [Hum Mol Genet] 2022 Feb 03; Vol. 31 (3), pp. 410-422.

Quantitative global lipidomics analysis of patients with ovarian cancer versus benign adnexal mass.

Autor: Buas MF; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. matthew.buas@roswellpark.org., Drescher CW; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA, 98109, USA., Urban N; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA, 98109, USA., Li CI; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA, 98109, USA., Bettcher L; Department of Anesthesiology and Pain Medicine, Northwest Metabolomics Research Center, University of Washington School of Medicine, 850 Republican Street, Seattle, WA, 98109, USA., Hait NC; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.; Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Moysich KB; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Odunsi K; Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA., Raftery D; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA, 98109, USA.; Department of Anesthesiology and Pain Medicine, Northwest Metabolomics Research Center, University of Washington School of Medicine, 850 Republican Street, Seattle, WA, 98109, USA., Yan L; Department of Bioinformatics and Biostatistics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. li.yan@roswellpark.org.

Publikováno v: Scientific reports [Sci Rep] 2021 Sep 13; Vol. 11 (1), pp. 18156. Date of Electronic Publication: 2021 Sep 13.