Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86.

Autor: Lasrado N; Beth Israel Deaconess Medical Center, Boston, MA, USA., Collier AY; Beth Israel Deaconess Medical Center, Boston, MA, USA., Hachmann NP; Beth Israel Deaconess Medical Center, Boston, MA, USA., Miller J; Beth Israel Deaconess Medical Center, Boston, MA, USA., Rowe M; Beth Israel Deaconess Medical Center, Boston, MA, USA., Schonberg ED; Beth Israel Deaconess Medical Center, Boston, MA, USA., Rodrigues SL; Beth Israel Deaconess Medical Center, Boston, MA, USA., LaPiana A; Beth Israel Deaconess Medical Center, Boston, MA, USA., Patio RC; Beth Israel Deaconess Medical Center, Boston, MA, USA., Anand T; Beth Israel Deaconess Medical Center, Boston, MA, USA., Fisher J; Beth Israel Deaconess Medical Center, Boston, MA, USA., Mazurek CR; Beth Israel Deaconess Medical Center, Boston, MA, USA., Guan R; Beth Israel Deaconess Medical Center, Boston, MA, USA., Wagh K; Los Alamos National Laboratories, Santa Fe, NM, USA., Theiler J; Los Alamos National Laboratories, Santa Fe, NM, USA., Korber BT; Los Alamos National Laboratories, Santa Fe, NM, USA., Barouch DH; Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: dbarouch@bidmc.harvard.edu.

Publikováno v: Vaccine [Vaccine] 2023 Nov 13; Vol. 41 (47), pp. 6904-6909. Date of Electronic Publication: 2023 Oct 21.

Trivalent mosaic or consensus HIV immunogens prime humoral and broader cellular immune responses in adults.

Autor: Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Fiore-Gartland A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Walsh SR; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Yusim K; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, and New Mexico Consortium, Los Alamos, New Mexico, USA., Frahm N; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Global Health, University of Washington, Seattle, Washington, USA., Elizaga ML; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Maenza J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Scott H; San Francisco Department of Public Health, San Francisco, California, USA., Mayer KH; Harvard Medical School, Boston, Massachusetts, USA.; The Fenway Institute, Fenway Health, Boston, Massachusetts, USA., Goepfert PA; University of Alabama at Birmingham, Birmingham, Alabama, USA., Edupuganti S; Emory University, Atlanta, Georgia, USA., Pantaleo G; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Hutter J; Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA., Morris DE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., De Rosa SC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Geraghty DE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Robb ML; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Michael NL; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Fischer W; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, and New Mexico Consortium, Los Alamos, New Mexico, USA., Giorgi EE; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, and New Mexico Consortium, Los Alamos, New Mexico, USA., Malhi H; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Pensiero MN; Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA., Ferrari G; Duke Human Vaccine Institute and.; Department of Surgery, Duke University, Durham, North Carolina, USA., Tomaras GD; Duke Human Vaccine Institute and.; Department of Surgery, Duke University, Durham, North Carolina, USA., Montefiori DC; Duke Human Vaccine Institute and.; Department of Surgery, Duke University, Durham, North Carolina, USA., Gilbert PB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Haynes BF; Duke Human Vaccine Institute and., Korber BT; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, and New Mexico Consortium, Los Alamos, New Mexico, USA., Baden LR; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Feb 15; Vol. 133 (4). Date of Electronic Publication: 2023 Feb 15.

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.

Autor: Roark RS; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Li H; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Williams WB; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Chug H; Laboratory of Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Mason RD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Gorman J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Wang S; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Lee FH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Rando J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bonsignori M; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Hwang KK; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Saunders KO; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Departments of Immunology and Surgery, Duke University School of Medicine, Durham, NC 27710, USA., Wiehe K; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Moody MA; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Departments of Pediatrics and Immunology, Duke University School of Medicine, Durham, NC 27710, USA., Hraber PT; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Wagh K; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Giorgi EE; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Russell RM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bibollet-Ruche F; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Liu W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Connell J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Smith AG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., DeVoto J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Murphy AI; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Smith J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ding W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Zhao C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Chohan N; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Okumura M; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Rosario C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ding Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Lindemuth E; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bauer AM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bar KJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ambrozak D; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Chao CW; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Chuang GY; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Geng H; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Louder MK; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Nguyen R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Zhang B; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Lewis MG; Bioqual, Inc., Rockville, MD 20850, USA., Raymond DD; Laboratory of Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Doria-Rose NA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Schramm CA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Douek DC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Kepler TB; Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.; Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA., Kelsoe G; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Departments of Immunology and Surgery, Duke University School of Medicine, Durham, NC 27710, USA., Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Korber BT; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Harrison SC; Laboratory of Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA., Haynes BF; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. shawg@pennmedicine.upenn.edu.

Publikováno v: Science (New York, N.Y.) [Science] 2021 Jan 08; Vol. 371 (6525). Date of Electronic Publication: 2020 Nov 19.

Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail.

Autor: Chakraborty S; Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.; Center for Non-Linear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Berndsen ZT; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center and Collaboration of AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA., Hengartner NW; Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Korber BT; Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center and Collaboration of AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA., Gnanakaran S; Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Publikováno v: IScience [iScience] 2020 Nov 20; Vol. 23 (12), pp. 101836. Date of Electronic Publication: 2020 Nov 20 (Print Publication: 2020).

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.

Autor: LaBranche CC; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America., Henderson R; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America., Hsu A; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, United States of America., Behrens S; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America., Chen X; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Zhou T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Wiehe K; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.; Department of Medicine, Duke University Medical Center, Durham, NC, United States of America., Saunders KO; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America.; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America., Alam SM; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.; Department of Medicine, Duke University Medical Center, Durham, NC, United States of America., Bonsignori M; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.; Department of Medicine, Duke University Medical Center, Durham, NC, United States of America., Borgnia MJ; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, United States of America., Sattentau QJ; The Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom., Eaton A; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America., Greene K; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America., Gao H; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America., Liao HX; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.; Department of Medicine, Duke University Medical Center, Durham, NC, United States of America., Williams WB; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.; Department of Medicine, Duke University Medical Center, Durham, NC, United States of America., Peacock J; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.; Department of Medicine, Duke University Medical Center, Durham, NC, United States of America., Tang H; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America., Perez LG; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America., Edwards RJ; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.; Department of Medicine, Duke University Medical Center, Durham, NC, United States of America., Kepler TB; Department of Microbiology, Boston University School of Medicine, Boston, MA, United States of America., Korber BT; Los Alamos National Laboratory, Theoretical Biology & Biophysics, Los Alamos, NM, United States of America., Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America., Acharya P; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America.; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America., Haynes BF; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.; Department of Medicine, Duke University Medical Center, Durham, NC, United States of America., Montefiori DC; Department of Surgery, Duke University Medical Center, Durham, NC, United States of America.; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2019 Sep 17; Vol. 15 (9), pp. e1008026. Date of Electronic Publication: 2019 Sep 17 (Print Publication: 2019).