Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain

Autor: Salwa El-Tawil, Kimmo Jokivarsi, Bryony L. McGarry, Philip Clatworthy, Jennifer Elliot, Michael J. Knight, Robin A. Damion, Keith W. Muir, Risto A. Kauppinen, George Harston, Peter Jezzard, Rose Bosnell, Olli Gröhn, James Kennedy, Davide Carone

Publikováno v: Knight, M, Damion, R, McGarry, B, Bosnell, R, Jokivarsi, K T, Grohn, O H J, Jezzard, P, Harston, G W J, Carone, D, Kennedy, J, El-Tawil, S, Elliot, J, Muir, K W, Clatworthy, P & Kauppinen, R 2019, ' Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain ', Biomedical Spectroscopy and Imaging, vol. 8, no. 1-2, pp. 1-18 . https://doi.org/10.3233/BSI-190185

Background and objective:In hyperacute ischaemic stroke, T2 of cerebral water increases with time. Quantifying this change may be informative of the extent of tissue damage and onset time. Our objective was to develop a user-unbiased method to measur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae3507da3da82c2c3347655d0387764
https://doi.org/10.3233/bsi-190185

Quantifying T

Autor: Robin A, Damion, Michael J, Knight, Bryony L, McGarry, Rose, Bosnell, Peter, Jezzard, George Wj, Harston, Davide, Carone, James, Kennedy, Salwa, El-Tawil, Jennifer, Elliot, Keith W, Muir, Philip, Clatworthy, Risto A, Kauppinen

Publikováno v: Physics in medicine and biology. 64(9)

Apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia highlighting a lesion in acute stroke patients. The MRI T(2) relaxation time changes in ischaemic brain such that T(2) in ADC lesions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8dff11781870bbe0f2a35eb4e794d7b1
https://pubmed.ncbi.nlm.nih.gov/30921782

A Comparison of T2 Relaxation-Based MRI Stroke Timing Methods in Hyperacute Ischemic Stroke Patients: A Pilot Study

Autor: Risto A. Kauppinen, Davide Carone, Bryony L. McGarry, Amith Sitaram, Keith W. Muir, Michael J. Knight, Peter Jezzard, Philip Clatworthy, George Wj Harston, Isabel Chew, Robin A. Damion

Publikováno v: Journal of Central Nervous System Disease. 12:117957352094331

Background: T2 relaxation-based magnetic resonance imaging (MRI) signals may provide onset time for acute ischemic strokes with an unknown onset. The ability of visual and quantitative MRI-based methods in a cohort of hyperacute ischemic stroke patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86e8be40b3c746c99c5aa24d889560a5
https://doi.org/10.1177/1179573520943314

Stroke onset time estimation from multispectral quantitative magnetic resonance imaging in a rat model of focal permanent cerebral ischaemia

Autor: Bryony L. McGarry, Alejandra Sierra, Risto A. Kauppinen, Michael J. Knight, Kimmo Jokivarsi, Olli Gröhn, Harriet J Rogers

Publikováno v: McGarry, B, Rogers, H, Knight, M J, Jokivarsi, K T, Sierra, A, Grohn, O H J & Kauppinen, R A 2016, ' Stroke onset time estimation from multispectral quantitative magnetic resonance imaging in a rat model of focal permanent cerebral ischaemia ', International Journal of Stroke, vol. 11, no. 6, pp. 677-682 . https://doi.org/10.1177/1747493016641124

Background Quantitative T2 relaxation magnetic resonance imaging allows estimation of stroke onset time. Aims We aimed to examine the accuracy of quantitative T1 and quantitative T2 relaxation times alone and in combination to provide estimates of st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a163a6da2a101948521d5ae3257d7f
https://research-information.bris.ac.uk/ws/files/61782615/IJS_10_15_4497_REVISED.pdf

Timing the ischaemic stroke by 1H-MRI: improved accuracy using absolute relaxation times over signal intensities

Autor: Harriet J Rogers, Olli Gröhn, Bryony L. McGarry, Risto A. Kauppinen, Michael J. Knight, Kimmo Jokivarsi

Publikováno v: Neuroreport. 25(15)

One in four ischaemic stroke patients are ineligible for thrombolytic treatment due to unknown onset time. Quantification of absolute MR relaxation times and signal intensities are potential methods for estimating stroke duration. We compared the acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63366090683400c71d12f4252fc5122
https://pubmed.ncbi.nlm.nih.gov/25116145