IL-7R signaling activates widespread VH and DH gene usage to drive antibody diversity in bone marrow B cells

Autor: Amanda Baizan-Edge, Bryony A. Stubbs, Michael J.T. Stubbington, Daniel J. Bolland, Kristina Tabbada, Simon Andrews, Anne E. Corcoran

Publikováno v: Cell Reports, Vol 36, Iss 2, Pp 109349- (2021)

Summary: Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. The role of interleukin-7 receptor (IL-7R) signaling in Igh recombination has been difficu

Externí odkaz: https://doaj.org/article/caa7942b52f54fda8e0d94ca19d1c1da

IL-7R signaling activates widespread V

Autor: Amanda, Baizan-Edge, Bryony A, Stubbs, Michael J T, Stubbington, Daniel J, Bolland, Kristina, Tabbada, Simon, Andrews, Anne E, Corcoran

Publikováno v: Cell Reports

Summary Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. The role of interleukin-7 receptor (IL-7R) signaling in Igh recombination has been difficul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c96df32c9acda207a41786517de07f0c
https://pubmed.ncbi.nlm.nih.gov/34260907

IL-7R Signalling Activates Widespread V H and D H Gene Usage to Drive Antibody Diversity in Bone Marrow B Cells

Autor: Kristina Tabbada, Amanda Baizan-Edge, Simon Andrews, Daniel J. Bolland, Michael J. T. Stubbington, Anne E. Corcoran, Bryony A. Stubbs

Publikováno v: SSRN Electronic Journal.

Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. It has been proposed that interleukin-7 receptor (IL-7R) signalling is necessary for Igh recombinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6aaf56b490bb7034322c19377c0b1008
https://doi.org/10.2139/ssrn.3751673

NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate

Autor: Dominika A. Dudzinska, Christine Helliwell, Brian Hendrich, Manel Esteller, María Berdasco, Bryony A. Stubbs, Paulina A. Latos, Olukunbi Mosaku

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Biology Open
Dipòsit Digital de la UB
Universidad de Barcelona
Biology Open, Vol 1, Iss 4, Pp 341-352 (2012)

Embryonic Stem (ES) cells are able to give rise to the three germ layers of the embryo but are prevented from contributing to the trophoblast. The molecular nature of this barrier between embryonic and trophectodermal cell fates is not clear, but is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60c378725c4308c347da6ab09b775bf
https://doi.org/10.1242/bio.2012513