Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bryon Simmons"'
Autor:
Stephen M. Dalby, Louis-Charles Campeau, Bryon Simmons, Tyler A. Davis, Amude M. Kassim, Timothy J. Wright, Ralph Calabria, Zhiguo J. Song, Cyndi Qixin He, John Limanto, John Y. L. Chung
Publikováno v:
Organic Process Research & Development. 26:698-709
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acaf361c14adf7ecc1b65e7423f440f6
https://doi.org/10.1021/acs.oprd.1c00175
https://doi.org/10.1021/acs.oprd.1c00175
Autor:
Kevin R. Campos, Lushi Tan, Daniel A. DiRocco, Tyler A. Davis, Rebecca T. Ruck, Peter E. Maligres, Artis Klapars, John Y. L. Chung, Zhiguo Jake Song, Mona Utne Larsen, Wenyong Chen, Timothy J. Wright, Amude M. Kassim, Guiquan Liu, John Limanto, Aaron Moment, Stephen M. Dalby, Susan L. Zultanski, Louis-Charles Campeau, Ralph Calabria, Michael Shevlin, Feng Peng, Bryon Simmons, Alan M. Hyde
Publikováno v:
Chemical Science
An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis was achieved by development of several synthetic methods: (1) complexation-driven selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619837ac9c9305f72e68520fc73a7a54
https://pubmed.ncbi.nlm.nih.gov/34276931
https://pubmed.ncbi.nlm.nih.gov/34276931
Autor:
Robert K. Orr, Jamie M. McCabe Dunn, Edward C. Sherer, Rebecca T. Ruck, Mikhail Reibarkh, Ana Bellomo, Bryon Simmons
Publikováno v:
Chemical Science
The direct and chemoselective 3′-phosphoramidation, phosphorylation and acylation of nucleosides are described.
The direct and chemoselective 3′-phosphoramidation, phosphorylation and acylation of nucleosides are described. Upon the discover
The direct and chemoselective 3′-phosphoramidation, phosphorylation and acylation of nucleosides are described. Upon the discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7565f11ce777ec5135cde9043240d1e
https://doi.org/10.1039/c6sc05081f
https://doi.org/10.1039/c6sc05081f
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 125:110-113
A gasometric titration method was developed to quantitate active alkylaluminum content in dimethylaluminum chloride solution to perform the stoichiometry calculation for the reaction charge. The procedure was reproducible with good precision, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d7d6e33305f80ccf49ac6ca1bdccc9
https://doi.org/10.1016/j.jpba.2016.03.022
https://doi.org/10.1016/j.jpba.2016.03.022
Autor:
Jaume Balsells, Edward J. J. Grabowski, Shane W. Krska, Nelo R. Rivera, Yongkui Sun, Joseph D. Armstrong, Bryon Simmons, Andrew M. Clausen, Felix Spindler, Yi Hsiao, Michele Kubryk, Christophe Malan, Karl B. Hansen, Nori Ikemoto, Feng Xu, Thorsten Rosner
Publikováno v:
Journal of the American Chemical Society. 142:13622-13622
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff28a025888c0453761a46c2fa910f8b
https://doi.org/10.1021/jacs.0c06041
https://doi.org/10.1021/jacs.0c06041
Publikováno v:
Organic letters. 19(9)
A general and efficient method for the synthesis of pronucleotide (ProTide) 5'-phosphoramidate monoesters is reported. This method consists of a highly stereoselective 5'-phosphorylation mediated by dimethylaluminum chloride to afford the desired tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6af197adcb55bed1fadb8c6e80ac75c
https://pubmed.ncbi.nlm.nih.gov/28418681
https://pubmed.ncbi.nlm.nih.gov/28418681
Publikováno v:
Angewandte Chemie. 121:4413-4417
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14ffc5e343c014f006681088dc017326
https://doi.org/10.1002/ange.200900220
https://doi.org/10.1002/ange.200900220
Publikováno v:
Tetrahedron. 65:3232-3238
A range of N,N-dialkylanilines have been successfully converted to the parent substituted benzenes by a novel two-step pathway. The products are obtained in good yields and optical purity of adjacent stereocenters is maintained. This technology has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f413db8afc260d0e9c2bdd771f5351e6
https://doi.org/10.1016/j.tet.2008.12.054
https://doi.org/10.1016/j.tet.2008.12.054
Autor:
Sandor Karady, Jerry A. Murry, Kenneth J. Fitch, David M. Tschaen, Feng Xu, Edward G. Corley, Bryon Simmons
Publikováno v:
Organic Letters. 8:3885-3888
[reaction: see text] An expedient, atom-economical, asymmetric synthesis of 1-aryl-3-azabicyclo[3.1.0]hexanes, including (+)-Bicifadine and DOV21947, in a single-stage through process without isolation of any intermediates has been developed. The key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b7f31fd84af10a807ad7ba3e39ecd6
https://doi.org/10.1021/ol061650w
https://doi.org/10.1021/ol061650w
Autor:
George Zhou, Edward J. J. Grabowski, Feng Xu, Bryon Simmons, Zhihong Ge, David Hughes, Joseph D. Armstrong
Publikováno v:
Journal of the American Chemical Society. 126:13002-13009
A practical, one-pot process for the preparation of beta-keto amides via a three-component reaction, including Meldrum's acid, an amine, and a carboxylic acid, has been developed. Key to development of an efficient, high-yielding process was an in-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1870491fae974c6a98880dada54a1f63
https://doi.org/10.1021/ja046488b
https://doi.org/10.1021/ja046488b