Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bryon S. Drown"'
Autor:
Ananya Anmangandla, Sadhan Jana, Kewen Peng, Shamar D. Wallace, Saket R. Bagde, Bryon S. Drown, Jiashu Xu, Paul J. Hergenrother, J. Christopher Fromme, Hening Lin
Publikováno v:
ACS Chemical Biology. 18:1200-1207
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::605a99898cfece68015b011bcaea49c1
https://doi.org/10.1021/acschembio.3c00092
https://doi.org/10.1021/acschembio.3c00092
Autor:
Teagan L. Campbell, Bryon S. Drown
Publikováno v:
Nature Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9662609105fd6956a542e5089962e1f
https://doi.org/10.1038/s41589-023-01285-7
https://doi.org/10.1038/s41589-023-01285-7
Autor:
Pei Su, John P. McGee, Kenneth R. Durbin, Michael A. R. Hollas, Manxi Yang, Elizabeth K. Neumann, Jamie L. Allen, Bryon S. Drown, Fatma Ayaloglu Butun, Joseph B. Greer, Bryan P. Early, Ryan T. Fellers, Jeffrey M. Spraggins, Julia Laskin, Jeannie M. Camarillo, Jared O. Kafader, Neil L. Kelleher
Publikováno v:
Science advances. 8(32)
Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS), which increases the size limit for proteoform detection and identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b4e257e35227291c9bd87d3f9a773c
https://pubmed.ncbi.nlm.nih.gov/35947651
https://pubmed.ncbi.nlm.nih.gov/35947651
Autor:
Lauren M. Adams, Caroline J. DeHart, Bryon S. Drown, Lissa C. Anderson, William Bocik, Emily S. Boja, Tara M. Hiltke, Christopher L. Hendrickson, Henry Rodriguez, Michael Caldwell, Reza Vafabakhsh, Neil L. Kelleher
Publikováno v:
The Journal of biological chemistry. 299(1)
The KRAS gene is one of the most frequently mutated oncogenes in human cancer and gives rise to two isoforms, KRAS4A and KRAS4B. KRAS post-translational modifications (PTMs) have the potential to influence downstream signaling. However, the relations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7083ab8b0cc92583f0e0a81a43bf552
https://pubmed.ncbi.nlm.nih.gov/36470426
https://pubmed.ncbi.nlm.nih.gov/36470426
Autor:
Bryon S. Drown, Kevin Jooß, Rafael D. Melani, Cameron Lloyd-Jones, Jeannie M. Camarillo, Neil L. Kelleher
Publikováno v:
Journal of proteome research. 21(5)
A functional understanding of the human body requires structure-function studies of proteins at scale. The chemical structure of proteins is controlled at the transcriptional, translational, and post-translational levels, creating a variety of produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e130c1f66d68051037cb49f52358226
https://pubmed.ncbi.nlm.nih.gov/35413190
https://pubmed.ncbi.nlm.nih.gov/35413190
Autor:
Lee Myung-Ryul, Bryon S. Drown, Stephen E. Motika, Paul J. Hergenrother, Sarah J Perlmutter, Emily J. Geddes
Publikováno v:
ACS Infect Dis
Multidrug-resistant Gram-negative bacterial infections are on the rise, and with no FDA approvals for new classes of broad-spectrum antibiotics in over 50 years, these infections constitute a major threat to human health. A significant challenge is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfa69088c479632e3d74cf41a993cda
https://doi.org/10.1021/acsinfecdis.0c00715
https://doi.org/10.1021/acsinfecdis.0c00715
Autor:
Pei Su, John P. McGee, Kenneth R. Durbin, Michael A. R. Hollas, Manxi Yang, Elizabeth K. Neumann, Jamie L. Allen, Bryon S. Drown, Fatma Ayaloglu Butun, Joseph B. Greer, Bryan P. Early, Ryan T. Fellers, Jeffrey M. Spraggins, Julia Laskin, Jeannie M. Camarillo, Jared O. Kafader, Neil L. Kelleher
Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS), which increases the size limit for proteoform detection and identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84625188e5d50a57e1c1d677c03a9789
https://doi.org/10.1101/2021.12.07.471638
https://doi.org/10.1101/2021.12.07.471638
Autor:
Nahed Ismail, Erica N. Parker, Bryon S. Drown, Hyang Yeon Lee, Emily J. Geddes, Gee W. Lau, Paul J. Hergenrother
Publikováno v:
Nature microbiology
Gram-negative bacterial infections are a significant public health concern, and the lack of new drug classes for these pathogens is linked to the inability of most drug leads to accumulate inside Gram-negative bacteria1-7. Here we report the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d189cd02baf7284537782164c3b7a7
http://europepmc.org/articles/PMC6953607
http://europepmc.org/articles/PMC6953607
Autor:
Alfredo Garcia, Bryon S. Drown, Tomohiro Shirai, Michelle F. Richter, Riley L. Svec, Paul J. Hergenrother, Andrew P. Riley
Publikováno v:
Nature. 545:299-304
Most small molecules are unable to rapidly traverse the outer membrane of Gram-negative bacteria and accumulate inside these cells, making the discovery of much-needed drugs against these pathogens challenging. Current understanding of the physicoche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37d5dcc6b562f0114d6b281ee2abd7b
https://doi.org/10.1038/nature22308
https://doi.org/10.1038/nature22308
Autor:
Paul J. Hergenrother, Bryon S. Drown
Publikováno v:
Proceedings of the National Academy of Sciences. 115:6530-6532
Bacterial infections resistant to antibiotics are becoming more common, posing a significant health risk (1). The CDC and WHO have identified gram-negative drug-resistant pathogens as being particularly dangerous, and such infections are resistant to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a719fde99b03db00f32c44266a4853bd
https://doi.org/10.1073/pnas.1807278115
https://doi.org/10.1073/pnas.1807278115