Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Bryndis Birnir"'
Autor:
Zhe Jin, Hayma Hammoud, Amol Keshavasa Bhandage, Sergiy Vasylyovych Korol, Olivia Trujeque-Ramos, Stasini Koreli, Zhitao Gong, Azasul Islam Chowdhury, Friederike Andrea Sandbaumhüter, Erik Tomas Jansson, Robin Sean Lindsay, Gustaf Christoffersson, Per Erik Andrén, Per-Ola Carlsson, Peter Bergsten, Masood Kamali-Moghaddam, Bryndis Birnir
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105217- (2024)
Summary: Background: γ-aminobutyric acid (GABA), known as the main inhibitory neurotransmitter in the brain, exerts immunomodulatory functions by interaction with immune cells, including T cells. Metabolic programs of T cells are closely linked to t
Externí odkaz:
https://doaj.org/article/fb8964c5e13b45b2a6723e83c99f1a33
Autor:
Jens Schuster, Joakim Klar, Ayda Khalfallah, Loora Laan, Jan Hoeber, Ambrin Fatima, Velin Marita Sequeira, Zhe Jin, Sergiy V. Korol, Mikael Huss, Ann Nordgren, Britt Marie Anderlid, Caroline Gallant, Bryndis Birnir, Niklas Dahl
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Mowat-Wilson syndrome (MWS) is a severe neurodevelopmental disorder caused by heterozygous variants in the gene encoding transcription factor ZEB2. Affected individuals present with structural brain abnormalities, speech delay and epilepsy. In mice,
Externí odkaz:
https://doaj.org/article/3367a1ecb0fa455a9d3e6d6550ba3e2c
Autor:
Daniel Espes, Per-Ola Carlsson, Hanna Liljebäck, Henrik Hill, Andris Elksnis, José Caballero-Corbalan, Bryndis Birnir
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
Introduction Experimentally, gamma-aminobutyric acid (GABA) has been found to exert immune-modulatory effects and induce beta-cell regeneration, which make it a highly interesting substance candidate for the treatment of type 1 diabetes (T1D). In man
Externí odkaz:
https://doaj.org/article/925b895b389e4c4cb5e3ec098858f9be
Autor:
Henrik Hill, Andris Elksnis, Per Lundkvist, Kumari Ubhayasekera, Jonas Bergquist, Bryndis Birnir, Per-Ola Carlsson, Daniel Espes
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 91 (2021)
Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the central nervous system (CNS) and outside of the CNS, found in the highest concentrations in immune cells and pancreatic beta-cells. GABA is gaining increasing interest
Externí odkaz:
https://doaj.org/article/7623d43e37e248ffa239e06a46b71a94
Autor:
Jens Schuster, Loora Laan, Joakim Klar, Zhe Jin, Mikael Huss, Sergiy Korol, Feria Hikmet Noraddin, Maria Sobol, Bryndis Birnir, Niklas Dahl
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Dravet syndrome (DS) is an early onset refractory epilepsy typically caused by de novo heterozygous variants in SCN1A encoding the α-subunit of the neuronal sodium channel Nav1.1. The syndrome is characterized by age-related progression of seizures,
Externí odkaz:
https://doaj.org/article/e1025a1b1221479ead021722ed01dc8d
Autor:
Malin Kvarnung, Mansoureh Shahsavani, Fulya Taylan, Mohsen Moslem, Nicole Breeuwsma, Loora Laan, Jens Schuster, Zhe Jin, Daniel Nilsson, Agne Lieden, Britt-Marie Anderlid, Magnus Nordenskjöld, Elisabeth Syk Lundberg, Bryndis Birnir, Niklas Dahl, Ann Nordgren, Anna Lindstrand, Anna Falk
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
The etiology of hereditary ataxia syndromes is heterogeneous, and the mechanisms underlying these disorders are often unknown. Here, we utilized exome sequencing in two siblings with progressive ataxia and muscular weakness and identified a novel hom
Externí odkaz:
https://doaj.org/article/eb1ae168167442b19cc7e473c85356fe
Autor:
Sergiy V. Korol, Zhe Jin, Yang Jin, Amol K. Bhandage, Anders Tengholm, Nikhil R. Gandasi, Sebastian Barg, Daniel Espes, Per-Ola Carlsson, Derek Laver, Bryndis Birnir
Publikováno v:
EBioMedicine, Vol 30, Iss , Pp 273-282 (2018)
In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human is
Externí odkaz:
https://doaj.org/article/1bc71a74c5a548beb4885579c8991456
Autor:
Amol K. Bhandage, Zhe Jin, Sergiy V. Korol, Qiujin Shen, Yu Pei, Qiaolin Deng, Daniel Espes, Per-Ola Carlsson, Masood Kamali-Moghaddam, Bryndis Birnir
Publikováno v:
EBioMedicine, Vol 30, Iss , Pp 283-294 (2018)
The neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule in the brain and in pancreatic islets. Here, we demonstrate that GABA regulates cytokine secretion from human peripheral blood mononuclear cells (PBMCs) and CD4+
Externí odkaz:
https://doaj.org/article/5233afe6baa547a89af25ec1e6f92be3
Publikováno v:
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-7 (2017)
Abstract Background γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain where it regulates activity of neuronal networks. The receptor for glucagon-like peptide-1 (GLP-1) is expressed in the hippocampus, which is the cent
Externí odkaz:
https://doaj.org/article/960878ffdc5f476782fcb04e20e08004
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 600 (2020)
In pancreatic islets, the major cell-types are α, β and δ cells. The γ-aminobutyric acid (GABA) signalling system is expressed in human pancreatic islets. In single hormone transcript-expressing cells, we have previously characterized the functio
Externí odkaz:
https://doaj.org/article/190b41e6ec104abda86319d74edcb0ac