Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Bryn M. Owen"'
Autor:
Tatiana Lopes, David CD. Hope, Jose M. Ramos-Pittol, Anna Curtis, Jed V. Shrewsbury, Iona Davies, Zijing Zhou, Alessandro Sardini, James S. Minnion, Dirk Dormann, Gavin A. Bewick, Kevin G. Murphy, David Carling, Stephen R. Bloom, Tricia MM. Tan, Bryn M. Owen
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102024- (2024)
Objective: Glucagon has long been proposed as a component of multi-agonist obesity therapeutics due to its ability to induce energy expenditure and cause weight loss. However, chronic glucagon-receptor agonism has been associated with a reduction in
Externí odkaz:
https://doaj.org/article/d0ac3e309a1b4c52b8fc5d7efd834e06
Autor:
Jose M. Ramos-Pittol, Isabel Fernandes-Freitas, Alexandra Milona, Stephen M. Manchishi, Kara Rainbow, Brian Y. H. Lam, John A. Tadross, Anthony Beucher, William H. Colledge, Inês Cebola, Kevin G. Murphy, Irene Miguel-Aliaga, Giles S. H. Yeo, Waljit S. Dhillo, Bryn M. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exe
Externí odkaz:
https://doaj.org/article/59195b68a82445d591a6b19294b35586
Autor:
Charlotte E. Hinds, Bryn M. Owen, David C. D. Hope, Philip Pickford, Ben Jones, Tricia M. Tan, James S. Minnion, Stephen R. Bloom
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Glucagon receptor agonists show promise as components of next generation metabolic syndrome pharmacotherapies. However, the biology of glucagon action is complex, controversial, and likely context dependent. As such, a better understanding o
Externí odkaz:
https://doaj.org/article/8c5c2844790d4fd68305731ce059ecb1
Autor:
Alexandra Milona, Vittoria Massafra, Harmjan Vos, Jyoti Naik, Natalia Artigas, Helen A.B. Paterson, Ingrid T.G.W. Bijsmans, Ellen C.L. Willemsen, Jose M. Ramos Pittol, Irene Miguel-Aliaga, Piter Bosma, Boudewijn M.T. Burgering, Catherine Williamson, Santiago Vernia, Waljit S. Dhillo, Saskia W.C. van Mil, Bryn M. Owen
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 221-229 (2019)
Objective: Coupling metabolic and reproductive pathways is essential for the survival of species. However, the functions of steroidogenic enzymes expressed in metabolic tissues are largely unknown. Methods and results: Here, we show that in the liver
Externí odkaz:
https://doaj.org/article/f03fe7de90804886b4db2443d1f7e1c8
Autor:
Phil Pickford, Maria Lucey, Roxana-Maria Rujan, Emma Rose McGlone, Stavroula Bitsi, Fiona B. Ashford, Ivan R. Corrêa, David J. Hodson, Alejandra Tomas, Giuseppe Deganutti, Christopher A. Reynolds, Bryn M. Owen, Tricia M. Tan, James Minnion, Ben Jones, Stephen R. Bloom
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101242- (2021)
Objective: Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating t
Externí odkaz:
https://doaj.org/article/81eb48b9c1554fad855b7b0e36385ffc
Autor:
Ben Jones, Teresa Buenaventura, Nisha Kanda, Pauline Chabosseau, Bryn M. Owen, Rebecca Scott, Robert Goldin, Napat Angkathunyakul, Ivan R. Corrêa Jr, Domenico Bosco, Paul R. Johnson, Lorenzo Piemonti, Piero Marchetti, A. M. James Shapiro, Blake J. Cochran, Aylin C. Hanyaloglu, Asuka Inoue, Tricia Tan, Guy A. Rutter, Alejandra Tomas, Stephen R. Bloom
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Glucagon-like peptide-1 receptor (GLP-1R) promotes insulin secretion from pancreatic beta cells and undergoes agonist-mediated endocytosis. Here, authors study GLP-1R endocytosis caused by different agonists and show that a longer plasma membrane ret
Externí odkaz:
https://doaj.org/article/1a1126743c294faca93a0169f9e7cb17
Autor:
Alex Montoya, Emirhan Tasoez, Holger Kramer, Olof Idevall-Hagren, S Neda Mousavy Gharavy, Steven Millership, Mark Ibberson, Ming Hu, Aida Martinez-Sanchez, Paul Gadue, Eleni Georgiadou, Isabelle Leclerc, Dominic J. Withers, Nikolay Ninov, Bryn M. Owen, Pauline Chabosseau, Grazia Pizza, David A. Jacobson, Matthew T. Dickerson, Fabian L. Cardenas-Diaz, Zenobia B. Mehta, Marianne Voz, Christophe Magnan, Céline Cruciani-Guglielmacci, Nicholas H. F. Fine, Guy A. Rutter
Publikováno v:
Diabetologia
Diabetologia, 2021, 64 (4), pp.850-864. ⟨10.1007/s00125-020-05350-x⟩
Diabetologia, 2021, 64 (4), pp.850-864. ⟨10.1007/s00125-020-05350-x⟩
Aims/hypothesis Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in disease development,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3515d1e5f62db8cf8036e2aa24a6876b
http://europepmc.org/articles/PMC7829492
http://europepmc.org/articles/PMC7829492
The effect of exogenous kisspeptin administration in a novel mouse model of hypothalamic amenorrhoea
Autor:
Maria Phylactou, Kah-Yan Ng, Ali Abbara, Kevin T. O'Byrne, Caitlin McIntyre, Waljit S. Dhillo, Jed V Shrewsbury, Bryn M. Owen, Xiao Feng Li
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39d4fb577cfa29c84a66d0cb43a22882
https://doi.org/10.1530/endoabs.77.p243
https://doi.org/10.1530/endoabs.77.p243
Autor:
Phyllis Phuah, Sijing Cheng, Frank Reimann, Anna Roberts, Aylin C. Hanyaloglu, Emile Otsubo, Mariana Norton, Bryn M. Owen, Fiona M. Gribble, Kevin Murphy
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feb26dfd3494d46b66c2a8a9dc03c6f7
https://doi.org/10.1530/endoabs.77.oc3.5
https://doi.org/10.1530/endoabs.77.oc3.5
Autor:
Ali Abbara, Alexander N Comninos, Victoria C. Wing, Bryn M. Owen, Lysia Demetriou, Layla Thurston, Edouard Mills, Eugenii A. Rabiner, Lisa Yang, Waljit S. Dhillo, James O’Callaghan, Matthew B. Wall
Publikováno v:
Psychoneuroendocrinology
Gamma-aminobutyric acid (GABA) is a key inhibitory neurotransmitter that has been implicated in the aetiology of common mood and behavioural disorders. By employing proton magnetic resonance spectroscopy in man, we demonstrate that administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136f17ac5e213e850359755fc0f9eb08
http://hdl.handle.net/10044/1/89399
http://hdl.handle.net/10044/1/89399
