Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Bryn A. Martin"'
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Background Achieving effective drug delivery to the central nervous system (CNS) remains a challenge for treating neurological disorders. Intrathecal (IT) delivery, which involves direct injection into the cerebrospinal fluid (CSF), presents
Externí odkaz:
https://doaj.org/article/948e62293a1542d4acb79495b0302fd9
Autor:
Mohammadreza Khani, Goutham Kumar Reddy Burla, Lucas R. Sass, Ostin N. Arters, Tao Xing, Haiming Wu, Bryn A. Martin
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Background Intrathecal drug delivery has a significant role in pain management and central nervous system (CNS) disease therapeutics. A fluid-physics based tool to assist clinicians in choosing specific drug doses to the spine or brain may h
Externí odkaz:
https://doaj.org/article/1a39812d5482420ebed02d1d88cd02e2
Autor:
Gwendolyn Williams, Suraj Thyagaraj, Audrey Fu, John Oshinski, Daniel Giese, Alexander C. Bunck, Eleonora Fornari, Francesco Santini, Mark Luciano, Francis Loth, Bryn A. Martin
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Phase contrast magnetic resonance imaging, PC MRI, is a valuable tool allowing for non-invasive quantification of CSF dynamics, but has lacked adoption in clinical practice for Chiari malformation diagnostics. To improve these dia
Externí odkaz:
https://doaj.org/article/f0e39c5984234016950962b51c637017
Autor:
Gabryel Conley Natividad, Sophia K. Theodossiou, Nathan R. Schiele, Gordon K. Murdoch, Alkiviadis Tsamis, Bertrand Tanner, Gabriel Potirniche, Martin Mortazavi, David A. Vorp, Bryn A. Martin
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background The pia arachnoid complex (PAC) is a cerebrospinal fluid-filled tissue conglomerate that surrounds the brain and spinal cord. Pia mater adheres directly to the surface of the brain while the arachnoid mater adheres to the deep sur
Externí odkaz:
https://doaj.org/article/322114f2c13f42059ebec84496c38a98
Autor:
Mohammadreza Khani, Lucas R. Sass, M. Keith Sharp, Aaron R. McCabe, Laura M. Zitella Verbick, Shivanand P. Lad, Bryn A. Martin
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Blood removal from cerebrospinal fluid (CSF) in post-subarachnoid hemorrhage patients may reduce the risk of related secondary brain injury. We formulated a computational fluid dynamics (CFD) model to investigate the impact of a d
Externí odkaz:
https://doaj.org/article/9818cf6ab2e142139f43ce552561e0ec
Autor:
Lucas R. Sass, Mohammadreza Khani, Jacob Romm, Marianne Schmid Daners, Kyle McCain, Tavara Freeman, Gregory T. Carter, Douglas L. Weeks, Brian Petersen, Jason Aldred, Dena Wingett, Bryn A. Martin
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-14 (2020)
Abstract Background Developing novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due to close proximity of
Externí odkaz:
https://doaj.org/article/9ffaef86f36b40f69fdb3c8159dc0537
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-17 (2019)
Abstract Background As an alternative to advection, solute transport by shear-augmented dispersion within oscillatory cerebrospinal fluid flow was investigated in small channels representing the basement membranes located between cerebral arterial sm
Externí odkaz:
https://doaj.org/article/a01c36d97157429ea754c07db3c59576
Autor:
Braden J. Lawrence, Aintzane Urbizu, Philip A. Allen, Francis Loth, R. Shane Tubbs, Alexander C. Bunck, Jan-Robert Kröger, Brandon G. Rocque, Casey Madura, Jason A. Chen, Mark G. Luciano, Richard G. Ellenbogen, John N. Oshinski, Bermans J. Iskandar, Bryn A. Martin
Publikováno v:
Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background Type 1 Chiari malformation (CM-I) has been historically defined by cerebellar tonsillar position (TP) greater than 3–5 mm below the foramen magnum (FM). Often, the radiographic findings are highly variable, which may influence t
Externí odkaz:
https://doaj.org/article/b60e95cb13414bcdaf2b5d9e3d3f1b5c
Autor:
Lucas R. Sass, Mohammadreza Khani, Gabryel Connely Natividad, R. Shane Tubbs, Olivier Baledent, Bryn A. Martin
Publikováno v:
Fluids and Barriers of the CNS, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background The spinal subarachnoid space (SSS) has a complex 3D fluid-filled geometry with multiple levels of anatomic complexity, the most salient features being the spinal cord and dorsal and ventral nerve rootlets. An accurate anthropomor
Externí odkaz:
https://doaj.org/article/4c36688b48be458b9e04eee1f9dfe6df
Autor:
Maggie S. Eppelheimer, James R. Houston, Jayapalli R. Bapuraj, Richard Labuda, Dorothy M. Loth, Audrey M. Braun, Natalie J. Allen, Soroush Heidari Pahlavian, Dipankar Biswas, Aintzane Urbizu, Bryn A. Martin, Cormac O. Maher, Philip A. Allen, Francis Loth
Publikováno v:
Frontiers in Neuroanatomy, Vol 12 (2018)
Purpose: Researchers have sought to better understand Chiari type I malformation (CMI) through morphometric measurements beyond tonsillar position (TP). Soft tissue and bone structures within the brain and craniocervical junction have been shown to b
Externí odkaz:
https://doaj.org/article/1b02fa3c3403465194c5f40e613612c7