Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Bryn A. Bridges"'
Autor:
Bryn A. Bridges
Publikováno v:
DNA Repair. 10:801-805
Autor:
David Neil Cooper, Trevor J. McMillan, Yuri E. Dubrova, Eric G. Wright, R. Waters, Simon Bouffler, Bryn A. Bridges, John Thacker
Publikováno v:
Radiation Research. 165:249-268
This review assesses recent data on mutational risk to the germline after radiation exposure obtained by molecular analysis of tandemly repeated DNA loci (TRDLs): minisatellites in humans and expanded simple tandem repeats in mice. Some studies, part
Autor:
Bryn A. Bridges
Publikováno v:
DNA Repair. 4:725-739
Evelyn Witkin hypothesized in 1967 that bacterial cell division is controlled by a repressor which, like the lambda repressor, is inactivated by a complex process that starts with the presence of replication-blocking lesions in the DNA. She further s
Autor:
Bryn A. Bridges
Publikováno v:
DNA Repair. 4:618-634
Dean Rupp and Paul Howard-Flanders showed that, following exposure to ultraviolet light, bacteria deficient in nucleotide excision repair synthesised DNA with minimal delay and in pieces roughly the size of the distances between pyrimidine dimmers. T
Autor:
Bryn A. Bridges
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 509:3-16
Autor:
Errol C. Friedberg, Bryn A. Bridges
Publikováno v:
DNA Repair. 1:169-174
Autor:
Roger Woodgate, Andrew R. Timms, Antonio R. Fernández de Henestrosa, Bryn A. Bridges, Dominique Vandewiele
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 499:85-95
In the 1970s, several thermosensitive alleles of dnaE (encoding the alpha-catalytic subunit of pol III) were isolated. Genetic characterization of these dnaE mutants revealed that some are mutator alleles at permissive temperature. We have determined
Autor:
Bryn A. Bridges, Andrew R. Timms
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 499:97-101
The temperature-sensitive DNA polymerase III (Pol III) encoded by the dnaE486 allele confers a spontaneous mutator activity in SOS-induced bacteria that is largely dependent upon DNA polymerase V (Pol V), encoded by umuD, C. This mutator activity is
Autor:
Bryn A. Bridges
Publikováno v:
Mutation Research/DNA Repair. 485:61-67
The formation of base substitution mutations following exposure of bacteria to ultraviolet light and many other mutagens occurs during translesion synthesis opposite a photoproduct or other lesion in the template strand of DNA. This process requires
Autor:
Bryn A. Bridges
Publikováno v:
BioEssays. 22:933-937
Until recently, it had been concluded from genetic evidence that DNA polymerase III (Pol III, the main replicative polymerase in E. coli) was also responsible for mutagenic translesion synthesis on damaged templates, albeit under the influence of ind