Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Bryn A Martin"'
Autor:
Mohammadreza Khani, Audrey Q Fu, Joshua Pluid, Christina P Gibbs, John N Oshinski, Tao Xing, Gregory R Stewart, Jillynne R Zeller, Bryn A Martin
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244090 (2020)
A detailed understanding of the CSF dynamics is needed for design and optimization of intrathecal drug delivery devices, drugs, and protocols. Preclinical research using large-animal models is important to help define drug pharmacokinetics-pharmacody
Externí odkaz:
https://doaj.org/article/bba280811e634e9b98b606b27ad3b389
Autor:
Mohammadreza Khani, Braden J Lawrence, Lucas R Sass, Christina P Gibbs, Joshua J Pluid, John N Oshinski, Gregory R Stewart, Jillynne R Zeller, Bryn A Martin
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212239 (2019)
Recent advancements have been made toward understanding the diagnostic and therapeutic potential of cerebrospinal fluid (CSF) and related hydrodynamics. Increased understanding of CSF dynamics may lead to improved detection of central nervous system
Externí odkaz:
https://doaj.org/article/13ae97fe63ba48a69fe14fd69f632992
Autor:
Per Thomas Haga, Giulia Pizzichelli, Mikael Mortensen, Miroslav Kuchta, Soroush Heidari Pahlavian, Edoardo Sinibaldi, Bryn A Martin, Kent-Andre Mardal
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173680 (2017)
Intrathecal drug and gene vector delivery is a procedure to release a solute within the cerebrospinal fluid. This procedure is currently used in clinical practice and shows promise for treatment of several central nervous system pathologies. However,
Externí odkaz:
https://doaj.org/article/51ea410f33344f88ad71db479f3f5dda
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Background Achieving effective drug delivery to the central nervous system (CNS) remains a challenge for treating neurological disorders. Intrathecal (IT) delivery, which involves direct injection into the cerebrospinal fluid (CSF), presents
Externí odkaz:
https://doaj.org/article/948e62293a1542d4acb79495b0302fd9
Autor:
Philip A Allen, James R Houston, Joshua W Pollock, Christopher Buzzelli, Xuan Li, A Katherine Harrington, Bryn A Martin, Francis Loth, Mei-Ching Lien, Jahangir Maleki, Mark G Luciano
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94844 (2014)
OBJECTIVE: Our objective was to use episodic memory and executive function tests to determine whether or not Chiari Malformation Type I (CM) patients experience cognitive dysfunction. BACKGROUND: CM is a neurological syndrome in which the cerebellum
Externí odkaz:
https://doaj.org/article/349bafc19363406f9738051a4448414e
Autor:
Soroush Heidari Pahlavian, Theresia Yiallourou, R Shane Tubbs, Alexander C Bunck, Francis Loth, Mark Goodin, Mehrdad Raisee, Bryn A Martin
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e91888 (2014)
Cerebrospinal fluid (CSF) dynamics in the spinal subarachnoid space (SSS) have been thought to play an important pathophysiological role in syringomyelia, Chiari I malformation (CM), and a role in intrathecal drug delivery. Yet, the impact that fine
Externí odkaz:
https://doaj.org/article/4394a7cddc5243158e29084a02807da4
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75335 (2013)
Elevated or reduced velocity of cerebrospinal fluid (CSF) at the craniovertebral junction (CVJ) has been associated with type I Chiari malformation (CMI). Thus, quantification of hydrodynamic parameters that describe the CSF dynamics could help asses
Externí odkaz:
https://doaj.org/article/db1e93b23dda4b69a205f6757c59e8e7
Autor:
Theresia I Yiallourou, Jan Robert Kröger, Nikolaos Stergiopulos, David Maintz, Bryn A Martin, Alexander C Bunck
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52284 (2012)
Cerebrospinal fluid (CSF) dynamics in the cervical spinal subarachnoid space (SSS) have been thought to be important to help diagnose and assess craniospinal disorders such as Chiari I malformation (CM). In this study we obtained time-resolved three
Externí odkaz:
https://doaj.org/article/bbc102740bb04f06ad0d414473613f9b
Autor:
Stuart H. Sater, Gabryel Conley Natividad, Akari J. Seiner, Audrey Q. Fu, Dev Shrestha, Eric M. Bershad, Karina Marshall-Goebel, Steven S. Laurie, Brandon R. Macias, Bryn A. Martin
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 133(6)
Spaceflight associated neuro-ocular syndrome (SANS) is associated with acquired optic disc edema, hyperopia, and posterior globe flattening in some astronauts during long-duration spaceflight possibly due to the headward fluid redistribution in micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17b42276e0a7d97bdac3f322804a24c
https://pubmed.ncbi.nlm.nih.gov/36326472
https://pubmed.ncbi.nlm.nih.gov/36326472
Autor:
Akari Seiner, Goutham Kumar Reddy Burla, Dev Shrestha, Mayumi Bowen, Joshua D. Horvath, Bryn A. Martin
Publikováno v:
Frontiers in Neuroimaging. 1
BackgroundUnderstanding the relationship between cerebrospinal fluid (CSF) dynamics and intrathecal drug delivery (ITDD) injection parameters is essential to improve treatment of central nervous system (CNS) disorders.MethodsAn anatomically detailed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd3fe7af5b5904d9b539cb343f18935c
https://doi.org/10.3389/fnimg.2022.879098
https://doi.org/10.3389/fnimg.2022.879098