Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Bryce G, Johnson"'
Autor:
Yeawon Kim, Chuang Li, Chenjian Gu, Yili Fang, Eric Tycksen, Anuradhika Puri, Terri A. Pietka, Jothilingam Sivapackiam, Kendrah Kidd, Sun-Ji Park, Bryce G. Johnson, Stanislav Kmoch, Jeremy S. Duffield, Anthony J. Bleyer, Meredith E. Jackrel, Fumihiko Urano, Vijay Sharma, Maria Lindahl, Ying Maggie Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading hereditary kidney disease. There are no targeted therapies. In our
Externí odkaz:
https://doaj.org/article/72c2d4d2fcd54509bc61bc5046fee857
Autor:
Ju Wang, Agustin Casimiro-Garcia, Bryce G. Johnson, Jennifer Duffen, Michael Cain, Leigh Savary, Stephen Wang, Prashant Nambiar, Matthew Lech, Shanrong Zhao, Li Xi, Yutian Zhan, Jennifer Olson, James A. Stejskal, Hank Lin, Baohong Zhang, Robert V. Martinez, Katherine Masek-Hammerman, Franklin J. Schlerman, Ken Dower
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Type 2 diabetes (T2D) and its complications can have debilitating, sometimes fatal consequences for afflicted individuals. The disease can be difficult to control, and therapeutic strategies to prevent T2D-induced tissue and organ damage are
Externí odkaz:
https://doaj.org/article/794a53c2283d4e51a4aee2e57be81772
Autor:
Elizabeth E. Marr, Thomas J. Mulhern, Michaela Welch, Philip Keegan, Celia Caballero-Franco, Bryce G. Johnson, Marion Kasaian, Hesham Azizgolshani, Timothy Petrie, Joseph Charest, Elizabeth Wiellette
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The intestinal epithelium comprises diverse cell types and executes many specialized functions as the primary interface between luminal contents and internal organs. A key function provided by the epithelium is maintenance of a barrier that
Externí odkaz:
https://doaj.org/article/1833cfd34b4e4f38827ff34d22a11b00
Autor:
Ken Dower, Shanrong Zhao, Franklin J Schlerman, Leigh Savary, Gabriela Campanholle, Bryce G Johnson, Li Xi, Vuong Nguyen, Yutian Zhan, Matthew P Lech, Ju Wang, Qing Nie, Morten A Karsdal, Federica Genovese, Germaine Boucher, Thomas P Brown, Baohong Zhang, Bruce L Homer, Robert V Martinez
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181861 (2017)
ZSF1 rats exhibit spontaneous nephropathy secondary to obesity, hypertension, and diabetes, and have gained interest as a model system with potentially high translational value to progressive human disease. To thoroughly characterize this model, and
Externí odkaz:
https://doaj.org/article/c8649b6e74a94a41b0cb26d57a6ac938
Autor:
Scott A Jelinsky, Merel Derksen, Eric Bauman, Carla S Verissimo, Wies T M van Dooremalen, Jamie Lee Roos, Celia Higuera Barón, Celia Caballero-Franco, Bryce G Johnson, Michelle G Rooks, Johanna Pott, Bas Oldenburg, Robert G J Vries, Sylvia F Boj, Marion T Kasaian, Farzin Pourfarzad, Charles V Rosadini
Publikováno v:
Inflammatory bowel diseases.
Background Patient-derived organoid (PDO) models offer potential to transform drug discovery for inflammatory bowel disease (IBD) but are limited by inconsistencies with differentiation and functional characterization. We profiled molecular and cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f32b4dc5502df57f0facfdee5d71ce9
https://pubmed.ncbi.nlm.nih.gov/36356046
https://pubmed.ncbi.nlm.nih.gov/36356046
Autor:
Jeremiah J. Morrissey, Ying Maggie Chen, Chuang Li, Zheyu Wang, Stanislav Kmoch, Jeremy S. Duffield, Yeawon Kim, Kendrah Kidd, Yixuan Wang, Bryce G. Johnson, Srikanth Singamaneni, Anthony J. Bleyer
Publikováno v:
Am J Physiol Renal Physiol
Autosomal dominant tubulointerstitial kidney disease (ADTKD)-uromodulin (UMOD) is the most common nonpolycystic genetic kidney disease, but it remains unrecognized due to its clinical heterogeneity and lack of screening test. Moreover, the fact that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4417633b6061fceee9e9b8c864dbe165
https://europepmc.org/articles/PMC8424663/
https://europepmc.org/articles/PMC8424663/
Autor:
Jeremy S. Duffield, Joseph V. Bonventre, Guanghai Wang, Julia Wilflingseder, Michael McMurdo, Koichiro Susa, Ryuji Morizane, Dario R. Lemos, Irina A. Leaf, Navin Gupta, Gamze Karaca, Tomoya Miyoshi, Kirolous Soliman, Bryce G. Johnson
Publikováno v:
Journal of the American Society of Nephrology. 29:1690-1705
Background Kidney injury is characterized by persisting inflammation and fibrosis, yet mechanisms by which inflammatory signals drive fibrogenesis remain poorly defined.Methods RNA sequencing of fibrotic kidneys from patients with CKD identified a me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34ca659a31ebfe0af9027ed0cb3c934c
https://doi.org/10.1681/asn.2017121283
https://doi.org/10.1681/asn.2017121283
Autor:
Lionel Feigenbaum, Jeremy S. Duffield, Zebulon G. Levine, Bryce G. Johnson, Deepak Reyon, Lan T.H. Dang, Allie M. Roach, Anthony Monti, Graham Marsh
Publikováno v:
Journal of Clinical Investigation. 127:3954-3969
Uromodulin-associated kidney disease (UAKD) is caused by mutations in the uromodulin (UMOD) gene that result in a misfolded form of UMOD protein, which is normally secreted by nephrons. In UAKD patients, mutant UMOD is poorly secreted and accumulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876d471f031eda85e7264dc1615f5b7f
https://doi.org/10.1172/jci93817
https://doi.org/10.1172/jci93817
Autor:
Angela Huang, Chris Sparages, Roberto F. Nicosia, Jeremy S. Duffield, Lan T.H. Dang, Christopher S. Chen, Sarah Kate Read, Christine Yoon, Takahide Aburatani, Graham Marsh, Stella Alimperti, Suzanne Szak, Naoki Nakagawa, Ivan G. Gomez, Bryce G. Johnson, Shuyu Ren, Giovanni Ligresti, Alfred C. Aplin
Publikováno v:
Biomaterials. 141:314-329
Loss of the microvascular (MV) network results in tissue ischemia, loss of tissue function, and is a hallmark of chronic diseases. The incorporation of a functional vascular network with that of the host remains a challenge to utilizing engineered ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25560b26fb7f4837134bf438132270a9
https://doi.org/10.1016/j.biomaterials.2017.07.010
https://doi.org/10.1016/j.biomaterials.2017.07.010
Autor:
Jeremy S. Duffield, Jin Joo Cha, Irina A. Leaf, Ivan G. Gomez, Kristen Mittelsteadt, Bryce G. Johnson, William A. Altemeier, Kevin Guckian, Shunsaku Nakagawa
Publikováno v:
Journal of Clinical Investigation. 127:321-334
Fibrotic disease is associated with matrix deposition that results in the loss of organ function. Pericytes, the precursors of myofibroblasts, are a source of pathological matrix collagens and may be promising targets for treating fibrogenesis. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b920c9f24ee958c8ca0f1605a87777b0
https://doi.org/10.1172/jci87532
https://doi.org/10.1172/jci87532