Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bryce A. Manso"'
Autor:
Baustin M. Welch, Bryce A. Manso, Kimberly A. Gwin, Petra K. Lothert, Sameer A. Parikh, Neil E. Kay, Kay L. Medina
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD19+ CD5+ clonal B lymphocytes in the blood, bone marrow, and peripheral lymphoid organs. Treatment options for patients range from historical chemoimmunotherapy (CIT) to sma
Externí odkaz:
https://doaj.org/article/3af2d62a88864d4880ba353b1c54c869
Publikováno v:
Cells, Vol 13, Iss 8, p 704 (2024)
Platelets are the terminal progeny of megakaryocytes, primarily produced in the bone marrow, and play critical roles in blood homeostasis, clotting, and wound healing. Traditionally, megakaryocytes and platelets are thought to arise from multipotent
Externí odkaz:
https://doaj.org/article/f66ede4078a54442880e764eacabbb6a
Autor:
Alessandra Rodriguez y Baena, Smrithi Rajendiran, Bryce A. Manso, Jana Krietsch, Scott W. Boyer, Jessica Kirschmann, E. Camilla Forsberg
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Hematopoietic stem cell (HSC) multipotency and self-renewal are typically defined through serial transplantation experiments. Host conditioning is necessary for robust HSC engraftment, likely by reducing immune-mediated rejection and by clea
Externí odkaz:
https://doaj.org/article/308fd9340624467b9ed13e10406e258b
Autor:
Bryce A. Manso, Kay L. Medina
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100485- (2021)
Summary: Transcription factor (TF) expression levels drive developmental programs, including cell fate and function, and their measurement by flow cytometry allows for robust downstream analysis. However, significant batch-to-batch variability betwee
Externí odkaz:
https://doaj.org/article/01b1df4413e6426ca85406f09371f1f9
Autor:
Bryce A. Manso, Jordan E. Krull, Kimberly A. Gwin, Petra K. Lothert, Baustin M. Welch, Anne J. Novak, Sameer A. Parikh, Neil E. Kay, Kay L. Medina
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101994- (2021)
Summary: TNFα is implicated in chronic lymphocytic leukemia (CLL) immunosuppression and disease progression. TNFα is constitutively produced by CLL B cells and is a negative regulator of bone marrow (BM) myelopoiesis. Here, we show that co-culture
Externí odkaz:
https://doaj.org/article/3512d80d493a465ba952a1c7986839c3
Publikováno v:
Exp Hematol
Hematopoietic stem cells (HSCs) have been studied extensively since their initial functional description in 1961 when Dr. James Till and Dr. Ernest McCulloch developed the first in vivo clonal strategy, termed the "spleen colony-forming unit" (CFU-S)
Autor:
Kay L. Medina, Petra K. Lothert, Sameer A. Parikh, Bryce A. Manso, Neil E. Kay, Anne J. Novak, Kimberly A. Gwin, Baustin M. Welch, Jordan E. Krull
Publikováno v:
iScience
iScience, Vol 24, Iss 1, Pp 101994-(2021)
iScience, Vol 24, Iss 1, Pp 101994-(2021)
Summary TNFα is implicated in chronic lymphocytic leukemia (CLL) immunosuppression and disease progression. TNFα is constitutively produced by CLL B cells and is a negative regulator of bone marrow (BM) myelopoiesis. Here, we show that co-culture o
Autor:
Bryce A. Manso, Charla R. Secreto, Neil E. Kay, Anne J. Novak, Wei Ding, Kimberly A. Gwin, Jordan E. Krull, Petra K. Lothert, Sameer A. Parikh, Kay L. Medina
Publikováno v:
Blood. 134:4276-4276
The current paradigms of known peripheral immune abnormalities in B-Chronic Lymphocytic Leukemia (CLL) are not able to consistently explain patient complications and it is difficult to correct a given CLL patient's immune status. Here, we expand on o
Autor:
Wei Ding, Kimberly A. Gwin, Henan Zhang, Neil E. Kay, Sameer A. Parikh, Kay L. Medina, Charla R. Secreto, Bryce A. Manso, Molly G. Mikkelson
Publikováno v:
Leukemia. 33(3)
The consequences of immune dysfunction in B-chronic lymphocytic leukemia (CLL) likely relate to the incidence of serious recurrent infections and second malignancies that plague CLL patients. The well-described immune abnormalities are not able to co
Autor:
Virginia Smith Shapiro, Derek B.Sant Angelo, Puspa Thapa, Sinibaldo Romera Arocha, Ji Young Chung, Bryce A. Manso, Hai Hui Xue
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
iNKT cells are a unique lineage of T cells that recognize glycolipid presented by CD1d. In the thymus, they differentiate into iNKT1, iNKT2 and iNKT17 effector subsets, characterized by preferential expression of Tbet, Gata3 and ROR-γt and productio