Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Bryan Wetzel"'
Autor:
Sean P. Ebert, Bryan Wetzel, Gwenaëlle Conseil, Susan P.C. Cole, Michael R. Detty, Robert L. Myette
Publikováno v:
Drug Metabolism and Disposition. 41:1231-1239
Multidrug resistance proteins (MRPs) mediate the ATP-dependent efflux of structurally diverse compounds, including anticancer drugs and physiologic organic anions. Five classes of chalcogenopyrylium dyes (CGPs) were examined for their ability to modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447212fcd64ae776d2ad704ce3ad1210
https://doi.org/10.1124/dmd.112.050831
https://doi.org/10.1124/dmd.112.050831
Autor:
Thomas J. Raub, M. Claire Bartlett, Tip W. Loo, Jason J. Holt, Michael R. Detty, Michael K. Gannon, Stephanie M. Bennett, Gregory Tombline, David M. Clarke, J. William Higgins, Bryan Wetzel, Geri A. Sawada
Publikováno v:
Journal of Medicinal Chemistry. 52:3328-3341
We have examined 46 tetramethylrosamine/rhodamine derivatives with structural diversity in the heteroatom of the xanthylium core, the amino substituents of the 3- and 6-positions, and the alkyl, aryl, or heteroaryl group at the 9-substituent. These c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30a95b93a7a01c466e6dbeb74f94748
https://doi.org/10.1021/jm900253g
https://doi.org/10.1021/jm900253g
Autor:
Michael R. Detty, Andrey Skripchenko, Bryan Wetzel, Mao Ye, Tymish Y. Ohulchanskyy, Sadia Sahabi, Stephen J. Wagner, Ruel E. McKnight
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:4406-4418
A series of thio- and selenopyrylium analogues of 2,4-di(4-dimethylaminophen-yl)-6-methylthiopyrylium iodide were prepared in five steps from 4-dimethylaminophenyl-propargyl aldehyde and the corresponding lithium acetylide. When bound to DNA, all of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be07efcd9fb675c670b8d98bbb975f2
https://doi.org/10.1016/j.bmc.2007.04.033
https://doi.org/10.1016/j.bmc.2007.04.033
Autor:
Sean P. Ebert, Bryan Wetzel, Geri A. Sawada, Michael R. Detty, Robert L. Myette, David M. Clarke, Gwenaëlle Conseil, Tip W. Loo, M. Claire Bartlett, Susan P.C. Cole
Publikováno v:
Journal of medicinal chemistry. 55(10)
Twenty-seven chalcogenopyrylium derivatives varying in the heteroatom of the pyrylium core and substituents at the 2-, 4-, and 6-positions were examined for their effect on human MRP1-mediated uptake of tritiated estradiol glucuronide into inside-out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c19a0cd03c2a4a6c127b1973ec9cf9
https://pubmed.ncbi.nlm.nih.gov/22533905
https://pubmed.ncbi.nlm.nih.gov/22533905
Autor:
Jason J. Holt, Thomas J. Raub, Bryan Wetzel, Geri A. Sawada, Gregory Tombline, Michael R. Detty, Michael K. Gannon, David J. Donnelly
Publikováno v:
Biochemistry. 47(10)
The multidrug efflux pump P-glycoprotein (Pgp) couples drug transport to ATP hydrolysis. Previously, using a synthetic library of tetramethylrosamine ( TMR) analogues, we observed significant variation in ATPase stimulation ( V m (D)). Concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526c3151d2258cbac69c4fc302a40b96
https://pubmed.ncbi.nlm.nih.gov/18275155
https://pubmed.ncbi.nlm.nih.gov/18275155