Cannabis Use and Mental Illness: Understanding Circuit Dysfunction Through Preclinical Models

Autor: Bryan W. Jenkins, Jibran Y. Khokhar

Publikováno v: Frontiers in Psychiatry, Vol 12 (2021)

Patients with a serious mental illness often use cannabis at higher rates than the general population and are also often diagnosed with cannabis use disorder. Clinical studies reveal a strong association between the psychoactive effects of cannabis a

Externí odkaz: https://doaj.org/article/73a8fdc6bbbf4c5b9616e08abbb52829

Clozapine Increases Nestin Concentration in the Adult Male Rat Hippocampus: A Preliminary Study

Autor: Hakan Kayir, Bryan W. Jenkins, Begüm Alural, Jibran Y. Khokhar

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3436
Neuroscience Institute Publications

Patients with schizophrenia, and rodent models of the disease, both exhibit suppressed neurogenesis, with antipsychotics possibly enhancing neurogenesis in pre-clinical models. Nestin, a cytoskeletal protein, is implicated in neuronal differentiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502417130bec63ee31ecf369e01a6cdf
https://pubmed.ncbi.nlm.nih.gov/35408792

Cannabis Vapor Exposure Alters Neural Circuit Oscillatory Activity in a Neurodevelopmental Model of Schizophrenia: Exploring the Differential Impact of Cannabis Constituents

Autor: Bryan W. Jenkins, Jibran Y. Khokhar, Melissa L. Perreault, Buckhalter S

Publikováno v: Schizophrenia Bulletin Open
Neuroscience Institute Publications

Cannabis use is highly prevalent in patients with schizophrenia and worsens the course of the disorder. To understand how exposure to cannabis changes schizophrenia-related oscillatory disruptions, we investigated the impact of administering cannabis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe8ae9437e38a2c587576b4ef42f162
https://pubmed.ncbi.nlm.nih.gov/35036917

EXTENDED ATTENUATION OF CORTICOSTRIATAL POWER AND COHERENCE AFTER ACUTE EXPOSURE TO VAPOURIZED Δ9 TETRAHYDROCANNABINOL IN RATS

Autor: Tapia Foute Nelong, Melissa L. Perreault, Jibran Y. Khokhar, Bryan W. Jenkins

Publikováno v: Can J Addict

Introduction Over 14% of Canadians use cannabis, with nearly 60% of these individuals reporting daily or weekly use. Inhalation of cannabis vapour has recently gained popularity, but the effects of this exposure on neural activity remain unknown. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e43b6da33f6a4be81b0a9e0ac4eb61b
https://pubmed.ncbi.nlm.nih.gov/32944610

Place field repetition and spatial learning in a multicompartment environment

Autor: Bruce Harland, Paul A. Dudchenko, Roddy M. Grieves, Emma R. Wood, Bryan W. Jenkins

Publikováno v: Hippocampus
Grieves, R M, Jenkins, B W, Harland, B, Wood, E R & Dudchenko, P A 2016, ' Place field repetition and spatial learning in a multicompartment environment ', Hippocampus, vol. 26, no. 1, pp. 118-134 . https://doi.org/10.1002/hipo.22496

Recent studies have shown that place cells in the hippocampus possess firing fields that repeat in physically similar, parallel environments. These results imply that it should be difficult for animals to distinguish parallel environments at a behavi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc56d0983cb3ea102fd23c082ea2d40
https://doi.org/10.1002/hipo.22496