Zobrazeno 1 - 10
of 469
pro vyhledávání: '"Bryan T Grenfell"'
Autor:
Chadi M Saad-Roy, Sinead E Morris, Mike Boots, Rachel E Baker, Bryan L Lewis, Jeremy Farrar, Madhav V Marathe, Andrea L Graham, Simon A Levin, Caroline E Wagner, C Jessica E Metcalf, Bryan T Grenfell
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 8, p e1012211 (2024)
The SARS-CoV-2 pandemic has generated a considerable number of infections and associated morbidity and mortality across the world. Recovery from these infections, combined with the onset of large-scale vaccination, have led to rapidly-changing popula
Externí odkaz:
https://doaj.org/article/a34513b233704ad2a385f1cd24acf2f0
Autor:
Bjarke Frost Nielsen, Chadi M Saad-Roy, Yimei Li, Kim Sneppen, Lone Simonsen, Cécile Viboud, Simon A Levin, Bryan T Grenfell
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 2, p e1010896 (2023)
Identifying drivers of viral diversity is key to understanding the evolutionary as well as epidemiological dynamics of the COVID-19 pandemic. Using rich viral genomic data sets, we show that periods of steadily rising diversity have been punctuated b
Externí odkaz:
https://doaj.org/article/60e6ac8315c74e3288ac9599ef3805f4
Autor:
Wha-Eum Lee, Sang Woo Park, Daniel M Weinberger, Donald Olson, Lone Simonsen, Bryan T Grenfell, Cécile Viboud
Publikováno v:
eLife, Vol 12 (2023)
Excess mortality studies provide crucial information regarding the health burden of pandemics and other large-scale events. Here, we use time series approaches to separate the direct contribution of SARS-CoV-2 infection on mortality from the indirect
Externí odkaz:
https://doaj.org/article/cd356fbca8574380a454a5c6b949ac16
Autor:
Max S Y Lau, Alex Becker, Wyatt Madden, Lance A Waller, C Jessica E Metcalf, Bryan T Grenfell
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010251 (2022)
Measles is one the best-documented and most-mechanistically-studied non-linear infectious disease dynamical systems. However, systematic investigation into the comparative performance of traditional mechanistic models and machine learning approaches
Externí odkaz:
https://doaj.org/article/a9ba7faa45f2465db4a37aa3cf6b027c
Autor:
John R Giles, Derek A T Cummings, Bryan T Grenfell, Andrew J Tatem, Elisabeth Zu Erbach-Schoenberg, Cje Metcalf, Amy Wesolowski
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009127 (2021)
Human travel is one of the primary drivers of infectious disease spread. Models of travel are often used that assume the amount of travel to a specific destination decreases as cost of travel increases with higher travel volumes to more populated des
Externí odkaz:
https://doaj.org/article/bcb974793f1b4f99beefc62160a2da4f
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009347 (2021)
[This corrects the article DOI: 10.1371/journal.pntd.0008048.].
Externí odkaz:
https://doaj.org/article/cdfe639df11344a7bed46a6fc159bd09
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009105 (2020)
Health outcomes following infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) are remarkably variable. The way the virus spreads inside hosts, and how this spread interacts with host immunity and physiology, is likely to deter
Externí odkaz:
https://doaj.org/article/6820f1d4bafd41ff807dddd6902d9cc5
Autor:
Dylan H Morris, Velislava N Petrova, Fernando W Rossine, Edyth Parker, Bryan T Grenfell, Richard A Neher, Simon A Levin, Colin A Russell
Publikováno v:
eLife, Vol 9 (2020)
Seasonal influenza viruses create a persistent global disease burden by evolving to escape immunity induced by prior infections and vaccinations. New antigenic variants have a substantial selective advantage at the population level, but these variant
Externí odkaz:
https://doaj.org/article/afd621eeec6347359c44a39046a145c0
Autor:
Chadi M Saad-Roy, Nimalan Arinaminpathy, Ned S Wingreen, Simon A Levin, Joshua M Akey, Bryan T Grenfell
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007892 (2020)
Seasonal influenza A viruses of humans evolve rapidly due to strong selection pressures from host immune responses, principally on the hemagglutinin (HA) viral surface protein. Based on mouse transmission experiments, a proposed mechanism for immune
Externí odkaz:
https://doaj.org/article/4beb7a1f06af4933ae769a0b78caf718
Autor:
Michael J Mina, C Jessica E Metcalf, Adrian B McDermott, Daniel C Douek, Jeremy Farrar, Bryan T Grenfell
Publikováno v:
eLife, Vol 9 (2020)
SARS-CoV-2 presents an unprecedented international challenge, but it will not be the last such threat. Here, we argue that the world needs to be much better prepared to rapidly detect, define and defeat future pandemics. We propose that a Global Immu
Externí odkaz:
https://doaj.org/article/c1ab745f0f1545b0b68b0f9ced7c18ae