Výsledky vyhledávání - "Bryan Safratowich"

Superior inhibitory efficacy of butyrate over propionate and acetate against human colon cancer cell proliferation via cell cycle arrest and apoptosis: linking dietary fiber to cancer prevention

Autor: Stephanie K. Hamlin, Huawei Zeng, LuAnn K. Johnson, Wen-Hsing Cheng, Bryan Safratowich

Publikováno v: Nutrition Research. 83:63-72

Intake of dietary fiber may protect against colon cancer. The anticancer property is associated with an increased production of short chain fatty acids (SCFAs), including acetate, propionate and butyrate, during dietary fiber fermentation in the colo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acae33b39b69aec8933bfe6a3bac17ca
https://doi.org/10.1016/j.nutres.2020.08.009

Zobrazit plný text záznamu

Inulin Improves Insulin Sensitivity, Changes Cecal Bile Acids, but Does Not Mitigate Hepatic Steatosis from an Obesogenic, High Fat Diet

Autor: Matthew J. Picklo, Michael R. Bukowski, Joseph Idso, Bryan Safratowich, Huawei Zeng, Bret Rust

Publikováno v: Curr Dev Nutr

OBJECTIVES: Obesogenic, high fat diets (HFD) increase hepatic long chain polyunsaturated fatty acid content (LCPUFA), but also lead to hepatic steatosis and insulin resistance. Fermentable fiber such as inulin (INU) may reduce these negative outcomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e8fbef349fd0b36672eba557665fd8
https://europepmc.org/articles/PMC7257546/

Zobrazit plný text záznamu

Superior Inhibitory Efficacy of Butyrate over Propionate and Acetate Against Human Colon Cancer Cell Proliferation via Cell Cycle Arrest and Apoptosis

Autor: Bryan Safratowich, LuAnn K. Johnson, Huawei Zeng, Stephanie Hamlin, Wen-Hsing Cheng

Publikováno v: Curr Dev Nutr

OBJECTIVES: Intake of fiber has beneficial properties for gut health. These effects may be due to the increased production of short chain fatty acids (SCFAs) such as acetate, propionate and butyrate during dietary fiber fermentation in the colon. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44b89b108d2270368f724c4eea3ceeb
https://europepmc.org/articles/PMC7258433/

Zobrazit plný text záznamu

Deoxycholic Acid Modulates Cell-Junction Gene Expression and Increases Intestinal Barrier Dysfunction in Caco-2 Cell Monolayers

Autor: Kate J. Claycombe-Larson, Bryan Safratowich, Wen-Hsing Cheng, Huawei Zeng, Mary Briske-Anderson

Publikováno v: Curr Dev Nutr

OBJECTIVES: Diet-related obesity is associated with an increased risk of developing intestinal hyperpermeability. High dietary fat intake causes an increase in colonic bile acids (BAs), particularly deoxycholic acid (DCA, secondary BA), which may dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b10fb4b68d8b0d0ce9babda3340a36b
https://doi.org/10.1093/cdn/nzab050_023

Zobrazit plný text záznamu

Adequacy of calcium and vitamin D reduces inflammation, β-catenin signaling, and dysbiotic Parasutterela bacteria in the colon of C57BL/6 mice fed a western-style diet

Autor: Bryan Safratowich, Michael R. Bukowski, Zhenhua Liu, Suzanne L. Ishaq, Huawei Zeng

Publikováno v: The Journal of Nutritional Biochemistry. 92:108613

Adoption of an obesogenic diet low in calcium and vitamin D (CaD) leads to increased obesity, colonic inflammation, and cancer. However, the underlying mechanisms remain to be elucidated. We tested the hypothesis that CaD supplementation (from inadeq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72844773530bfe39169f99d1d858073e
https://doi.org/10.1016/j.jnutbio.2021.108613

Zobrazit plný text záznamu

Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet

Autor: Zhenhua Liu, Wen-Hsing Cheng, Michael R. Bukowski, Reza Hakkak, Bryan Safratowich, Kate J. Larson, Huawei Zeng

Publikováno v: The Journal of nutritional biochemistry. 78

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries, and the gut-liver axis is implicated in liver disease pathogenesis. We hypothesize that advanced liver steatosis accompanies an increase in hepati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5450f85892b528770f58a4fc40ac2acc
https://pubmed.ncbi.nlm.nih.gov/32004929

Zobrazit plný text záznamu

Supplementation of Calcium and Vitamin D Reduces Colonic Inflammation and Beta-Catenin Signaling in C57BL/6 Mice Fed a Western Diet

Autor: Michael R. Bukowski, Zhenhua Liu, Huawei Zeng, Suzanne L. Ishaq, Bryan Safratowich

Publikováno v: Curr Dev Nutr

OBJECTIVES: Adoption of a Western diet, low in calcium and vitamin D (CaD), is a global problem leading to increased obesity, colonic inflammation and neoplasia. However, the mechanisms underlying this relationship remains to be elucidated. We tested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa54a520958deb0329e33464816f5bb
https://doi.org/10.1093/cdn/nzaa063_105

Zobrazit plný text záznamu

Butyrate Inhibits Deoxycholic‐Acid‐Resistant Colonic Cell Proliferation via Cell Cycle Arrest and Apoptosis: A Potential Pathway Linking Dietary Fiber to Cancer Prevention

Autor: Stephanie K. Hamlin, LuAnn K. Johnson, Bryan Safratowich, Huawei Zeng, Thomas T.Y. Wang

Publikováno v: Molecular Nutrition & Food Research. 64:1901014

Scope Butyrate, an intestinal microbiota metabolite of dietary fiber, exhibits colon cancer preventive effects. In contrast, a high fat intake increases fecal secondary bile acids, such as deoxycholic acid (DCA, a potential cancer promoter), which se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a5e6d1b0caf554379e8646031f6f7b
https://doi.org/10.1002/mnfr.201901014

Zobrazit plný text záznamu

Advanced Liver Steatosis Accompanies an Increase in the Level of Colonic Pro-inflammatory Bile Acids and Hepatic Inflammation in C57BL/6 Mice Fed a High-fat Diet (P15-027-19)

Autor: Reza Hakkak, Kate Larson, Michael R. Bukowski, Huawei Zeng, Bryan Safratowich, Wen-Hsing Cheng

Publikováno v: Current Developments in Nutrition. 3:nzz037.P15-027

OBJECTIVES: The gut-liver axis is implicated in the pathogenesis of liver diseases; however, the mechanistic link between the gut and fatty liver disease severity remains to be characterized. We tested the hypothesis that advanced liver-steatosis acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399ec1b524661a6266210769197404d8
https://doi.org/10.1093/cdn/nzz037.p15-027-19

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání