Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Bryan S. Margulies"'
Publikováno v:
Journal of Orthopaedic Research. 34:1195-1205
Chronic opioid therapy is associated with bone loss. This led us to hypothesize that the opioid antagonists, that include naloxone, would stimulate bone formation by regulating MSC differentiation. The opioid growth factor receptor (OGFR) is a non-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::666d7db56ab78d543684f1dd85163ced
https://doi.org/10.1002/jor.23135
https://doi.org/10.1002/jor.23135
Autor:
Bryan S. Margulies, Adrienne M. Parsons, Jessica S.S. Ee, Timothy S. Damron, Sean D. DeBoyace, Connor G. Policastro
Publikováno v:
Journal of Orthopaedic Research. 33:615-624
We sought to demonstrate whether there is a difference in the local mesenchymal stem cells (MSC) niche obtained from patients undergoing their first total joint replacement surgery versus those patients undergoing a revision surgery for an failing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc93204d12b7c10240fe718c3847514b
https://doi.org/10.1002/jor.22790
https://doi.org/10.1002/jor.22790
Publikováno v:
Stem Cells and Development. 23:2336-2351
Here, we show that Src homology 2-domain-containing inositol 5′-phosphatase 1 (SHIP1) is required for the efficient development of osteoblasts from mesenchymal stem cells (MSCs) such that bone growth and density are reduced in mice that lack SHIP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf02e2ed6da34926ce74e695f71e9114
https://doi.org/10.1089/scd.2014.0122
https://doi.org/10.1089/scd.2014.0122
Publikováno v:
Annals of the New York Academy of Sciences. 1280:11-14
The bone marrow milieu comprising both hematopoietic and nonhematopoietic lineages has a unique structural organization. Bone undergoes continuous remodeling throughout life. This dynamic process involves a balance between bone-forming osteoblasts (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3794046b3a1c6e44fbf4457463edc782
https://doi.org/10.1111/nyas.12091
https://doi.org/10.1111/nyas.12091
Publikováno v:
Journal of Tissue Science & Engineering. 7
The field of tissue engineering is still seeking a viable substitute to repair and replace damaged bone using a combination of porous implants, biochemical factors, and relevant cell types. While progress in this field has been made, current engineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82abae414191c711afc18597842cb54f
https://doi.org/10.4172/2157-7552.1000173
https://doi.org/10.4172/2157-7552.1000173
Ewing's sarcoma of bone is a primary childhood malignancy of bone that is treated with X-radiation therapy in combination with surgical excision and chemotherapy. To better study Ewing's sarcoma of bone we developed a novel model of primary Ewing's s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf30f5290ce6b056b7f2dd734e79b65
https://europepmc.org/articles/PMC4501857/
https://europepmc.org/articles/PMC4501857/
Autor:
Cornelia E. Farnum, Timothy A. Damron, Joseph A. Spadaro, Jason A. Horton, Jason T. Bariteau, Judith A. Strauss, Bryan S. Margulies
Publikováno v:
Journal of Orthopaedic Research. 24:1945-1956
Radiation therapy encompassing an active epiphysis can negatively impact the potential for bone growth by disrupting cell-cycle progression and accelerating apoptosis and terminal differentiation in physeal chondrocytes. Despite functional derangemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8022cbc867e52128d045822905d2e030
https://doi.org/10.1002/jor.20251
https://doi.org/10.1002/jor.20251
Publikováno v:
Calcified Tissue International. 78:302-313
The negative irradiation complications of growth loss leading to limb length asymmetry and pathological fracture incurred following radiation therapy in pediatric patients has led to a renewed interest in understanding the specific effects of irradia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57e10fbfd9b2dbcdeb891199226b481
https://doi.org/10.1007/s00223-005-0135-3
https://doi.org/10.1007/s00223-005-0135-3
Autor:
Jay Luther, Bryan S. Margulies, Judith A. Strauss, Cornelia E. Farnum, Joseph A. Spadaro, Jason A. Horton, Timothy A. Damron
Publikováno v:
International Journal of Radiation Biology. 81:759-765
The aim of this study was to determine if fractionation and individual or combinations of radioprotectants could minimize damage to physeal longitudinal growth in an animal model to any greater extent than fractionation alone.Sixty-three weanling mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a1aa71e013502da94325abcbeae445
https://doi.org/10.1080/09553000500495710
https://doi.org/10.1080/09553000500495710
Autor:
Timothy A. Damron, Cornelia E. Farnum, Bryan S. Margulies, Judith A. Strauss, Jason A. Horton, Joseph A. Spadaro
Publikováno v:
Clinical Orthopaedics and Related Research. 426:110-116
Radiotherapy used in the treatment of bone and soft tissue sarcomas in pediatric patients often results in undesirable growth plate damage. Radioprotectants may hold promise in the selective protection of growth plate tissue in this setting. In an an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8548725431b0ad5d190ffb1dc525f50a
https://doi.org/10.1097/01.blo.0000131247.18112.0f
https://doi.org/10.1097/01.blo.0000131247.18112.0f