Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bryan R. Reep"'
Autor:
Andrea M. Sefler, Timothy D. Spitzer, Edgar R. Wood, O. Bradley McDonald, Bryan R. Reep, Eric E. Boros, James B. Thompson
Publikováno v:
Journal of Heterocyclic Chemistry. 41:355-358
5-Methoxy and 5-anilinopyrido[2,3-d]pyrimidin-7(8H)-ones 2a-2f were obtained by a tandem Michael addition-cyclization reaction of methanol and anilines with pyrimidinylpropynoate 5. Methoxy derivative 2a was obtained in 62% yield by treatment of 5 wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2678f8ce6bf7b778ba81cf5560bdc26e
https://doi.org/10.1002/jhet.5570410308
https://doi.org/10.1002/jhet.5570410308
Autor:
Bryan R. Reep, Eduardo G. Lapetina
Publikováno v:
Biochemical and Biophysical Research Communications. 219:1-5
Phosphorylation of rap1b in human platelets correlates with both an upward shift of the protein on sodium dodecyl sulfate polyacrylamide gels and the translocation of the phosphorylated protein to the cytosolic fraction of platelets. We reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af023f8df9f4e8c9b4a2a97ea16c504
https://doi.org/10.1006/bbrc.1996.0171
https://doi.org/10.1006/bbrc.1996.0171
Publikováno v:
Biochemistry. 32:11600-11605
A combination of cytokines induced the expression of nitric oxide synthase (NOS) in a human colorectal adenocarcinoma cell line, DLD-1. We have purified the enzyme and examined some of its biochemical properties. An antiserum to an inducible NOS from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbab5d48d1e04315718c0aa2aa7a6ab7
https://doi.org/10.1021/bi00094a017
https://doi.org/10.1021/bi00094a017
Publikováno v:
Journal of Biological Chemistry. 266:4375-4380
Polyclonal antisera were generated against synthetic peptides corresponding to distinct regions of the rap 1 protein sequences. A "rap 1-common" antiserum, prepared against an 18-amino acid segment of the rap 1a protein near the proposed GTP-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6786d1a1e595deb0539f6eff7ce3fbcc
https://doi.org/10.1016/s0021-9258(20)64332-0
https://doi.org/10.1016/s0021-9258(20)64332-0
Publikováno v:
Biochemical and Biophysical Research Communications. 174:1-5
A cDNA clone (Krev-1) has recently been identified that possesses the ability to reverse the transformed phenotype when introduced into a K-ras-transformed NIH 3 T 3 cell line. The Krev-1 protein, also known as rap-1A, was found to share 50% homology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fa282f32017dfb68c631c5aaa2fc00
https://doi.org/10.1016/0006-291x(91)90475-m
https://doi.org/10.1016/0006-291x(91)90475-m
Autor:
Alex G. Waterson, Michael J. Reno, Edgar R. Wood, Frederic Bouvier, David W. Rusnak, Sharon K. Rudolph, Yue-Mei Zhang, Krystal J. Alligood, David E. Uehling, Eric E. Boros, Kirk L. Stevens, Scott Howard Dickerson, Bryan R. Reep, Octerloney B. McDonald, Abdullah Rastagar
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
Anilinoalkynylpyrimidines were prepared and evaluated as dual EGFR/ErbB2 kinase inhibitors. A preference was found for substituted phenyl and heteroaromatic rings attached to the alkyne. In addition, the presence of a potential hydrogen bond donor ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c421d2e668d373936622e2d67c3cfbf2
https://pubmed.ncbi.nlm.nih.gov/16483772
https://pubmed.ncbi.nlm.nih.gov/16483772
Autor:
O. Bradley McDonald, Edgar R. Wood, Andrea M. Sefler, James B. Thompson, Timothy D. Spitzer, Eric E. Boros, Bryan R. Reep
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c190d4fd18cf0e4e6c05c4818c5413d
https://doi.org/10.1002/chin.200444178
https://doi.org/10.1002/chin.200444178
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 90(23)
Nitric oxide (NO) or NO-generating compounds like sodium nitroprusside (SNP) increase cellular levels of cGMP and produce S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase [GAPDH; D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572c04df7de61f160ce45c7db6d220f7
https://pubmed.ncbi.nlm.nih.gov/7902582
https://pubmed.ncbi.nlm.nih.gov/7902582
Autor:
Carol-Ann Ohmstede, Francis X. Farrell, Kenneth J. Clemetson, Eduardo G. Lapetina, Bryan R. Reep
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 87(17)
A platelet cDNA expression library was screened with the monoclonal antibody M90, which recognizes a specific epitope on RAS-encoded p21 proteins (amino acids 107-130). DNA sequence analysis of one clone revealed that it encoded a partial amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709be0f9530fdef5e22054600341c403
https://pubmed.ncbi.nlm.nih.gov/2118648
https://pubmed.ncbi.nlm.nih.gov/2118648
