Výsledky vyhledávání - "Bryan R. McDonald"

Figure S5 from Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

Autor: Ruth Y. Lan, Renu Jain, Jack Lohre, Sandra V. Hatcher, Kai Lu, Sharmila Sambanthamoorthy, Jeff Houser, Logan M. Vlach, Alan J. Korman, Tim W. Sproul, Mark Selby, Priti B. Singh, Nathan O. Siemers, Paul B. Mesko, Bryan R. McDonald, Joseph R. Campbell

Figure S5 shows human splenic and skin expressions of CCR8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea910d6113b477ee28be3a4efdb700d
https://doi.org/10.1158/0008-5472.22430338

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Figure S3 from Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

Binding, blocking and Fc engaging characteristics of anti-mouse CCR8 antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016495f6812d818c15b01c573011329b
https://doi.org/10.1158/0008-5472.22430344.v1

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Figure S2 from Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

Figure S2 shows single cell RNAseq analysis of CCR8+ and CCR8- subpopulations of tumor CD4+FOXP3+ T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3395427e5a32078333d9e31637ce537b
https://doi.org/10.1158/0008-5472.22430347

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Figure S4 from Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

Figure S4 shows donor immune cell reconstitution in the blood post Ccr8-/- donor bone marrow transplant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d25914e762bb5d5aa6d52f0e8a967ee
https://doi.org/10.1158/0008-5472.22430341

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Figure S6 from Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

Figure S6 shows lower FC receptor transcription in normal skin versus tumor tissues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fd27397d599f0d92fd1ee69a2739eb
https://doi.org/10.1158/0008-5472.22430335

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Supplemental Methods from Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

Supplemental materials and methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e367b24ef957365c6ae9ca9650d11e
https://doi.org/10.1158/0008-5472.22430326.v1

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Figure S7 from Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

Figure S7 shows 4T1 mouse tumor reductions resulting from anti-mCCR8 or anti-mCCR8/anti-mPD1 treatments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7702a09a88544996a2fa13d6d3f0dc83
https://doi.org/10.1158/0008-5472.22430332.v1

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Data from Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

FOXP3+ regulatory T cells (Treg) play a critical role in mediating tolerance to self-antigens and can repress antitumor immunity through multiple mechanisms. Therefore, targeted depletion of tumor-resident Tregs is warranted to promote effective anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31e7ef976adf7153577afb0d10288c03
https://doi.org/10.1158/0008-5472.c.6513598.v1

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Figure S8 from Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models

Figure S8 shows binding and CD16 cross-linking characteristics of anti-human CCR8 antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5013a8fa612c479d2bc6736c20530a4d
https://doi.org/10.1158/0008-5472.22430329

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