Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Bryan P. Early"'
Autor:
Pei Su, John P. McGee, Kenneth R. Durbin, Michael A. R. Hollas, Manxi Yang, Elizabeth K. Neumann, Jamie L. Allen, Bryon S. Drown, Fatma Ayaloglu Butun, Joseph B. Greer, Bryan P. Early, Ryan T. Fellers, Jeffrey M. Spraggins, Julia Laskin, Jeannie M. Camarillo, Jared O. Kafader, Neil L. Kelleher
Publikováno v:
Science advances. 8(32)
Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS), which increases the size limit for proteoform detection and identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b4e257e35227291c9bd87d3f9a773c
https://pubmed.ncbi.nlm.nih.gov/35947651
https://pubmed.ncbi.nlm.nih.gov/35947651
Autor:
Manxi Yang, Hang Hu, Pei Su, Paul M. Thomas, Jeannie M. Camarillo, Joseph B. Greer, Bryan P. Early, Ryan T. Fellers, Neil L. Kelleher, Julia Laskin
Publikováno v:
Angewandte Chemie International Edition. 61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b2fe34a1f4f5ae9084358afa0dde0ae
https://doi.org/10.1002/anie.202207371
https://doi.org/10.1002/anie.202207371
Autor:
Joseph B. Greer, Bryan P. Early, Kenneth R. Durbin, Steven M. Patrie, Paul M. Thomas, Neil L. Kelleher, Richard D. LeDuc, Ryan T. Fellers
Publikováno v:
Proteomics
The effectiveness of any proteomics database search depends on the theoretical candidate information contained in the protein database. Unfortunately, candidate entries from protein databases such as UniProt rarely contain all the post-translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b65136887431168ccce317a3a15698
https://europepmc.org/articles/PMC9188994/
https://europepmc.org/articles/PMC9188994/
Autor:
Neil L. Kelleher, Henrique S. Seckler, Kenneth R. Durbin, Ashley N. Ives, Ryan T. Fellers, Bryan P. Early, Taojunfeng Su, Luis F. Schachner, Steven M. Patrie, Richard D. LeDuc
Publikováno v:
J Am Soc Mass Spectrom
Protein fragmentation is a critical component of top-down proteomics, enabling gene-specific protein identification and full proteoform characterization. The factors that influence protein fragmentation include precursor charge, structure, and primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c014a8dabb8039b8fac2e15418ad912
https://doi.org/10.1021/jasms.0c00026
https://doi.org/10.1021/jasms.0c00026
Autor:
Deven L. Shinholt, Joshua T. Maze, Ryan T. Fellers, Bon Ikwuagwu, Steven C. Beu, Neil L. Kelleher, Kenneth R. Durbin, Philip D. Compton, Ping Yip, Rafael D. Melani, Danielle Tullman-Ercek, Bryan P. Early, Alexander Makarov, Michael W. Senko, Jared O. Kafader, Vlad Zabrouskov
Publikováno v:
Nature methods
A new Orbitrap-based ion analysis procedure is shown to be possible by determining the direct charge for numerous individual protein ions to generate true mass spectra. The deployment of an Orbitrap system for charge detection enables the characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c04f3eb2eefcaeb00f64bdee16e5b8
https://doi.org/10.1038/s41592-020-0764-5
https://doi.org/10.1038/s41592-020-0764-5
Autor:
Timothy K. Toby, Ryan T. Fellers, Christopher Mullen, Paul M. Thomas, Chad R. Weisbrod, Joseph B. Greer, Kenneth R. Durbin, Vlad Zabrouskov, Peter F. Doubleday, Luca Fornelli, Henrique S. Seckler, Rafael D. Melani, Kristina Srzentić, Bryan P. Early, Neil L. Kelleher, Caroline J. DeHart, Philip D. Compton, Romain Huguet
Publikováno v:
Mol Cell Proteomics
Top-down proteomics studies intact proteoform mixtures and offers important advantages over more common bottom-up proteomics technologies, as it avoids the protein inference problem. However, achieving complete molecular characterization of investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087140158ef05e278662b8ee0541cced
https://doi.org/10.1074/mcp.tir119.001638
https://doi.org/10.1074/mcp.tir119.001638
Autor:
Manxi Yang, Hang Hu, Pei Su, Paul M. Thomas, Jeannie M. Camarillo, Joseph B. Greer, Bryan P. Early, Ryan T. Fellers, Neil L. Kelleher, Julia Laskin
Unraveling the complexity of biological systems relies on the development of new approaches for spatially resolved proteoform-specific analysis of the proteome. Top-down proteomics is a powerful tool, which has been used for the identification of tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf1c48ae10e2f8ee03d5c3790e2ce5f
https://doi.org/10.26434/chemrxiv-2021-wtjm2-v2
https://doi.org/10.26434/chemrxiv-2021-wtjm2-v2
Autor:
Manxi Yang, Hang Hu, Pei Su, Paul M. Thomas, Jeannie M. Camarillo, Joseph B. Greer, Bryan P. Early, Ryan T. Fellers, Neil L. Kelleher, Julia Laskin
Publikováno v:
Angewandte Chemie (International ed. in English). 61(29)
Unraveling the complexity of biological systems relies on the development of new approaches for spatially resolved proteoform-specific analysis of the proteome. Herein, we employ nanospray desorption electrospray ionization mass spectrometry imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3dc0e720eb187ceb88b20034f52809
https://pubmed.ncbi.nlm.nih.gov/35446460
https://pubmed.ncbi.nlm.nih.gov/35446460
Autor:
Pei Su, John P. McGee, Kenneth R. Durbin, Michael A. R. Hollas, Manxi Yang, Elizabeth K. Neumann, Jamie L. Allen, Bryon S. Drown, Fatma Ayaloglu Butun, Joseph B. Greer, Bryan P. Early, Ryan T. Fellers, Jeffrey M. Spraggins, Julia Laskin, Jeannie M. Camarillo, Jared O. Kafader, Neil L. Kelleher
Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS), which increases the size limit for proteoform detection and identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84625188e5d50a57e1c1d677c03a9789
https://doi.org/10.1101/2021.12.07.471638
https://doi.org/10.1101/2021.12.07.471638
Autor:
Ryan T. Fellers, Pei Su, Paul M. Thomas, Julia Laskin, Jeannie M. Camarillo, Bryan P. Early, Manxi Yang, Neil L. Kelleher, Joseph B. Greer, Hang Hu
Unraveling the complexity of biological systems relies on the development of new approaches for spatially resolved proteoform-specific analysis of the proteome. Top-down proteomics is a powerful tool, which has been used for the identification of tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ec685945b2aec36afddb3b185b6e254
https://doi.org/10.33774/chemrxiv-2021-wtjm2
https://doi.org/10.33774/chemrxiv-2021-wtjm2