Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Bryan P Schneider"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Human induced pluripotent stem cell-derived sensory neuron (iPSC-dSN) models are a valuable resource for the study of neurotoxicity but are affected by poor replicability and reproducibility, often due to a lack of optimization. Here, we ide
Externí odkaz:
https://doaj.org/article/e31eef49ecd34743b9f694c77f9043ff
Autor:
Geneva M Cunningham, Fei Shen, Xi Wu, Erica L Cantor, Laura Gardner, Santosh Philips, Guanglong Jiang, Casey L Bales, Zhiyong Tan, Yunlong Liu, Jun Wan, Jill C Fehrenbacher, Bryan P Schneider
Publikováno v:
PLoS Genetics, Vol 18, Iss 1, p e1009968 (2022)
Taxane-induced peripheral neuropathy (TIPN) is a devastating survivorship issue for many cancer patients. In addition to its impact on quality of life, this toxicity may lead to dose reductions or treatment discontinuation, adversely impacting surviv
Externí odkaz:
https://doaj.org/article/26c22c4a3462467f86aed207b0ab7cc5
Autor:
Ahmed Bilal Khalid, Christos Fountzilas, Heather N. Burney, Hirva Mamdani, Bryan P. Schneider, Christopher Fausel, Susan M. Perkins, Shadia Jalal
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionEsophageal adenocarcinoma (EAC) remains a devastating disease and second line treatment options in the metastatic space are limited. Homologous recombination (HR) defects have been described in EAC in up to 40% of patients. Poly (ADP-ribo
Externí odkaz:
https://doaj.org/article/19fc348440154b7ba0bfc880c85865d9
Autor:
Kelly N H Nudelman, Yang Wang, Brenna C McDonald, Susan K Conroy, Dori J Smith, John D West, Darren P O'Neill, Bryan P Schneider, Andrew J Saykin
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96713 (2014)
Cerebral structural and functional alterations have been reported after chemotherapy for non-CNS cancers, yet the causative mechanism behind these changes remains unclear. This study employed a novel, non-invasive, MRI-based neuroimaging measure to p
Externí odkaz:
https://doaj.org/article/ae25152a00ba4166b4cdb9ed6779e69e
Publikováno v:
Frontiers in Genetics, Vol 3 (2013)
Two of the main research priorities in the United States are cancer and neurodegenerative diseases, which are attributed to abnormal patterns of cellular behavior. MicroRNAs (miRNA) have been implicated as regulators of cellular metabolism, and thus
Externí odkaz:
https://doaj.org/article/112a6af662b844268e75e9869608567c
Autor:
Katharine J. Head, Lisa R. Hayes, Nadia E. Miller, Safia Shakil, Casey L. Bales, Bryan P. Schneider
Publikováno v:
PEC Innovation, Vol 2, Iss , Pp 100118- (2023)
Objective: Many Black breast cancer patients experience chemotherapy-induced peripheral neuropathy (CIPN). Our study assessed Black breast cancer patients’ questions about a biomarker test that can predict likelihood of CIPN. Methods: Nineteen Blac
Externí odkaz:
https://doaj.org/article/821dd24702474f1d895ff7a5add2b615
Autor:
Xi Wu, Fei Shen, Guanglong Jiang, Gloria Xue, Santosh Philips, Laura Gardner, Geneva Cunningham, Casey Bales, Erica Cantor, Bryan Paul Schneider
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Germline variants may pre-dispose patients to an increased risk of developing anthracycline-induced cardiotoxicity. This report provides insights into the mechanism by which a common genetic variant, rs28714259, may confer an increased risk of cardia
Externí odkaz:
https://doaj.org/article/3b27b77171a943aaa7a38dd4c928b9dd
Autor:
Erica L. Cantor, Fei Shen, Guanglong Jiang, Zhiyong Tan, Geneva M. Cunningham, Xi Wu, Santosh Philips, Bryan P. Schneider
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Induced pluripotent stem cells (iPSCs) are a valuable resource for neurological disease-modeling and drug discovery due to their ability to differentiate into neurons reflecting the genetics of the patient from which they are derived. iPSC-d
Externí odkaz:
https://doaj.org/article/b6d5bbd295394a6eb0f8cd97742aac89
Autor:
Angel Qin, Fatima Lima, Samantha Bell, Gregory P. Kalemkerian, Bryan J. Schneider, Nithya Ramnath, Madelyn Lew, Santhoshi Krishnan, Shariq Mohammed, Arvind Rao, Timothy L. Frankel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Immune checkpoint inhibitors (ICI) with anti-PD-1/PD-L1 agents have improved the survival of patients with metastatic non-small cell lung cancer (mNSCLC). Tumor PD-L1 expression is an imperfect biomarker as it does not capture the complex in
Externí odkaz:
https://doaj.org/article/f435bef8f669404c8f0563c60a4c6624
Autor:
Elizabeth J. Rowe, Tyler Shugg, Reynold C. Ly, Santosh Philips, Marc B. Rosenman, John T. Callaghan, Milan Radovich, Brian R. Overholser, Bryan P. Schneider, James E. Tisdale, Todd C. Skaar
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
IntroductionDrug-induced prolongation of the heart rate-corrected QT interval (QTc) is associated with increased risk for the potentially fatal arrhythmia torsades de pointes. Due to arrhythmia risk, clinical trials with cancer therapeutics often exc
Externí odkaz:
https://doaj.org/article/3d9cbe7fcc884cde80a448883983fe03