Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Bryan P Schneider"'
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-5 (2024)
Abstract The impact of knowledge of circulating tumor DNA (ctDNA) status on patient decisions in high-risk triple-negative breast cancer (TNBC) weighing benefit and toxicity is unknown. Here, 286 women with a history of non-metastatic breast cancer w
Externí odkaz:
https://doaj.org/article/06832c8dfd4f423b81a83fc9fc0b89c8
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Human induced pluripotent stem cell-derived sensory neuron (iPSC-dSN) models are a valuable resource for the study of neurotoxicity but are affected by poor replicability and reproducibility, often due to a lack of optimization. Here, we ide
Externí odkaz:
https://doaj.org/article/e31eef49ecd34743b9f694c77f9043ff
Autor:
Ahmed Bilal Khalid, Christos Fountzilas, Heather N. Burney, Hirva Mamdani, Bryan P. Schneider, Christopher Fausel, Susan M. Perkins, Shadia Jalal
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionEsophageal adenocarcinoma (EAC) remains a devastating disease and second line treatment options in the metastatic space are limited. Homologous recombination (HR) defects have been described in EAC in up to 40% of patients. Poly (ADP-ribo
Externí odkaz:
https://doaj.org/article/19fc348440154b7ba0bfc880c85865d9
Autor:
Tara A. Seibert, Lei Shi, Sandra Althouse, Richard Hoffman, Bryan P. Schneider, Kristen A. Russ, Cody A. Altherr, Stuart J. Warden, Theresa A. Guise, Andrew R. Coggan, Tarah J. Ballinger
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract We evaluated biochemical changes in skeletal muscle of women with breast cancer initiating aromatase inhibitors (AI), including oxidation of ryanodine receptor RyR1 and loss of stabilizing protein calstabin1, and detailed measures of muscle
Externí odkaz:
https://doaj.org/article/948f97ea72cc40aebe434a8588d77a8c
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-4 (2023)
Abstract A germline pathogenic variant may be present even if the results of tumor genomic sequencing do not suggest one. There are key differences in the assay design and reporting of variants between germline and somatic laboratories. When appropri
Externí odkaz:
https://doaj.org/article/3b3aca4e6061477387ef668e34920812
Autor:
Katharine J. Head, Lisa R. Hayes, Nadia E. Miller, Safia Shakil, Casey L. Bales, Bryan P. Schneider
Publikováno v:
PEC Innovation, Vol 2, Iss , Pp 100118- (2023)
Objective: Many Black breast cancer patients experience chemotherapy-induced peripheral neuropathy (CIPN). Our study assessed Black breast cancer patients’ questions about a biomarker test that can predict likelihood of CIPN. Methods: Nineteen Blac
Externí odkaz:
https://doaj.org/article/821dd24702474f1d895ff7a5add2b615
Autor:
Xi Wu, Fei Shen, Guanglong Jiang, Gloria Xue, Santosh Philips, Laura Gardner, Geneva Cunningham, Casey Bales, Erica Cantor, Bryan Paul Schneider
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Germline variants may pre-dispose patients to an increased risk of developing anthracycline-induced cardiotoxicity. This report provides insights into the mechanism by which a common genetic variant, rs28714259, may confer an increased risk of cardia
Externí odkaz:
https://doaj.org/article/3b27b77171a943aaa7a38dd4c928b9dd
Autor:
Erica L. Cantor, Fei Shen, Guanglong Jiang, Zhiyong Tan, Geneva M. Cunningham, Xi Wu, Santosh Philips, Bryan P. Schneider
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Induced pluripotent stem cells (iPSCs) are a valuable resource for neurological disease-modeling and drug discovery due to their ability to differentiate into neurons reflecting the genetics of the patient from which they are derived. iPSC-d
Externí odkaz:
https://doaj.org/article/b6d5bbd295394a6eb0f8cd97742aac89
Autor:
Tyler Shugg, Reynold C. Ly, Wilberforce Osei, Elizabeth J. Rowe, Caitlin A. Granfield, Ty C. Lynnes, Elizabeth B. Medeiros, Jennelle C. Hodge, Amy M. Breman, Bryan P. Schneider, S. Cenk Sahinalp, Ibrahim Numanagić, Benjamin A. Salisbury, Steven M. Bray, Ryan Ratcliff, Todd C. Skaar
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundNext-generation sequencing (NGS), including whole genome sequencing (WGS) and whole exome sequencing (WES), is increasingly being used for clinic care. While NGS data have the potential to be repurposed to support clinical pharmacogenomics
Externí odkaz:
https://doaj.org/article/0e19f26f16c14c318fbd190942dc1299
Autor:
Angel Qin, Fatima Lima, Samantha Bell, Gregory P. Kalemkerian, Bryan J. Schneider, Nithya Ramnath, Madelyn Lew, Santhoshi Krishnan, Shariq Mohammed, Arvind Rao, Timothy L. Frankel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Immune checkpoint inhibitors (ICI) with anti-PD-1/PD-L1 agents have improved the survival of patients with metastatic non-small cell lung cancer (mNSCLC). Tumor PD-L1 expression is an imperfect biomarker as it does not capture the complex in
Externí odkaz:
https://doaj.org/article/f435bef8f669404c8f0563c60a4c6624