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pro vyhledávání: '"Bryan Neumann"'
A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1
Publikováno v:
MethodsX, Vol 6, Iss , Pp 2242-2247 (2019)
Acyl-CoA:cholestereol acyltransferase 1 (ACAT1) is a two-fold dimer (homotetramer) and has two distinct dimerization domains. One domain is in an alpha-helical rich region near the cytoplasmic N-terminus. The other is proposed to be near the C-termin
Externí odkaz:
https://doaj.org/article/5390642519fe4efbad6d409ad0eda2fd
A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1
Publikováno v:
MethodsX, Vol 6, Iss, Pp 2242-2247 (2019)
MethodsX
MethodsX
Graphical abstract
Acyl-CoA:cholestereol acyltransferase 1 (ACAT1) is a two-fold dimer (homotetramer) and has two distinct dimerization domains. One domain is in an alpha-helical rich region near the cytoplasmic N-terminus. The other is proposed
Acyl-CoA:cholestereol acyltransferase 1 (ACAT1) is a two-fold dimer (homotetramer) and has two distinct dimerization domains. One domain is in an alpha-helical rich region near the cytoplasmic N-terminus. The other is proposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ff56c83849fc4066b1b29ac214ea2b
http://www.sciencedirect.com/science/article/pii/S2215016119302456
http://www.sciencedirect.com/science/article/pii/S2215016119302456
Publikováno v:
Arch Biochem Biophys
To conduct biochemical studies in vitro, membrane proteins (MPs) must be solubilized with detergents. While detergents are great tools, they can also inhibit the biological activity and/or perturb oligomerization of individual MPs. Nanodisc scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::700cb454d5c56bc82a10dcf07b5f643c
https://pubmed.ncbi.nlm.nih.gov/32735863
https://pubmed.ncbi.nlm.nih.gov/32735863
Publikováno v:
Arch Biochem Biophys
Cholesterol is an important lipid molecule and is needed for all mammalian cells. In various cell types, excess cholesterol is stored as cholesteryl esters; acyl-CoA:cholesterol acyltransferase 1 (ACAT1) plays an essential role in this storage proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a2da3f4a74a78e53c41cc5c99996c7
https://pubmed.ncbi.nlm.nih.gov/31251920
https://pubmed.ncbi.nlm.nih.gov/31251920
Publikováno v:
Archives of Biochemistry and Biophysics. 691:108518
To conduct biochemical studies in vitro, membrane proteins (MPs) must be solubilized with detergents. While detergents are great tools, they can also inhibit the biological activity and/or perturb oligomerization of individual MPs. Nanodisc scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a469d4a3b826ac78d24119466f75da9
https://doi.org/10.1016/j.abb.2020.108518
https://doi.org/10.1016/j.abb.2020.108518