Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Bryan N Kahner"'
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34056 (2012)
Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effective activation of integrin αIIbβ3 and resulting high-affinity ligand binding in platelets. However, binding of the talin head domain alone to β3 is suffi
Externí odkaz:
https://doaj.org/article/e227b59e94a841b6bca6a72d96147a61
Publikováno v:
Platelets. 17:397-404
Previous studies have proposed that stimulation of G protein-coupled receptors can cause a redistribution of G proteins to other receptors. The redistribution would cause a greater functional sensitivity of unsensitized 'secondary' receptors toward t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192fcd36a86a1045f377336209114ca6
https://doi.org/10.1080/09537100600757794
https://doi.org/10.1080/09537100600757794
Autor:
Sanford J. Shattil, Mark H. Ginsberg, Feng Ye, Bryan N. Kahner, Jian Kang, Ana Kasirer-Friede
Publikováno v:
Blood. 123(20)
ADAP is a hematopoietic-restricted adapter protein that promotes integrin activation and is a carrier for other adapter proteins, Src kinase–associated phosphoprotein 1 (SKAP1) and SKAP2. In T lymphocytes, SKAP1 is the ADAP-associated molecule that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6756db64fb5f23a4fa293f3447d405c9
https://pubmed.ncbi.nlm.nih.gov/24832940
https://pubmed.ncbi.nlm.nih.gov/24832940
Autor:
Satya P. Kunapuli, Robert T. Dorsam, Timothy J. Stalker, Sripal R. Mada, Soochong Kim, James L. Daniel, Bryan N. Kahner, Lawrence F. Brass, Daisuke Kitamura
Collagen activates platelets through an intracellular signaling cascade downstream of glycoprotein VI (GPVI). We have investigated the contribution of hematopoietic lineage cell–specific protein 1 (HS1) downstream of GPVI in platelet activation. St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9529197bdbfa16ec9200c6055334dadc
https://europepmc.org/articles/PMC1988959/
https://europepmc.org/articles/PMC1988959/
Publikováno v:
Current drug targets. 7(10)
Platelet activation and aggregation is an integral component of the pathophysiology that leads to thrombotic and ischemic diseases such as cerebral stroke, peripheral vascular disease and myocardial infarction. Anti-platelet agents (such as aspirin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fcace881ca1c32ccb0b87abd14ce5d
https://pubmed.ncbi.nlm.nih.gov/17073586
https://pubmed.ncbi.nlm.nih.gov/17073586
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 4(11)
Upon injury to a vessel wall the exposure of subendothelial collagen results in the activation of platelets. Platelet activation culminates in shape change, aggregation, release of granule contents and generation of lipid mediators. These secreted an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a88bc5cc71dbadf4e961644b9713e55
https://pubmed.ncbi.nlm.nih.gov/17059469
https://pubmed.ncbi.nlm.nih.gov/17059469
Autor:
Satya P. Kunapuli, Soochong Kim, Parth Lakhani, Janani Prabhakar, Bryan N. Kahner, Haripriya Shankar
Publikováno v:
Blood. 108(9)
ADP-induced TXA2 generation requires the costimulation of P2Y1, P2Y12, and the GPIIb/IIIa receptors. Signaling events downstream of the P2Y receptors that contribute to ADP-induced TXA2 generation have not been clearly delineated. In this study, we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9c3d10be8894e7a27504d0538ab0f3
https://pubmed.ncbi.nlm.nih.gov/16857990
https://pubmed.ncbi.nlm.nih.gov/16857990
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34056 (2012)
PLoS ONE
PLoS ONE
Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effective activation of integrin αIIbβ3 and resulting high-affinity ligand binding in platelets. However, binding of the talin head domain alone to β3 is suffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299160c8caf7150c0483cd7e276a5fe5
https://doi.org/10.1371/journal.pone.0034056
https://doi.org/10.1371/journal.pone.0034056
Publikováno v:
Blood. 118:188-188
Abstract 188 Platelets respond to excitatory agonists by binding adhesive ligands, such as fibrinogen, and by aggregating during hemostasis and thrombosis. These processes require the activation of αIIbβ3 from a low- to a high-affinity state. Activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f5441f4d52305886b76da6c7f308f93
https://doi.org/10.1182/blood.v118.21.188.188
https://doi.org/10.1182/blood.v118.21.188.188
Publikováno v:
Frontiers in Bioscience. 13:433
Microparticles are shed from the platelet membrane upon platelet activation by strong agonists, and they aid in clot formation. As the P2Y1 and the P2Y12 receptors differentially contribute to different platelet functions, we studied the relative con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5069aa0c8e43e313349deecf1052d815
https://doi.org/10.2741/2690
https://doi.org/10.2741/2690