Výsledky vyhledávání - "Bryan McCune"

Development of a LAG-3 Immunohistochemistry Assay for Melanoma

Autor: Lori Johnson, Bryan McCune, Darren Locke, Cyrus Hedvat, John B Wojcik, Caitlin Schroyer, Jim Yan, Krystal Johnson, Angela Sanders-Cliette, Sujana Samala, Lloye M Dillon, Steven Anderson, Jeffrey Shuster

AimsA robust immunohistochemistry (IHC) assay was developed to detect lymphocyte-activation gene 3 (LAG-3) expression by immune cells (ICs) in tumor tissues. LAG-3 is an immuno-oncology target with demonstrable clinical benefit, and there is a need f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44433ff664252fc81d6b391199a041a
https://doi.org/10.1101/2022.02.25.481964

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Abstract 1625: Distribution and prevalence of LAG-3 expression in samples of melanoma and gastric/gastroesophageal junction cancer

Autor: Bin Li, Keyur Desai, Krystal Johnson, Bryan McCune, Jeffrey Shuster, Ming Lei, Steven M. Anderson, Lloye M. Dillon, John Wojcik, Lori Johnson

Publikováno v: Cancer Research. 81:1625-1625

Background: Immune checkpoint inhibitors (ICIs) have become the standard of care in a range of tumors. However, a large proportion of patients treated with ICIs have treatment-refractory/resistant tumors requiring innovative approaches. Lymphocyte-ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe9945fb38df4f5ab27c15bb4cf41efe
https://doi.org/10.1158/1538-7445.am2021-1625

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Determination of HER2 Gene Amplification by Fluorescence In situ Hybridization and Concordance with the Clinical Trials Immunohistochemical Assay in Women with Metastatic Breast Cancer Evaluated for Treatment with Trastuzumab

Autor: Grazyna Leiberman, Robert L. Cohen, Bryan McCune, Noel Dybdal, Alex Bajamonde, Robert D. Mass, Steven M. Anderson, Corsee Sanders, Michael F. Press

Publikováno v: Breast Cancer Research and Treatment. 93:3-11

Purpose. To evaluate the concordance between HER2 gene amplification, determined by fluorescence in situ hybridization (FISH), and HER2 protein overexpression assessed by an immunohistochemical (IHC) assay. The IHC protocol used was a research assay,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6002acaaf187b2d5afbf1d285c35615e
https://doi.org/10.1007/s10549-004-6275-8

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Abstract 663: Clinical performance and utilization of 3 PD-L1 immunohistochemical assays

Autor: Bryan McCune, Ronald Paler, Steven Anderson, Bruce Horten

Publikováno v: Cancer Research. 77:663-663

Three different PD-L1 immunohistochemical (IHC) assays have recently been approved to help guide treatment decisions regarding anti-PD-1 (Keytruda®, Opdivo®) and anti-PD-L1 (Tecentriq®) immuno-oncology based therapies. The three assays differ in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c523ef150315316ea6c4756958a7804
https://doi.org/10.1158/1538-7445.am2017-663

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Companion and complementary diagnostics for PD-L1 expression assessment in non-small cell lung cancer

Autor: Bryan McCune, Bruce Horten, Ronald Paler, Steven M. Anderson

Publikováno v: Journal of Clinical Oncology. 34:11612-11612

11612Background: Recently two different immunohistochemical assays for PD-L1 expression in non-small cell lung cancers have been approved in conjunction with immune checkpoint inhibitors. One assay...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8129bbbc16cbbc67a9d536f5abb39788
https://doi.org/10.1200/jco.2016.34.15_suppl.11612

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Abstract 1549: Development and validation of a biomarker for prospective selection of Notch1 activation in patients with certain advanced solid tumors in a first-in-human phase1 study of the cancer stem cell targeting antibody OMP-52M51 (anti-Notch1)

Autor: Esohe Idusogie, Bryan McCune, Lori Johnson, Ann M. Kapoun, Raymond Tam, John Lewicki, Tim Hoey, Steve Anderson, Chun Zhang, Belinda Cancilla

Publikováno v: Cancer Research. 75:1549-1549

Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA The Notch pathway plays a key role in embryonic development, the regulation of stem and progenitor cells, and is implicated centrally in many forms of human cancer. Notc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74c64453675f0517deedf1ae05bacab4
https://doi.org/10.1158/1538-7445.am2015-1549

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Application of flow cytometry to studies on the distribution, persistence, and regeneration rate of Epstein-Barr virus receptors

Autor: Bryan McCune, David J. Volsky

Publikováno v: Cytometry. 5:523-529

Flow cytometry has been applied to study the persistence and regeneration rate of Epstein-Barr virus (EBV) receptors and other membrane proteins in normal and tumor cells. EBV receptors were detected in a binding assay utilizing fluorescein isothiocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b0a92280555065e126975f3f433757
https://doi.org/10.1002/cyto.990050514

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