Výsledky vyhledávání - "Bryan Mackenzie"

Akademický článek

M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling

Autor: John G. Noel, Seth W. Ramser, Lori Pitstick, John P. Bonamer, Bryan Mackenzie, Katie G. Seu, Theodosia A. Kalfa, Jose A. Cancelas, Jason C. Gardner

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract M-CSF receptor signaling supports the development and survival of mononuclear phagocytes and is thought to play a role in post burn anemia by promoting myeloid lineage bias. We found M-CSF secretion was increased in burn patients and a murin

Externí odkaz: https://doaj.org/article/574ad174994b4b668e96e765e451a0b2

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Calcium is an essential cofactor for metal efflux by the ferroportin transporter family

Autor: Chandrika N. Deshpande, T. Alex Ruwe, Ali Shawki, Vicky Xin, Kyle R. Vieth, Erika V. Valore, Bo Qiao, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Ferroportin (Fpn) is essential for mammalian iron homeostasis as it exports iron from cells into blood circulation, but the molecular mechanisms of Fpn-mediated iron transport remain obscure. Here the authors use biophysical approaches to reveal that

Externí odkaz: https://doaj.org/article/61dff6b0396e40ccba89522883e761ae

Zobrazit plný text záznamu

Comparative analysis of the functional properties of human and mouse ferroportin

Autor: Corbin R. Azucenas, T. Alex Ruwe, John P. Bonamer, Bo Qiao, Tomas Ganz, Mika Jormakka, Elizabeta Nemeth, Bryan Mackenzie

Publikováno v: American Journal of Physiology-Cell Physiology. 324:C1110-C1118

Ferroportin (Fpn)—expressed at the plasma membrane of macrophages, enterocytes, and hepatocytes—mediates the transfer of cellular iron into the blood plasma. Under the control of the iron-regulatory hormone hepcidin, Fpn serves a critical role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f66a3bd484de08f90c1f2ce2e95657fc
https://doi.org/10.1152/ajpcell.00063.2023

Zobrazit plný text záznamu

Isolation and thermal stabilization of mouse ferroportin

Autor: Bo Qiao, So Iwata, Chandrika N. Deshpande, Mika Jormakka, Norimichi Nomura, Elizabeta Nemeth, Josep Font, Bryan Mackenzie, Corbin R. Azucenas, Tomas Ganz, Vicky Xin

Publikováno v: FEBS Open Bio

Here, Deshpande et al. describe the production and purification of mouse ferroportin (Fpn), the only known mammalian iron efflux protein, and selective loop deletion constructs with enhanced thermal stability. Transport activity and hepcidin responsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2120c07ef4b9f757eeed046c54cfe4
https://doi.org/10.1002/2211-5463.13039

Zobrazit plný text záznamu

Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin

Autor: Bo Qiao, Mika Jormakka, T Alex Ruwe, Sharraya Aschemeyer, Kyle R. Vieth, Tomas Ganz, Bryan Mackenzie, Deborah Stefanova, Albert C. Sek, Stefano Rivella, Erika V. Valore, Carla Casu, Elizabeta Nemeth, Grace Jung

Publikováno v: Blood. 131:899-910

Nonclassical ferroportin disease (FD) is a form of hereditary hemochromatosis caused by mutations in the iron transporter ferroportin (Fpn), resulting in parenchymal iron overload. Fpn is regulated by the hormone hepcidin, which induces Fpn endocytos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe457e05e36c922303764756b0ef709
https://doi.org/10.1182/blood-2017-05-786590

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání