Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Bryan M. Rafferty"'
Autor:
Wensheng Lang, William J. Jones, Gary W. Caldwell, William Hageman, Jeffrey Hall, John A. Masucci, Bryan M. Rafferty
Publikováno v:
Analytical Biochemistry. 333:79-87
A simple and selective assay for the evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors was developed through the simultaneous determination of endogenous 5-hydroxy tryptamine, 5-h
Autor:
Tamara A. Miskowski, Raymond W. Colburn, Jian Li, Jeffrey M. Palmer, Wei He, Dennis J. Stone, N. H. Wallace, Rebecca P. Martinez, Craig R. Schneider, Sui-Po Zhang, Henry J. Breslin, Bryan M. Rafferty, Edward S. Kimball, Santosh V. Coutinho
Publikováno v:
Journal of medicinal chemistry. 47(21)
A small series of novel, imidazoles 4 have been prepared that exhibit very good binding affinities for the delta and mu opioid receptors (ORs), as well as demonstrate potent agonist functional activity at the delta OR. Representative imidazole 4a (K(
Autor:
William J. Jones, Zhengyin Yan, Gary W. Caldwell, Bryan M. Rafferty, L. A. McKown, John A. Masucci, Wu-Nan Wu
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 32(11)
1. In vitro studies have been carried out to investigate the metabolic pathways and identify the hepatic cytochrome P450 (CYP) enzymes involved in etoperidone (Et) metabolism. 2. Ten in vitro metabolites were profiled, quantified and tentatively iden