Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bryan Knipe"'
Publikováno v:
Free Radical Biology and Medicine. 51:1601-1609
Oxidative damage of the endothelium disrupts the integrity of the blood-brain barrier (BBB). We have shown before that alcohol exposure increases the levels of reactive oxygen species (ROS; superoxide and hydroxyl radical) and nitric oxide (NO) in br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb9ced797f8dab8efa76b78c2d03d51
https://doi.org/10.1016/j.freeradbiomed.2011.06.020
https://doi.org/10.1016/j.freeradbiomed.2011.06.020
Autor:
Kathy Schall, Bryan Knipe, Anil Papugani, Raghava Potula, Servio H. Ramirez, David Heilman, Aaron J. Mercer, Huanyu Dou, Yuri Persidsky, Brenda Morsey, Jessica Leibhart
Publikováno v:
AIDS. 22:1539-1549
Objective Poor penetration of anti-retroviral therapy across the blood brain barrier (BBB) poses an impediment on control of HIV-1 infection in brain macrophages. PPARγ, a member of the nuclear receptors family, regulates important physiological fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::289bb1fb13addb1e6db0223c34a65747
https://doi.org/10.1097/qad.0b013e3283081e08
https://doi.org/10.1097/qad.0b013e3283081e08
Publikováno v:
Journal of Neurochemistry. 100:324-336
The blood-brain barrier (BBB) formed by brain microvascular endothelial cells (BMVEC), pericytes and astrocytes controls the transport of ions, peptides and leukocytes in and out of the brain. Tight junctions (TJ) composed of TJ proteins (occludin, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0a05b4652f0fc46bace67d6e8e9916
https://doi.org/10.1111/j.1471-4159.2006.04245.x
https://doi.org/10.1111/j.1471-4159.2006.04245.x
Autor:
Jessica Leibhart, James Haorah, David Heilman, Donald W. Miller, Yuri Persidsky, Bryan Knipe, Jesse Chrastil, Anuja Ghorpade
Publikováno v:
Alcoholism: Clinical & Experimental Research. 29:999-1009
Background: Brain endothelial cells form the blood-brain barrier (BBB) that regulates solute and macromolecule flux in and out of the brain, leukocyte migration, and maintains the homeostasis of the central nervous system. BBB dysfunction is associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd856aa95baf3f07fbd255ec8a6a8e1
https://doi.org/10.1097/01.alc.0000166944.79914.0a
https://doi.org/10.1097/01.alc.0000166944.79914.0a
Autor:
Georgette D. Kanmogne, Jessica Leibhart, Kathy Schall, Yuri Persidsky, Bryan Knipe, Howard E. Gendelman
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 27(1)
Human immunodeficiency virus-1 (HIV-1) encephalitis is characterized by brain infiltration of virus-infected monocytes and macrophages. Cellular products and viral proteins secreted by infected cells likely play an important role in blood–brain bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd4aec46b398cfb0f9aca308c2760ec
https://pubmed.ncbi.nlm.nih.gov/16685256
https://pubmed.ncbi.nlm.nih.gov/16685256
Autor:
James Haorah, Anuja Ghorpade, Rindha Reddy, Bryan Knipe, Huanyu Dou, Yuri Persidsky, Jessica Leibhart, Jesse Chrastil, Raghava Potula, David Heilman
Publikováno v:
The American journal of pathology. 168(4)
Neuroinflammatory disorders (including human immunodeficiency virus-1 encephalitis, HIVE) are associated with oxidative stress and inflammatory brain injury, and excessive alcohol use can exacerbate tissue damage. Using a murine model of HIVE, we inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a59c9aaf88d439d63fd6ac8db560102
https://pubmed.ncbi.nlm.nih.gov/16565506
https://pubmed.ncbi.nlm.nih.gov/16565506
Publikováno v:
Journal of leukocyte biology. 78(6)
Brain microvascular endothelial cells (BMVEC) connected by tight junctions (TJ) form a tight monolayer at the blood-brain barrier (BBB). We investigated the idea that BBB dysfunction seen in alcohol abuse is associated with oxidative stress stemming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ee40165863eeec19edaec84ef90ab3
https://pubmed.ncbi.nlm.nih.gov/16204625
https://pubmed.ncbi.nlm.nih.gov/16204625