Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Bryan J Traynor"'
Autor:
Richard F Oppong, Antonio Terracciano, Martin Picard, Yong Qian, Thomas J Butler, Toshiko Tanaka, Ann Zenobia Moore, Eleanor M Simonsick, Krista Opsahl-Ong, Christopher Coletta, Angelina R Sutin, Myriam Gorospe, Susan M Resnick, Francesco Cucca, Sonja W Scholz, Bryan J Traynor, David Schlessinger, Luigi Ferrucci, Jun Ding
Publikováno v:
eLife, Vol 11 (2022)
Background: Mitochondrial DNA copy number (mtDNAcn) in tissues and blood can be altered in conditions like diabetes and major depression and may play a role in aging and longevity. However, little is known about the association between mtDNAcn and pe
Externí odkaz:
https://doaj.org/article/64ebb18f36834dd8a52e9975164dd757
Autor:
Joel Oger, Joshua D Green, Bryan J Traynor, Richard J Barohn, Michael Benatar, Emanuela Bartoccion, Derrick Blackmore, Manisha Chopra, Andrea Corse, Mazen M Dimachkie, Amelia Evoli, Julaine Florence, Miriam Freimer, James F Howard, Theresa Jiwa, Henry J Kaminski, John T Kissel, Wilma J Koopman, Bernadette Lipscomb, Michelanglo Maestri, Mariapaola Marino, Janice M Massey, April McVey, Michelle M Mezei, Michael W Nicolle, Robert M Pascuzzi, Mamatha Pasnoor, Alan Pestronk, Carlo Provenzano, Roberta Ricciardi, David P Richman, Julie Rowin, Donald B Sanders, Zaeem Siddiqi, Aimee Soloway, Gil I Wolfe, Charlie Wulf, Daniel B Drachman
Publikováno v:
BMJ Open, Vol 10, Iss 9 (2020)
Objectives To approximate the rate of familial myasthenia gravis and the coexistence of other autoimmune disorders in the patients and their families.Design Retrospective cohort study.Setting Clinics across North America.Participants The study includ
Externí odkaz:
https://doaj.org/article/0145aad817a242af8725bc4e583792df
Autor:
Ece Bayram, Paolo Reho, Irene Litvan, International LBD Genomics Consortium, Jinhui Ding, J. Raphael Gibbs, Clifton L. Dalgard, Bryan J. Traynor, Sonja W. Scholz, Ruth Chia
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Sex influences the prevalence and symptoms of Lewy body dementia (LBD). However, genome-wide association studies typically focus on autosomal variants and exclude sex-specific risk factors. We addressed this gap by performing an X chromosome
Externí odkaz:
https://doaj.org/article/4b0bdd16236c46ffb7fc3ff2e86da758
Autor:
Yue Zhao, Xiayan Li, Kai Wang, Gayatri Iyer, Stacey A. Sakowski, Lili Zhao, Samuel Teener, Kelly M. Bakulski, John F. Dou, Bryan J. Traynor, Alla Karnovsky, Stuart A. Batterman, Eva L. Feldman, Maureen A. Sartor, Stephen A. Goutman
Publikováno v:
EBioMedicine, Vol 109, Iss , Pp 105383- (2024)
Summary: Background: Amyotrophic lateral sclerosis (ALS) is linked to ageing and genetic and environmental risk factors, yet underlying mechanisms are incompletely understood. We aimed to evaluate epigenetic age acceleration (EAA), i.e., DNA methylat
Externí odkaz:
https://doaj.org/article/92ff37f3959d477f9169be8c420e4624
Autor:
Paolo Reho, Sara Saez-Atienzar, Paola Ruffo, Sultana Solaiman, Zalak Shah, Ruth Chia, Karri Kaivola, Bryan J. Traynor, Bension S. Tilley, Steve M. Gentleman, Angela K. Hodges, Dag Aarsland, Edwin S. Monuki, Kathy L. Newell, Randy Woltjer, Marilyn S. Albert, Ted M. Dawson, Liana S. Rosenthal, Juan C. Troncoso, Olga Pletnikova, Geidy E. Serrano, Thomas G. Beach, Hariharan P. Easwaran, Sonja W. Scholz
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population. We performed genome-wide DNA methylation mapping of cerebellar tissue from pathologically confirmed DLB cases and controls to study the epigenetic profil
Externí odkaz:
https://doaj.org/article/1f5a47a3a95d4835830f83e30874d417
Autor:
Jen-Chyong Wang, Noah Spiegel, Sarah Bertelsen, Nhung Le, Nicholas McKenna, John P Budde, Oscar Harari, Manav Kapoor, Andrew Brooks, Dana Hancock, Jay Tischfield, Tatiana Foroud, Laura J Bierut, Joe Henry Steinbach, Howard J Edenberg, Bryan J Traynor, Alison M Goate
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80204 (2013)
Variants within the gene cluster encoding α3, α5, and β4 nicotinic receptor subunits are major risk factors for substance dependence. The strongest impact on risk is associated with variation in the CHRNA5 gene, where at least two mechanisms are a
Externí odkaz:
https://doaj.org/article/6315638ad53c4aa2a1563c7a76729799
Autor:
J Raphael Gibbs, Marcel P van der Brug, Dena G Hernandez, Bryan J Traynor, Michael A Nalls, Shiao-Lin Lai, Sampath Arepalli, Allissa Dillman, Ian P Rafferty, Juan Troncoso, Robert Johnson, H Ronald Zielke, Luigi Ferrucci, Dan L Longo, Mark R Cookson, Andrew B Singleton
Publikováno v:
PLoS Genetics, Vol 6, Iss 5, p e1000952 (2010)
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We present a set of integrated experiments that investigate the effects of common ge
Externí odkaz:
https://doaj.org/article/2c6bddb840f5434bb40322ece5b8e839
Autor:
Rita J Guerreiro, Jennifer C Schymick, Cynthia Crews, Andrew Singleton, John Hardy, Bryan J Traynor
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2450 (2008)
BackgroundTAR DNA binding protein, encoded by TARDBP, was shown to be a central component of ubiquitin-positive, tau-negative inclusions in frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Recently, mutations in TAR
Externí odkaz:
https://doaj.org/article/27099a73191a4f369aeb28c169b83464
Autor:
Katrina Gwinn, Roderick A Corriveau, Hiroshi Mitsumoto, Kate Bednarz, Robert H Brown, Merit Cudkowicz, Paul H Gordon, John Hardy, Edward J Kasarskis, Petra Kaufmann, Robert Miller, Eric Sorenson, Rup Tandan, Bryan J Traynor, Josefina Nash, Alex Sherman, Matthew D Mailman, James Ostell, Lucie Bruijn, Valerie Cwik, Stephen S Rich, Andrew Singleton, Larry Refolo, Jaime Andrews, Ran Zhang, Robin Conwit, Margaret A Keller, ALS Research Group
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1254 (2007)
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND). It is currently incurable and treatment is largely limited to supportive care. Family history is associated with an increased risk of ALS, and many Mendelian c
Externí odkaz:
https://doaj.org/article/810eaf8daa3c4dc8ab0673f7e64b23f9
Autor:
Rita Sattler, Bryan J. Traynor, Janice Robertson, Ludo Van Den Bosch, Sami J. Barmada, Clive N. Svendsen, Matthew D. Disney, Tania F. Gendron, Philip C. Wong, Martin R. Turner, Adam Boxer, Suma Babu, Michael Benatar, Michael Kurnellas, Jonathan D. Rohrer, Christopher J. Donnelly, Lynette M. Bustos, Kendall Van Keuren-Jensen, Penny A. Dacks, Marwan N. Sabbagh, Attendees of the inaugural C9ORF72 FTD/ALS Summit
Publikováno v:
Neurology and Therapy, Vol 12, Iss 6, Pp 1821-1843 (2023)
Abstract A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS; C9ORF72-FTD/ALS). The goal
Externí odkaz:
https://doaj.org/article/29cedee3ed35403a952639263a5b1ede