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pro vyhledávání: '"Bryan Hayden Landis"'
Publikováno v:
Organic Process Research & Development. 6:547-552
Gluconobacter oxydans has the unique ability to regioselectively and rapidly oxidize sorbitol and other erythro saccharides. In this report a new process is described by which N-butylglucamine is regioselectively oxidized by the organism. A large-sca
Publikováno v:
Organic Process Research & Development. 6:539-546
Penicillin amidohydrolase [EC 3.5.1.11] was used to resolve stereoisomers of a β-amino acid ester (ethyl 3-amino-5-(tri-methylsilyl)-4-pentynoate) by phenylacetylation. After screening commercially available sources of the immobilized enzyme, one wa
Publikováno v:
Bioorganicmedicinal chemistry. 7(10)
The beta-amino acid, (S)-ethyl-3-amino-4-pentynoate, is a chiral synthon used in the synthesis of xemilofiban hydrochloride, an anti-platelet agent. A biocatalytic approach was developed to resolve (R)- and (S)-enantiomers of ethyl 3-amino-4-pentynoa